The Role of Human Satellite III (1q12) Copy Number Variation in the Adaptive Response during Aging, Stress, and Pathology: A Pendulum Model
The pericentric satellite III (SatIII or Sat3) and II tandem repeats recently appeared to be transcribed under stress conditions, and the transcripts were shown to play an essential role in the universal stress response. In this paper, we review the role of human-specific SatIII copy number variatio...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/10/1524 |
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| author | Lev N. Porokhovnik Natalia N. Veiko Elizaveta S. Ershova Svetlana V. Kostyuk |
| author_facet | Lev N. Porokhovnik Natalia N. Veiko Elizaveta S. Ershova Svetlana V. Kostyuk |
| author_sort | Lev N. Porokhovnik |
| collection | DOAJ |
| description | The pericentric satellite III (SatIII or Sat3) and II tandem repeats recently appeared to be transcribed under stress conditions, and the transcripts were shown to play an essential role in the universal stress response. In this paper, we review the role of human-specific SatIII copy number variation (CNV) in normal stress response, aging and pathology, with a focus on 1q12 loci. We postulate a close link between transcription of SatII/III repeats and their CNV. The accrued body of data suggests a hypothetical universal mechanism, which provides for SatIII copy gain during the stress response, alongside with another, more hypothetical reverse mechanism that might reduce the mean SatIII copy number, likely via the selection of cells with excessively large 1q12 loci. Both mechanisms, working alternatively like swings of the pendulum, may ensure the balance of SatIII copy numbers and optimum stress resistance. This model is verified on the most recent data on SatIII CNV in pathology and therapy, aging, senescence and response to genotoxic stress in vitro. |
| first_indexed | 2024-03-10T06:32:34Z |
| format | Article |
| id | doaj.art-43c33ebaa72b4e34afcbe645844d7454 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T06:32:34Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-43c33ebaa72b4e34afcbe645844d74542023-11-22T18:21:19ZengMDPI AGGenes2073-44252021-09-011210152410.3390/genes12101524The Role of Human Satellite III (1q12) Copy Number Variation in the Adaptive Response during Aging, Stress, and Pathology: A Pendulum ModelLev N. Porokhovnik0Natalia N. Veiko1Elizaveta S. Ershova2Svetlana V. Kostyuk3Laboratory of Molecular Biology, Research Centre for Medical Genetics, 115478 Moscow, RussiaLaboratory of Molecular Biology, Research Centre for Medical Genetics, 115478 Moscow, RussiaLaboratory of Molecular Biology, Research Centre for Medical Genetics, 115478 Moscow, RussiaLaboratory of Molecular Biology, Research Centre for Medical Genetics, 115478 Moscow, RussiaThe pericentric satellite III (SatIII or Sat3) and II tandem repeats recently appeared to be transcribed under stress conditions, and the transcripts were shown to play an essential role in the universal stress response. In this paper, we review the role of human-specific SatIII copy number variation (CNV) in normal stress response, aging and pathology, with a focus on 1q12 loci. We postulate a close link between transcription of SatII/III repeats and their CNV. The accrued body of data suggests a hypothetical universal mechanism, which provides for SatIII copy gain during the stress response, alongside with another, more hypothetical reverse mechanism that might reduce the mean SatIII copy number, likely via the selection of cells with excessively large 1q12 loci. Both mechanisms, working alternatively like swings of the pendulum, may ensure the balance of SatIII copy numbers and optimum stress resistance. This model is verified on the most recent data on SatIII CNV in pathology and therapy, aging, senescence and response to genotoxic stress in vitro.https://www.mdpi.com/2073-4425/12/10/1524repetitive sequencessatellite III1q12copy number variationcopy gainnon-coding RNA |
| spellingShingle | Lev N. Porokhovnik Natalia N. Veiko Elizaveta S. Ershova Svetlana V. Kostyuk The Role of Human Satellite III (1q12) Copy Number Variation in the Adaptive Response during Aging, Stress, and Pathology: A Pendulum Model Genes repetitive sequences satellite III 1q12 copy number variation copy gain non-coding RNA |
| title | The Role of Human Satellite III (1q12) Copy Number Variation in the Adaptive Response during Aging, Stress, and Pathology: A Pendulum Model |
| title_full | The Role of Human Satellite III (1q12) Copy Number Variation in the Adaptive Response during Aging, Stress, and Pathology: A Pendulum Model |
| title_fullStr | The Role of Human Satellite III (1q12) Copy Number Variation in the Adaptive Response during Aging, Stress, and Pathology: A Pendulum Model |
| title_full_unstemmed | The Role of Human Satellite III (1q12) Copy Number Variation in the Adaptive Response during Aging, Stress, and Pathology: A Pendulum Model |
| title_short | The Role of Human Satellite III (1q12) Copy Number Variation in the Adaptive Response during Aging, Stress, and Pathology: A Pendulum Model |
| title_sort | role of human satellite iii 1q12 copy number variation in the adaptive response during aging stress and pathology a pendulum model |
| topic | repetitive sequences satellite III 1q12 copy number variation copy gain non-coding RNA |
| url | https://www.mdpi.com/2073-4425/12/10/1524 |
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