Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response

Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response

Summary: Dysregulated amino acid increases the risk for heart failure (HF) via unclear mechanisms. Here, we find that increased plasma tyrosine and phenylalanine levels are associated with HF. Increasing tyrosine or phenylalanine by high-tyrosine or high-phenylalanine chow feeding exacerbates HF phe...

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Bibliographic Details
Main Authors: Rui Zhao, Ke Cai, Jing-Jing Yang, Qian Zhou, Wei Cao, Jie Xiang, Yi-Hui Shen, Lei-Lei Cheng, Wei-Dong Zang, Yan Lin, Yi-Yuan Yuan, Wei Xu, Hui Tao, Shi-Min Zhao, Jian-Yuan Zhao
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723004114

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