Association between ApoE ε4 Carrier Status and Cardiovascular Risk Factors on Mild Cognitive Impairment among Mexican Older Adults
Mild cognitive impairment (MCI) (amnestic or non-amnestic) has different clinical and neuropsychological characteristics, and its evolution is heterogeneous. Cardiovascular risk factors (CVRF), such as hypertension, diabetes, or dyslipidemia, and the presence of the Apolipoprotein E ε4 (ApoE ε4) pol...
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MDPI AG
2021-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/1/68 |
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| author | Sara G. Aguilar-Navarro Itzel I. Gonzalez-Aparicio José Alberto Avila-Funes Teresa Juárez-Cedillo Teresa Tusié-Luna Alberto Jose Mimenza-Alvarado |
| author_facet | Sara G. Aguilar-Navarro Itzel I. Gonzalez-Aparicio José Alberto Avila-Funes Teresa Juárez-Cedillo Teresa Tusié-Luna Alberto Jose Mimenza-Alvarado |
| author_sort | Sara G. Aguilar-Navarro |
| collection | DOAJ |
| description | Mild cognitive impairment (MCI) (amnestic or non-amnestic) has different clinical and neuropsychological characteristics, and its evolution is heterogeneous. Cardiovascular risk factors (CVRF), such as hypertension, diabetes, or dyslipidemia, and the presence of the Apolipoprotein E ε4 (ApoE ε4) polymorphism have been associated with an increased risk of developing Alzheimer’s disease (AD) and other dementias but the relationship is inconsistent worldwide. We aimed to establish the association between the ApoE ε4 carrier status and CVRF on MCI subtypes (amnestic and non-amnestic) in Mexican older adults. Cross-sectional study including 137 older adults (<i>n</i> = 63 with normal cognition (NC), <i>n</i> = 24 with amnesic, and <i>n</i> = 50 with non-amnesic MCI). Multinomial logistic regression models were performed in order to determine the association between ApoE ε4 polymorphism carrier and CVRF on amnestic and non-amnestic-MCI. ApoE ε4 carrier status was present in 28.8% participants. The models showed that ApoE ε4 carrier status was not associated neither aMCI nor naMCI condition. The interaction term ApoE ε4 × CVRF was not statistically significant for both types of MCI. However, CVRF were associated with both types of MCI and the association remained statistically significant after adjustment by sex, age, and education level. The carrier status of the ApoE genotype does not contribute to this risk. |
| first_indexed | 2024-03-09T05:52:05Z |
| format | Article |
| id | doaj.art-43be561312ff47faa71b9050cca93afc |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T05:52:05Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-43be561312ff47faa71b9050cca93afc2023-12-03T12:16:41ZengMDPI AGBrain Sciences2076-34252021-01-011116810.3390/brainsci11010068Association between ApoE ε4 Carrier Status and Cardiovascular Risk Factors on Mild Cognitive Impairment among Mexican Older AdultsSara G. Aguilar-Navarro0Itzel I. Gonzalez-Aparicio1José Alberto Avila-Funes2Teresa Juárez-Cedillo3Teresa Tusié-Luna4Alberto Jose Mimenza-Alvarado5Department of Geriatric Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoGeriatric Medicine & Neurology Fellowship, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoDepartment of Geriatric Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoEpidemiologic and Health Service Research Unit, Aging Area, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Mexico City 06720, MexicoUnidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán e Instituto de Investigaciones Biomédicas, UNAM, Mexico City 14080, MexicoDepartment of Geriatric Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoMild cognitive impairment (MCI) (amnestic or non-amnestic) has different clinical and neuropsychological characteristics, and its evolution is heterogeneous. Cardiovascular risk factors (CVRF), such as hypertension, diabetes, or dyslipidemia, and the presence of the Apolipoprotein E ε4 (ApoE ε4) polymorphism have been associated with an increased risk of developing Alzheimer’s disease (AD) and other dementias but the relationship is inconsistent worldwide. We aimed to establish the association between the ApoE ε4 carrier status and CVRF on MCI subtypes (amnestic and non-amnestic) in Mexican older adults. Cross-sectional study including 137 older adults (<i>n</i> = 63 with normal cognition (NC), <i>n</i> = 24 with amnesic, and <i>n</i> = 50 with non-amnesic MCI). Multinomial logistic regression models were performed in order to determine the association between ApoE ε4 polymorphism carrier and CVRF on amnestic and non-amnestic-MCI. ApoE ε4 carrier status was present in 28.8% participants. The models showed that ApoE ε4 carrier status was not associated neither aMCI nor naMCI condition. The interaction term ApoE ε4 × CVRF was not statistically significant for both types of MCI. However, CVRF were associated with both types of MCI and the association remained statistically significant after adjustment by sex, age, and education level. The carrier status of the ApoE genotype does not contribute to this risk.https://www.mdpi.com/2076-3425/11/1/68apolipoprotein E ε4cardiovascular risk factorsamnestic MCInon-amnestic MCIMexican Mestizo older adults |
| spellingShingle | Sara G. Aguilar-Navarro Itzel I. Gonzalez-Aparicio José Alberto Avila-Funes Teresa Juárez-Cedillo Teresa Tusié-Luna Alberto Jose Mimenza-Alvarado Association between ApoE ε4 Carrier Status and Cardiovascular Risk Factors on Mild Cognitive Impairment among Mexican Older Adults Brain Sciences apolipoprotein E ε4 cardiovascular risk factors amnestic MCI non-amnestic MCI Mexican Mestizo older adults |
| title | Association between ApoE ε4 Carrier Status and Cardiovascular Risk Factors on Mild Cognitive Impairment among Mexican Older Adults |
| title_full | Association between ApoE ε4 Carrier Status and Cardiovascular Risk Factors on Mild Cognitive Impairment among Mexican Older Adults |
| title_fullStr | Association between ApoE ε4 Carrier Status and Cardiovascular Risk Factors on Mild Cognitive Impairment among Mexican Older Adults |
| title_full_unstemmed | Association between ApoE ε4 Carrier Status and Cardiovascular Risk Factors on Mild Cognitive Impairment among Mexican Older Adults |
| title_short | Association between ApoE ε4 Carrier Status and Cardiovascular Risk Factors on Mild Cognitive Impairment among Mexican Older Adults |
| title_sort | association between apoe ε4 carrier status and cardiovascular risk factors on mild cognitive impairment among mexican older adults |
| topic | apolipoprotein E ε4 cardiovascular risk factors amnestic MCI non-amnestic MCI Mexican Mestizo older adults |
| url | https://www.mdpi.com/2076-3425/11/1/68 |
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