Impaired causal awareness and associated cortical–basal ganglia structural changes in youth psychiatric disorders
Background: Cognitive impairments contribute significantly to disease burden in young individuals presenting with major psychiatric disorders. The capacity to encode the consequences of one's actions may be of particular importance for real-world functioning due to its fundamental role in goal-...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158216301152 |
| _version_ | 1818694697483239424 |
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| author | Kristi R. Griffiths Jim Lagopoulos Daniel F. Hermens Rico S.C. Lee Adam J. Guastella Ian B. Hickie Bernard W. Balleine |
| author_facet | Kristi R. Griffiths Jim Lagopoulos Daniel F. Hermens Rico S.C. Lee Adam J. Guastella Ian B. Hickie Bernard W. Balleine |
| author_sort | Kristi R. Griffiths |
| collection | DOAJ |
| description | Background: Cognitive impairments contribute significantly to disease burden in young individuals presenting with major psychiatric disorders. The capacity to encode the consequences of one's actions may be of particular importance for real-world functioning due to its fundamental role in goal-directed behavior.
Methods: Here, we investigated a dimensional measure of causal awareness during a probabilistic learning task in 92 young individuals with an admixture of major mood and psychotic illnesses, at early and more established stages. Using automated gray matter segmentation of T1-weighted images, we estimated the volume and shapes of major subcortical structures and investigated their association with causal awareness.
Results: The low causal awareness (LCA) group (n = 35) reported increased social disability (p = .004) and reduced right pallidal size, specifically within the dorsolateral surfaces (p = .02), relative to the unimpaired high causal awareness (HCA) patients (n = 57). In early-stage illness, LCA had a smaller right thalamus (p = .002) relative to HCA. Exploratory investigations suggested that in developed psychotic syndromes, causal awareness was correlated with left hippocampal size (p = .006) whereas, in more persistent affective disorders, causal awareness was correlated with left amygdala size (p = .013), specifically within the anterior aspect.
Discussion: Low causal awareness occurs across diagnoses and stages of illness and is associated with poor functional outcomes. Our results suggest that there may be shared neural underpinnings of its dysfunction in the early course of mood and psychotic disorders, however in more established illness, there is greater neurobiological divergence in causal awareness correlates between diagnoses. |
| first_indexed | 2024-12-17T13:33:42Z |
| format | Article |
| id | doaj.art-43bd3a5bd48840f4a83a384beae0d5dc |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-17T13:33:42Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-43bd3a5bd48840f4a83a384beae0d5dc2022-12-21T21:46:30ZengElsevierNeuroImage: Clinical2213-15822016-01-0112C28529210.1016/j.nicl.2016.06.017Impaired causal awareness and associated cortical–basal ganglia structural changes in youth psychiatric disordersKristi R. Griffiths0Jim Lagopoulos1Daniel F. Hermens2Rico S.C. Lee3Adam J. Guastella4Ian B. Hickie5Bernard W. Balleine6Brain and Mind Centre, University of Sydney, AustraliaBrain and Mind Centre, University of Sydney, AustraliaBrain and Mind Centre, University of Sydney, AustraliaBrain and Mind Centre, University of Sydney, AustraliaBrain and Mind Centre, University of Sydney, AustraliaBrain and Mind Centre, University of Sydney, AustraliaSchool of Psychology, University of NSW, AustraliaBackground: Cognitive impairments contribute significantly to disease burden in young individuals presenting with major psychiatric disorders. The capacity to encode the consequences of one's actions may be of particular importance for real-world functioning due to its fundamental role in goal-directed behavior. Methods: Here, we investigated a dimensional measure of causal awareness during a probabilistic learning task in 92 young individuals with an admixture of major mood and psychotic illnesses, at early and more established stages. Using automated gray matter segmentation of T1-weighted images, we estimated the volume and shapes of major subcortical structures and investigated their association with causal awareness. Results: The low causal awareness (LCA) group (n = 35) reported increased social disability (p = .004) and reduced right pallidal size, specifically within the dorsolateral surfaces (p = .02), relative to the unimpaired high causal awareness (HCA) patients (n = 57). In early-stage illness, LCA had a smaller right thalamus (p = .002) relative to HCA. Exploratory investigations suggested that in developed psychotic syndromes, causal awareness was correlated with left hippocampal size (p = .006) whereas, in more persistent affective disorders, causal awareness was correlated with left amygdala size (p = .013), specifically within the anterior aspect. Discussion: Low causal awareness occurs across diagnoses and stages of illness and is associated with poor functional outcomes. Our results suggest that there may be shared neural underpinnings of its dysfunction in the early course of mood and psychotic disorders, however in more established illness, there is greater neurobiological divergence in causal awareness correlates between diagnoses.http://www.sciencedirect.com/science/article/pii/S2213158216301152Instrumental learningCausal awarenessVolumetricsShape analysisPallidumYouth |
| spellingShingle | Kristi R. Griffiths Jim Lagopoulos Daniel F. Hermens Rico S.C. Lee Adam J. Guastella Ian B. Hickie Bernard W. Balleine Impaired causal awareness and associated cortical–basal ganglia structural changes in youth psychiatric disorders NeuroImage: Clinical Instrumental learning Causal awareness Volumetrics Shape analysis Pallidum Youth |
| title | Impaired causal awareness and associated cortical–basal ganglia structural changes in youth psychiatric disorders |
| title_full | Impaired causal awareness and associated cortical–basal ganglia structural changes in youth psychiatric disorders |
| title_fullStr | Impaired causal awareness and associated cortical–basal ganglia structural changes in youth psychiatric disorders |
| title_full_unstemmed | Impaired causal awareness and associated cortical–basal ganglia structural changes in youth psychiatric disorders |
| title_short | Impaired causal awareness and associated cortical–basal ganglia structural changes in youth psychiatric disorders |
| title_sort | impaired causal awareness and associated cortical basal ganglia structural changes in youth psychiatric disorders |
| topic | Instrumental learning Causal awareness Volumetrics Shape analysis Pallidum Youth |
| url | http://www.sciencedirect.com/science/article/pii/S2213158216301152 |
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