Effects of Laboratory Parameters on Tear Tests and Optical Coherence Tomography Findings in Pediatric Celiac Disease
Aim: The aim of this study was to evaluate the tear parameters and optical coherence tomography (OCT) findings in children with celiac disease (CD) and to investigate the relationship between these findings and laboratory data. Material and Methods: The study included 100 eyes of 50 CD patients as w...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Duzce University
2022-08-01
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| Series: | Düzce Tıp Fakültesi Dergisi |
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| Online Access: | https://dergipark.org.tr/en/download/article-file/2287704 |
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| author | Özlem Tezol Yusuf Usta Ayça Sarı Esra Danacı Vatansever Özer Dursun Mustafa Vatansever Erdem Dinç |
| author_facet | Özlem Tezol Yusuf Usta Ayça Sarı Esra Danacı Vatansever Özer Dursun Mustafa Vatansever Erdem Dinç |
| author_sort | Özlem Tezol |
| collection | DOAJ |
| description | Aim: The aim of this study was to evaluate the tear parameters and optical coherence tomography (OCT) findings in children with celiac disease (CD) and to investigate the relationship between these findings and laboratory data.
Material and Methods: The study included 100 eyes of 50 CD patients as well as 110 eyes of 55 healthy subjects with no ocular pathology as a control group. Best corrected visual acuity was evaluated, baseline tear volume was estimated using standard Schirmer’s test, and fluorescein tear film break-up time (TBUT) was determined for all participants. Pupillary dilation was induced and macular sections and optic disc sections were obtained with OCT.
Results: The patient and control groups showed no statistically significant differences in terms of age and gender distribution (p=0.490, and p=0.930, respectively). Mean Schirmer’s test measurement was significantly lower in the CD patients compared to the control group (14.07±5.14 mm vs. 20.20±3.93 mm, p<0.001). TBUT was also shorter in the CD patients compared to the control subjects (10.86±3.51 s vs. 15.25±2.49 s, p<0.001). Mean total retinal thickness and outer retinal thickness values were significantly lower in the patient group than in the control group (p<0.001, for both parameters). In addition, the mean retinal nerve fiber layer (RNFL) thickness measurement was significantly thinner in the patient group than in the control group (p<0.001).
Conclusion: In the presented study, it was observed that macular and RNFL thickness were decreased in children with CD compared to the control group, and tear tests were also impaired. |
| first_indexed | 2024-03-09T08:27:29Z |
| format | Article |
| id | doaj.art-43bead2f03454428bb0827fcacefc0c5 |
| institution | Directory Open Access Journal |
| issn | 1307-671X |
| language | English |
| last_indexed | 2024-03-09T08:27:29Z |
| publishDate | 2022-08-01 |
| publisher | Duzce University |
| record_format | Article |
| series | Düzce Tıp Fakültesi Dergisi |
| spelling | doaj.art-43bead2f03454428bb0827fcacefc0c52023-12-02T20:50:31ZengDuzce UniversityDüzce Tıp Fakültesi Dergisi1307-671X2022-08-0124212112510.18678/dtfd.108230097Effects of Laboratory Parameters on Tear Tests and Optical Coherence Tomography Findings in Pediatric Celiac DiseaseÖzlem Tezol0Yusuf Usta1Ayça Sarı2Esra Danacı Vatansever3Özer Dursun4Mustafa Vatansever5Erdem Dinç6MERSİN ÜNİVERSİTESİ, TIP FAKÜLTESİMERSİN ÜNİVERSİTESİ, TIP FAKÜLTESİMERSİN ÜNİVERSİTESİ, TIP FAKÜLTESİMERSİN ÜNİVERSİTESİ, TIP FAKÜLTESİMERSİN ÜNİVERSİTESİ, TIP FAKÜLTESİMERSİN ÜNİVERSİTESİ, TIP FAKÜLTESİMersin Üniversitesi, Tıp Fakültesi, Göz Hastalıkları ADAim: The aim of this study was to evaluate the tear parameters and optical coherence tomography (OCT) findings in children with celiac disease (CD) and to investigate the relationship between these findings and laboratory data. Material and Methods: The study included 100 eyes of 50 CD patients as well as 110 eyes of 55 healthy subjects with no ocular pathology as a control group. Best corrected visual acuity was evaluated, baseline tear volume was estimated using standard Schirmer’s test, and fluorescein tear film break-up time (TBUT) was determined for all participants. Pupillary dilation was induced and macular sections and optic disc sections were obtained with OCT. Results: The patient and control groups showed no statistically significant differences in terms of age and gender distribution (p=0.490, and p=0.930, respectively). Mean Schirmer’s test measurement was significantly lower in the CD patients compared to the control group (14.07±5.14 mm vs. 20.20±3.93 mm, p<0.001). TBUT was also shorter in the CD patients compared to the control subjects (10.86±3.51 s vs. 15.25±2.49 s, p<0.001). Mean total retinal thickness and outer retinal thickness values were significantly lower in the patient group than in the control group (p<0.001, for both parameters). In addition, the mean retinal nerve fiber layer (RNFL) thickness measurement was significantly thinner in the patient group than in the control group (p<0.001). Conclusion: In the presented study, it was observed that macular and RNFL thickness were decreased in children with CD compared to the control group, and tear tests were also impaired.https://dergipark.org.tr/en/download/article-file/2287704celiac diseaselaboratory parameterstear filmoptical coherence tomographypediatric patientsçölyak hastalığılaboratuar parametrelerigözyaşı filmioptik koherens tomografiçocuk hastalar |
| spellingShingle | Özlem Tezol Yusuf Usta Ayça Sarı Esra Danacı Vatansever Özer Dursun Mustafa Vatansever Erdem Dinç Effects of Laboratory Parameters on Tear Tests and Optical Coherence Tomography Findings in Pediatric Celiac Disease Düzce Tıp Fakültesi Dergisi celiac disease laboratory parameters tear film optical coherence tomography pediatric patients çölyak hastalığı laboratuar parametreleri gözyaşı filmi optik koherens tomografi çocuk hastalar |
| title | Effects of Laboratory Parameters on Tear Tests and Optical Coherence Tomography Findings in Pediatric Celiac Disease |
| title_full | Effects of Laboratory Parameters on Tear Tests and Optical Coherence Tomography Findings in Pediatric Celiac Disease |
| title_fullStr | Effects of Laboratory Parameters on Tear Tests and Optical Coherence Tomography Findings in Pediatric Celiac Disease |
| title_full_unstemmed | Effects of Laboratory Parameters on Tear Tests and Optical Coherence Tomography Findings in Pediatric Celiac Disease |
| title_short | Effects of Laboratory Parameters on Tear Tests and Optical Coherence Tomography Findings in Pediatric Celiac Disease |
| title_sort | effects of laboratory parameters on tear tests and optical coherence tomography findings in pediatric celiac disease |
| topic | celiac disease laboratory parameters tear film optical coherence tomography pediatric patients çölyak hastalığı laboratuar parametreleri gözyaşı filmi optik koherens tomografi çocuk hastalar |
| url | https://dergipark.org.tr/en/download/article-file/2287704 |
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