LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients

LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients

Abstract Background Tumor recurrence, the chief reason for poor prognosis of glioma, is largely attributed to glioma stem cells (GSCs) and epithelial-mesenchymal transition (EMT). However, the mechanisms among them remain unknown. Here, we determined whether leucine-rich repeat-containing G protein-...

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Bibliographic Details
Main Authors: Jin Zhang, Hongqing Cai, Lixin Sun, Panpan Zhan, Meng Chen, Feng Zhang, Yuliang Ran, Jinghai Wan
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glioma stem cell
LGR5
EMT
Wnt/β-catenin
Glioma recurrence
Glioma survival
Online Access:http://link.springer.com/article/10.1186/s13046-018-0864-6

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