High Hepatitis E Virus (HEV) Seroprevalence and No Evidence of HEV Viraemia in Vietnamese Blood Donors
The prevalence of hepatitis E virus (HEV) in the Vietnamese population remains underestimated. The aim of the present study was to investigate the seroprevalence of HEV IgG/IgM antibodies and the presence of HEV RNA in blood donors as a part of epidemiological surveillance for transfusion-transmitte...
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| Format: | Article |
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MDPI AG
2023-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/10/2075 |
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| author | Le Chi Cao Vanessa Martin Le Thi Kieu Linh Tran Thi Giang Ngo Thi Minh Chau Ton Nu Phuong Anh Vu Xuan Nghia Nguyen Trong The Truong Nhat My Bui Tien Sy Nguyen Linh Toan Le Huu Song C.-Thomas Bock Thirumalaisamy P. Velavan |
| author_facet | Le Chi Cao Vanessa Martin Le Thi Kieu Linh Tran Thi Giang Ngo Thi Minh Chau Ton Nu Phuong Anh Vu Xuan Nghia Nguyen Trong The Truong Nhat My Bui Tien Sy Nguyen Linh Toan Le Huu Song C.-Thomas Bock Thirumalaisamy P. Velavan |
| author_sort | Le Chi Cao |
| collection | DOAJ |
| description | The prevalence of hepatitis E virus (HEV) in the Vietnamese population remains underestimated. The aim of the present study was to investigate the seroprevalence of HEV IgG/IgM antibodies and the presence of HEV RNA in blood donors as a part of epidemiological surveillance for transfusion-transmitted viruses. Serum samples from blood donors (<i>n</i> = 553) were analysed for markers of past (anti-HEV IgG) and recent/ongoing (anti-HEV IgM) HEV infections. In addition, all serum samples were subsequently tested for HEV RNA positivity. The overall prevalence of anti-HEV IgG was 26.8% (<i>n</i> = 148/553), while the seroprevalence of anti-HEV IgM was 0.5% (<i>n</i> = 3/553). Anti-HEV IgG seroprevalence in male and female donors was similar (27.1% and 25.5%, respectively). A higher risk of hepatitis E exposure was observed with increasing age. None of the blood donors were HEV RNA positive, and there was no evidence of HEV viraemia. Although the absence of HEV viraemia in blood donors from Northern Vietnam is encouraging, further epidemiological surveillance in other geographical regions is warranted to rule out transfusion-transmitted HEV. |
| first_indexed | 2024-03-10T20:49:45Z |
| format | Article |
| id | doaj.art-43c22db323734c7abe7f199f8b42e282 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T20:49:45Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-43c22db323734c7abe7f199f8b42e2822023-11-19T18:27:54ZengMDPI AGViruses1999-49152023-10-011510207510.3390/v15102075High Hepatitis E Virus (HEV) Seroprevalence and No Evidence of HEV Viraemia in Vietnamese Blood DonorsLe Chi Cao0Vanessa Martin1Le Thi Kieu Linh2Tran Thi Giang3Ngo Thi Minh Chau4Ton Nu Phuong Anh5Vu Xuan Nghia6Nguyen Trong The7Truong Nhat My8Bui Tien Sy9Nguyen Linh Toan10Le Huu Song11C.-Thomas Bock12Thirumalaisamy P. Velavan13Institute of Tropical Medicine, University of Tübingen, 72074 Tübingen, GermanyInstitute of Tropical Medicine, University of Tübingen, 72074 Tübingen, GermanyInstitute of Tropical Medicine, University of Tübingen, 72074 Tübingen, GermanyDepartment of Parasitology, Hue University of Medicine and Pharmacy (HUMP), Hue University, Hue 49000, VietnamDepartment of Parasitology, Hue University of Medicine and Pharmacy (HUMP), Hue University, Hue 49000, VietnamDepartment of Parasitology, Hue University of Medicine and Pharmacy (HUMP), Hue University, Hue 49000, Vietnam108 Military Central Hospital, Hanoi 10000, VietnamVietnamese-German Center for Medical Research (VG-CARE), Hanoi 10000, VietnamVietnamese-German Center for Medical Research (VG-CARE), Hanoi 10000, VietnamVietnamese-German Center for Medical Research (VG-CARE), Hanoi 10000, VietnamDepartment of Pathophysiology, Vietnam Military Medical University, Hanoi 10000, VietnamVietnamese-German Center for Medical Research (VG-CARE), Hanoi 10000, VietnamInstitute of Tropical Medicine, University of Tübingen, 72074 Tübingen, GermanyInstitute of Tropical Medicine, University of Tübingen, 72074 Tübingen, GermanyThe prevalence of hepatitis E virus (HEV) in the Vietnamese population remains underestimated. The aim of the present study was to investigate the seroprevalence of HEV IgG/IgM antibodies and the presence of HEV RNA in blood donors as a part of epidemiological surveillance for transfusion-transmitted viruses. Serum samples from blood donors (<i>n</i> = 553) were analysed for markers of past (anti-HEV IgG) and recent/ongoing (anti-HEV IgM) HEV infections. In addition, all serum samples were subsequently tested for HEV RNA positivity. The overall prevalence of anti-HEV IgG was 26.8% (<i>n</i> = 148/553), while the seroprevalence of anti-HEV IgM was 0.5% (<i>n</i> = 3/553). Anti-HEV IgG seroprevalence in male and female donors was similar (27.1% and 25.5%, respectively). A higher risk of hepatitis E exposure was observed with increasing age. None of the blood donors were HEV RNA positive, and there was no evidence of HEV viraemia. Although the absence of HEV viraemia in blood donors from Northern Vietnam is encouraging, further epidemiological surveillance in other geographical regions is warranted to rule out transfusion-transmitted HEV.https://www.mdpi.com/1999-4915/15/10/2075hepatitis E virusblood donorstransfusionseroprevalence |
| spellingShingle | Le Chi Cao Vanessa Martin Le Thi Kieu Linh Tran Thi Giang Ngo Thi Minh Chau Ton Nu Phuong Anh Vu Xuan Nghia Nguyen Trong The Truong Nhat My Bui Tien Sy Nguyen Linh Toan Le Huu Song C.-Thomas Bock Thirumalaisamy P. Velavan High Hepatitis E Virus (HEV) Seroprevalence and No Evidence of HEV Viraemia in Vietnamese Blood Donors Viruses hepatitis E virus blood donors transfusion seroprevalence |
| title | High Hepatitis E Virus (HEV) Seroprevalence and No Evidence of HEV Viraemia in Vietnamese Blood Donors |
| title_full | High Hepatitis E Virus (HEV) Seroprevalence and No Evidence of HEV Viraemia in Vietnamese Blood Donors |
| title_fullStr | High Hepatitis E Virus (HEV) Seroprevalence and No Evidence of HEV Viraemia in Vietnamese Blood Donors |
| title_full_unstemmed | High Hepatitis E Virus (HEV) Seroprevalence and No Evidence of HEV Viraemia in Vietnamese Blood Donors |
| title_short | High Hepatitis E Virus (HEV) Seroprevalence and No Evidence of HEV Viraemia in Vietnamese Blood Donors |
| title_sort | high hepatitis e virus hev seroprevalence and no evidence of hev viraemia in vietnamese blood donors |
| topic | hepatitis E virus blood donors transfusion seroprevalence |
| url | https://www.mdpi.com/1999-4915/15/10/2075 |
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