Serum Calcium and the Risk of Incident Metabolic Syndrome: A 4.3-Year Retrospective Longitudinal Study
BackgroundAn association between serum calcium level and risk of metabolic syndrome (MetS) has been suggested in cross-sectional studies. This study aimed to evaluate the association between baseline serum calcium level and risk of incident MetS in a longitudinal study.MethodsWe conducted a retrospe...
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| Language: | English |
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Korean Diabetes Association
2017-01-01
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| Series: | Diabetes & Metabolism Journal |
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| Online Access: | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-41-60.pdf |
| _version_ | 1828972417528102912 |
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| author | Jong Ha Baek Sang-Man Jin Ji Cheol Bae Jae Hwan Jee Tae Yang Yu Soo Kyoung Kim Kyu Yeon Hur Moon-Kyu Lee Jae Hyeon Kim |
| author_facet | Jong Ha Baek Sang-Man Jin Ji Cheol Bae Jae Hwan Jee Tae Yang Yu Soo Kyoung Kim Kyu Yeon Hur Moon-Kyu Lee Jae Hyeon Kim |
| author_sort | Jong Ha Baek |
| collection | DOAJ |
| description | BackgroundAn association between serum calcium level and risk of metabolic syndrome (MetS) has been suggested in cross-sectional studies. This study aimed to evaluate the association between baseline serum calcium level and risk of incident MetS in a longitudinal study.MethodsWe conducted a retrospective longitudinal study of 12,706 participants without MetS who participated in a health screening program, had normal range serum calcium level at baseline (mean age, 51 years), and were followed up for 4.3 years (18,925 person-years). The risk of developing MetS was analyzed according to the baseline serum calcium levels.ResultsA total of 3,448 incident cases (27.1%) of MetS developed during the follow-up period. The hazard ratio (HR) for incident MetS did not increase with increasing tertile of serum calcium level in an age- and sex-matched model (P for trend=0.915). The HRs (95% confidence interval [CI]) for incident MetS comparing the second and the third tertiles to the first tertile of baseline serum calcium level were 0.91 (95% CI, 0.84 to 0.99) and 0.85 (95% CI, 0.78 to 0.92) in a fully adjusted model, respectively (P for trend=0.001). A decreased risk of incident MetS in higher tertiles of serum calcium level was observed in subjects with central obesity and/or a metabolically unhealthy state at baseline.ConclusionThere was no positive correlation between baseline serum calcium levels and incident risk of MetS in this longitudinal study. There was an association between higher serum calcium levels and decreased incident MetS in individuals with central obesity or two components of MetS at baseline. |
| first_indexed | 2024-12-14T13:28:45Z |
| format | Article |
| id | doaj.art-43bd68a97c2c42589dfb536062de4375 |
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| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-14T13:28:45Z |
| publishDate | 2017-01-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-43bd68a97c2c42589dfb536062de43752022-12-21T22:59:46ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872017-01-01411606810.4093/dmj.2017.41.1.60Serum Calcium and the Risk of Incident Metabolic Syndrome: A 4.3-Year Retrospective Longitudinal StudyJong Ha Baek0Sang-Man Jin1Ji Cheol Bae2Jae Hwan Jee3Tae Yang Yu4Soo Kyoung Kim5Kyu Yeon Hur6Moon-Kyu Lee7Jae Hyeon Kim8Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.Department of Health Promotion Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.BackgroundAn association between serum calcium level and risk of metabolic syndrome (MetS) has been suggested in cross-sectional studies. This study aimed to evaluate the association between baseline serum calcium level and risk of incident MetS in a longitudinal study.MethodsWe conducted a retrospective longitudinal study of 12,706 participants without MetS who participated in a health screening program, had normal range serum calcium level at baseline (mean age, 51 years), and were followed up for 4.3 years (18,925 person-years). The risk of developing MetS was analyzed according to the baseline serum calcium levels.ResultsA total of 3,448 incident cases (27.1%) of MetS developed during the follow-up period. The hazard ratio (HR) for incident MetS did not increase with increasing tertile of serum calcium level in an age- and sex-matched model (P for trend=0.915). The HRs (95% confidence interval [CI]) for incident MetS comparing the second and the third tertiles to the first tertile of baseline serum calcium level were 0.91 (95% CI, 0.84 to 0.99) and 0.85 (95% CI, 0.78 to 0.92) in a fully adjusted model, respectively (P for trend=0.001). A decreased risk of incident MetS in higher tertiles of serum calcium level was observed in subjects with central obesity and/or a metabolically unhealthy state at baseline.ConclusionThere was no positive correlation between baseline serum calcium levels and incident risk of MetS in this longitudinal study. There was an association between higher serum calcium levels and decreased incident MetS in individuals with central obesity or two components of MetS at baseline.https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-41-60.pdfCalciumLongitudinal studiesMetabolic syndromeObesity, abdominal |
| spellingShingle | Jong Ha Baek Sang-Man Jin Ji Cheol Bae Jae Hwan Jee Tae Yang Yu Soo Kyoung Kim Kyu Yeon Hur Moon-Kyu Lee Jae Hyeon Kim Serum Calcium and the Risk of Incident Metabolic Syndrome: A 4.3-Year Retrospective Longitudinal Study Diabetes & Metabolism Journal Calcium Longitudinal studies Metabolic syndrome Obesity, abdominal |
| title | Serum Calcium and the Risk of Incident Metabolic Syndrome: A 4.3-Year Retrospective Longitudinal Study |
| title_full | Serum Calcium and the Risk of Incident Metabolic Syndrome: A 4.3-Year Retrospective Longitudinal Study |
| title_fullStr | Serum Calcium and the Risk of Incident Metabolic Syndrome: A 4.3-Year Retrospective Longitudinal Study |
| title_full_unstemmed | Serum Calcium and the Risk of Incident Metabolic Syndrome: A 4.3-Year Retrospective Longitudinal Study |
| title_short | Serum Calcium and the Risk of Incident Metabolic Syndrome: A 4.3-Year Retrospective Longitudinal Study |
| title_sort | serum calcium and the risk of incident metabolic syndrome a 4 3 year retrospective longitudinal study |
| topic | Calcium Longitudinal studies Metabolic syndrome Obesity, abdominal |
| url | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-41-60.pdf |
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