Preventive Effect of Glycyrrhiza Glabra Extract on Oral Mucositis in Patients under Head and Neck Radiotherapy: A Randomized Clinical Trial
Objectives: About two-thirds of cancer patients undergo radiotherapy. Oral mucositis represents a major complication of radiotherapy, causing morbidity and mortality and decreasing the quality of life of patients. This study aimed to assess the preventive effect of Glycyrrhiza aqueous extract on ora...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2017-12-01
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| Series: | Frontiers in Dentistry |
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| Online Access: | https://jdt.tums.ac.ir/index.php/jdt/article/view/1717 |
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| author | Shamsolmolok Najafi Soraiya Ebrahimpour Koujan Soheila Manifar Mohammad Javad Kharazifard Saba Kidi Samira Hajheidary |
| author_facet | Shamsolmolok Najafi Soraiya Ebrahimpour Koujan Soheila Manifar Mohammad Javad Kharazifard Saba Kidi Samira Hajheidary |
| author_sort | Shamsolmolok Najafi |
| collection | DOAJ |
| description | Objectives: About two-thirds of cancer patients undergo radiotherapy. Oral mucositis represents a major complication of radiotherapy, causing morbidity and mortality and decreasing the quality of life of patients. This study aimed to assess the preventive effect of Glycyrrhiza aqueous extract on oral mucositis in cancer patients under head and neck radiotherapy.
Materials and Methods: In this double-blind clinical trial, 37 head and neck cancer patients were divided into intervention (n=19) group receiving Glycyrrhiza aqueous extract and control (n=18) group receiving placebo. Patients in the test group used Glycyrrhiza aqueous extract topically twice a day from the first day of starting radiotherapy until the end of the second week. Patients were examined in the first day of radiotherapy for any type of wound before treatment and those with oral ulcers before radiotherapy were excluded from the study. The grade of mucositis was determined using the classification by the World Health Organization. ANCOVA was performed to assess any difference between the two groups with regard to oral mucosal irritation and wound size after the intervention while controlling for the covariates such as sex and age.
Results: Significant differences were found in the maximum grade of mucositis and oral mucosal irritation between the intervention and control groups (P<0.001).
Conclusions: This study showed that aqueous extract of Glycyrrhiza can be effective for decreasing the severity of oral mucositis in head and neck cancer patients undergoing radiotherapy. |
| first_indexed | 2024-04-13T01:17:33Z |
| format | Article |
| id | doaj.art-43be44a95c424e0c819a6cfa4a57eada |
| institution | Directory Open Access Journal |
| issn | 2676-296X |
| language | English |
| last_indexed | 2024-04-13T01:17:33Z |
| publishDate | 2017-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Frontiers in Dentistry |
| spelling | doaj.art-43be44a95c424e0c819a6cfa4a57eada2022-12-22T03:08:52ZengTehran University of Medical SciencesFrontiers in Dentistry2676-296X2017-12-01145935Preventive Effect of Glycyrrhiza Glabra Extract on Oral Mucositis in Patients under Head and Neck Radiotherapy: A Randomized Clinical TrialShamsolmolok Najafi0Soraiya Ebrahimpour Koujan1Soheila Manifar2Mohammad Javad Kharazifard3Saba Kidi4Samira Hajheidary5Assistant Professor, Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, IranPhD Student, Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, IranEpidemiologist, Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, IranDentistry Student, School of Dentistry, International Campus, Tehran University of Medical Sciences, Tehran, IranPostgraduate Student, Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, IranObjectives: About two-thirds of cancer patients undergo radiotherapy. Oral mucositis represents a major complication of radiotherapy, causing morbidity and mortality and decreasing the quality of life of patients. This study aimed to assess the preventive effect of Glycyrrhiza aqueous extract on oral mucositis in cancer patients under head and neck radiotherapy. Materials and Methods: In this double-blind clinical trial, 37 head and neck cancer patients were divided into intervention (n=19) group receiving Glycyrrhiza aqueous extract and control (n=18) group receiving placebo. Patients in the test group used Glycyrrhiza aqueous extract topically twice a day from the first day of starting radiotherapy until the end of the second week. Patients were examined in the first day of radiotherapy for any type of wound before treatment and those with oral ulcers before radiotherapy were excluded from the study. The grade of mucositis was determined using the classification by the World Health Organization. ANCOVA was performed to assess any difference between the two groups with regard to oral mucosal irritation and wound size after the intervention while controlling for the covariates such as sex and age. Results: Significant differences were found in the maximum grade of mucositis and oral mucosal irritation between the intervention and control groups (P<0.001). Conclusions: This study showed that aqueous extract of Glycyrrhiza can be effective for decreasing the severity of oral mucositis in head and neck cancer patients undergoing radiotherapy.https://jdt.tums.ac.ir/index.php/jdt/article/view/1717MucositisGlycyrrhizaRadiotherapyMouth Neoplasms |
| spellingShingle | Shamsolmolok Najafi Soraiya Ebrahimpour Koujan Soheila Manifar Mohammad Javad Kharazifard Saba Kidi Samira Hajheidary Preventive Effect of Glycyrrhiza Glabra Extract on Oral Mucositis in Patients under Head and Neck Radiotherapy: A Randomized Clinical Trial Frontiers in Dentistry Mucositis Glycyrrhiza Radiotherapy Mouth Neoplasms |
| title | Preventive Effect of Glycyrrhiza Glabra Extract on Oral Mucositis in Patients under Head and Neck Radiotherapy: A Randomized Clinical Trial |
| title_full | Preventive Effect of Glycyrrhiza Glabra Extract on Oral Mucositis in Patients under Head and Neck Radiotherapy: A Randomized Clinical Trial |
| title_fullStr | Preventive Effect of Glycyrrhiza Glabra Extract on Oral Mucositis in Patients under Head and Neck Radiotherapy: A Randomized Clinical Trial |
| title_full_unstemmed | Preventive Effect of Glycyrrhiza Glabra Extract on Oral Mucositis in Patients under Head and Neck Radiotherapy: A Randomized Clinical Trial |
| title_short | Preventive Effect of Glycyrrhiza Glabra Extract on Oral Mucositis in Patients under Head and Neck Radiotherapy: A Randomized Clinical Trial |
| title_sort | preventive effect of glycyrrhiza glabra extract on oral mucositis in patients under head and neck radiotherapy a randomized clinical trial |
| topic | Mucositis Glycyrrhiza Radiotherapy Mouth Neoplasms |
| url | https://jdt.tums.ac.ir/index.php/jdt/article/view/1717 |
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