Recent Developments in the Interactions of Classic Intercalated Ruthenium Compounds: [Ru(bpy)<sub>2</sub>dppz]<sup>2+</sup> and [Ru(phen)<sub>2</sub>dppz]<sup>2+</sup> with a DNA Molecule
[Ru(bpy)<sub>2</sub>dppz]<sup>2+</sup> and [Ru(phen)<sub>2</sub>dppz]<sup>2+</sup> as the light switches of the deoxyribose nucleic acid (DNA) molecule have attracted much attention and have become a powerful tool for exploring the structure of the DNA...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/4/769 |
| _version_ | 1819207582085021696 |
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| author | Fuchao Jia Shuo Wang Yan Man Parveen Kumar Bo Liu |
| author_facet | Fuchao Jia Shuo Wang Yan Man Parveen Kumar Bo Liu |
| author_sort | Fuchao Jia |
| collection | DOAJ |
| description | [Ru(bpy)<sub>2</sub>dppz]<sup>2+</sup> and [Ru(phen)<sub>2</sub>dppz]<sup>2+</sup> as the light switches of the deoxyribose nucleic acid (DNA) molecule have attracted much attention and have become a powerful tool for exploring the structure of the DNA helix. Their interactions have been intensively studied because of the excellent photophysical and photochemical properties of ruthenium compounds. In this perspective, this review describes the recent developments in the interactions of these two classic intercalated compounds with a DNA helix. The mechanism of the molecular light switch effect and the selectivity of these two compounds to different forms of a DNA helix has been discussed. In addition, the specific binding modes between them have been discussed in detail, for a better understanding the mechanism of the light switch and the luminescence difference. Finally, recent studies of single molecule force spectroscopy have also been included so as to precisely interpret the kinetics, equilibrium constants, and the energy landscape during the process of the dynamic assembly of ligands into a single DNA helix. |
| first_indexed | 2024-12-23T05:25:47Z |
| format | Article |
| id | doaj.art-43c7799fd60d4852a4d2e708a3c0025b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-23T05:25:47Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-43c7799fd60d4852a4d2e708a3c0025b2022-12-21T17:58:36ZengMDPI AGMolecules1420-30492019-02-0124476910.3390/molecules24040769molecules24040769Recent Developments in the Interactions of Classic Intercalated Ruthenium Compounds: [Ru(bpy)<sub>2</sub>dppz]<sup>2+</sup> and [Ru(phen)<sub>2</sub>dppz]<sup>2+</sup> with a DNA MoleculeFuchao Jia0Shuo Wang1Yan Man2Parveen Kumar3Bo Liu4Laboratory of Functional Molecules and Materials, School of Physics and Optoelectronic Engineering, Shandong University of Technology, Zibo 255000, ChinaLaboratory of Functional Molecules and Materials, School of Physics and Optoelectronic Engineering, Shandong University of Technology, Zibo 255000, ChinaBeijing Research Center for Agricultural Standards and Testing, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, ChinaLaboratory of Functional Molecules and Materials, School of Physics and Optoelectronic Engineering, Shandong University of Technology, Zibo 255000, ChinaLaboratory of Functional Molecules and Materials, School of Physics and Optoelectronic Engineering, Shandong University of Technology, Zibo 255000, China[Ru(bpy)<sub>2</sub>dppz]<sup>2+</sup> and [Ru(phen)<sub>2</sub>dppz]<sup>2+</sup> as the light switches of the deoxyribose nucleic acid (DNA) molecule have attracted much attention and have become a powerful tool for exploring the structure of the DNA helix. Their interactions have been intensively studied because of the excellent photophysical and photochemical properties of ruthenium compounds. In this perspective, this review describes the recent developments in the interactions of these two classic intercalated compounds with a DNA helix. The mechanism of the molecular light switch effect and the selectivity of these two compounds to different forms of a DNA helix has been discussed. In addition, the specific binding modes between them have been discussed in detail, for a better understanding the mechanism of the light switch and the luminescence difference. Finally, recent studies of single molecule force spectroscopy have also been included so as to precisely interpret the kinetics, equilibrium constants, and the energy landscape during the process of the dynamic assembly of ligands into a single DNA helix.https://www.mdpi.com/1420-3049/24/4/769intercalated ruthenium compoundsmolecular light switchsensitive luminescent reporterbinding modesingle molecule force spectroscopy |
| spellingShingle | Fuchao Jia Shuo Wang Yan Man Parveen Kumar Bo Liu Recent Developments in the Interactions of Classic Intercalated Ruthenium Compounds: [Ru(bpy)<sub>2</sub>dppz]<sup>2+</sup> and [Ru(phen)<sub>2</sub>dppz]<sup>2+</sup> with a DNA Molecule Molecules intercalated ruthenium compounds molecular light switch sensitive luminescent reporter binding mode single molecule force spectroscopy |
| title | Recent Developments in the Interactions of Classic Intercalated Ruthenium Compounds: [Ru(bpy)<sub>2</sub>dppz]<sup>2+</sup> and [Ru(phen)<sub>2</sub>dppz]<sup>2+</sup> with a DNA Molecule |
| title_full | Recent Developments in the Interactions of Classic Intercalated Ruthenium Compounds: [Ru(bpy)<sub>2</sub>dppz]<sup>2+</sup> and [Ru(phen)<sub>2</sub>dppz]<sup>2+</sup> with a DNA Molecule |
| title_fullStr | Recent Developments in the Interactions of Classic Intercalated Ruthenium Compounds: [Ru(bpy)<sub>2</sub>dppz]<sup>2+</sup> and [Ru(phen)<sub>2</sub>dppz]<sup>2+</sup> with a DNA Molecule |
| title_full_unstemmed | Recent Developments in the Interactions of Classic Intercalated Ruthenium Compounds: [Ru(bpy)<sub>2</sub>dppz]<sup>2+</sup> and [Ru(phen)<sub>2</sub>dppz]<sup>2+</sup> with a DNA Molecule |
| title_short | Recent Developments in the Interactions of Classic Intercalated Ruthenium Compounds: [Ru(bpy)<sub>2</sub>dppz]<sup>2+</sup> and [Ru(phen)<sub>2</sub>dppz]<sup>2+</sup> with a DNA Molecule |
| title_sort | recent developments in the interactions of classic intercalated ruthenium compounds ru bpy sub 2 sub dppz sup 2 sup and ru phen sub 2 sub dppz sup 2 sup with a dna molecule |
| topic | intercalated ruthenium compounds molecular light switch sensitive luminescent reporter binding mode single molecule force spectroscopy |
| url | https://www.mdpi.com/1420-3049/24/4/769 |
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