Potential Association of <i>Cutibacterium acnes</i> with Sarcoidosis as an Endogenous Hypersensitivity Infection
The immunohistochemical detection of <i>Cutibacterium acnes</i> in sarcoid granulomas suggests its potential role in granuloma formation. <i>C. acnes</i> is the sole microorganism ever isolated from sarcoid lesions. Histopathologic analysis of some sarcoid lymph nodes reveals...
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MDPI AG
2023-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/2/289 |
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| author | Yoshinobu Eishi |
| author_facet | Yoshinobu Eishi |
| author_sort | Yoshinobu Eishi |
| collection | DOAJ |
| description | The immunohistochemical detection of <i>Cutibacterium acnes</i> in sarcoid granulomas suggests its potential role in granuloma formation. <i>C. acnes</i> is the sole microorganism ever isolated from sarcoid lesions. Histopathologic analysis of some sarcoid lymph nodes reveals latent infection and intracellular proliferation of cell-wall-deficient <i>C. acnes</i> followed by insoluble immune-complex formation. Activation of T helper type 1 (Th1) immune responses by <i>C. acnes</i> is generally higher in sarcoidosis patients than in healthy individuals. Pulmonary granulomatosis caused by an experimental adjuvant-induced allergic immune response to <i>C. acnes</i> is preventable by antimicrobials, suggesting that the allergic reaction targets <i>C. acnes</i> commensal in the lungs. <i>C. acnes</i> is the most common bacterium detected intracellularly in human peripheral lungs and mediastinal lymph nodes. Some sarcoidosis patients have increased amounts of <i>C. acnes</i>-derived circulating immune complexes, which suggests the proliferation of <i>C. acnes</i> in affected organs. In predisposed individuals with hypersensitive Th1 immune responses to <i>C. acnes</i>, granulomas may form to confine the intracellular proliferation of latent <i>C. acnes</i> triggered by certain host-related or drug-induced conditions. Current clinical trials in patients with cardiac sarcoidosis are evaluating combined treatment with steroids and antimicrobials during active disease with continued antimicrobial therapy while tapering off steroids after the disease subsides. |
| first_indexed | 2024-03-11T08:24:00Z |
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| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-11T08:24:00Z |
| publishDate | 2023-01-01 |
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| series | Microorganisms |
| spelling | doaj.art-43ca60c76a3446469729f6187da3eb212023-11-16T22:13:51ZengMDPI AGMicroorganisms2076-26072023-01-0111228910.3390/microorganisms11020289Potential Association of <i>Cutibacterium acnes</i> with Sarcoidosis as an Endogenous Hypersensitivity InfectionYoshinobu Eishi0Department of Human Pathology, Graduate School, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, JapanThe immunohistochemical detection of <i>Cutibacterium acnes</i> in sarcoid granulomas suggests its potential role in granuloma formation. <i>C. acnes</i> is the sole microorganism ever isolated from sarcoid lesions. Histopathologic analysis of some sarcoid lymph nodes reveals latent infection and intracellular proliferation of cell-wall-deficient <i>C. acnes</i> followed by insoluble immune-complex formation. Activation of T helper type 1 (Th1) immune responses by <i>C. acnes</i> is generally higher in sarcoidosis patients than in healthy individuals. Pulmonary granulomatosis caused by an experimental adjuvant-induced allergic immune response to <i>C. acnes</i> is preventable by antimicrobials, suggesting that the allergic reaction targets <i>C. acnes</i> commensal in the lungs. <i>C. acnes</i> is the most common bacterium detected intracellularly in human peripheral lungs and mediastinal lymph nodes. Some sarcoidosis patients have increased amounts of <i>C. acnes</i>-derived circulating immune complexes, which suggests the proliferation of <i>C. acnes</i> in affected organs. In predisposed individuals with hypersensitive Th1 immune responses to <i>C. acnes</i>, granulomas may form to confine the intracellular proliferation of latent <i>C. acnes</i> triggered by certain host-related or drug-induced conditions. Current clinical trials in patients with cardiac sarcoidosis are evaluating combined treatment with steroids and antimicrobials during active disease with continued antimicrobial therapy while tapering off steroids after the disease subsides.https://www.mdpi.com/2076-2607/11/2/289<i>Cutibacterium acnes</i><i>Propionibacterium acnes</i>sarcoidosisgranulomapathogenesislatent infection |
| spellingShingle | Yoshinobu Eishi Potential Association of <i>Cutibacterium acnes</i> with Sarcoidosis as an Endogenous Hypersensitivity Infection Microorganisms <i>Cutibacterium acnes</i> <i>Propionibacterium acnes</i> sarcoidosis granuloma pathogenesis latent infection |
| title | Potential Association of <i>Cutibacterium acnes</i> with Sarcoidosis as an Endogenous Hypersensitivity Infection |
| title_full | Potential Association of <i>Cutibacterium acnes</i> with Sarcoidosis as an Endogenous Hypersensitivity Infection |
| title_fullStr | Potential Association of <i>Cutibacterium acnes</i> with Sarcoidosis as an Endogenous Hypersensitivity Infection |
| title_full_unstemmed | Potential Association of <i>Cutibacterium acnes</i> with Sarcoidosis as an Endogenous Hypersensitivity Infection |
| title_short | Potential Association of <i>Cutibacterium acnes</i> with Sarcoidosis as an Endogenous Hypersensitivity Infection |
| title_sort | potential association of i cutibacterium acnes i with sarcoidosis as an endogenous hypersensitivity infection |
| topic | <i>Cutibacterium acnes</i> <i>Propionibacterium acnes</i> sarcoidosis granuloma pathogenesis latent infection |
| url | https://www.mdpi.com/2076-2607/11/2/289 |
| work_keys_str_mv | AT yoshinobueishi potentialassociationoficutibacteriumacnesiwithsarcoidosisasanendogenoushypersensitivityinfection |