Fully Implantable Neurostimulation System for Long-Term Behavioral Animal Study
Spinal cord stimulation (SCS) is an emerging therapeutic option for patients with neuropathic pain due to spinal cord injury (SCI). Numerous studies on pain relief effects with SCS have been conducted and demonstrated promising results while the mechanisms of analgesic effect during SCS remain uncle...
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| Format: | Article |
| Language: | English |
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IEEE
2023-01-01
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| Series: | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/10251464/ |
| _version_ | 1797676742558613504 |
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| author | Wonok Kang Jinseung Lee Wonsuk Choi Jinseok Kim Junesun Kim Sung-Min Park |
| author_facet | Wonok Kang Jinseung Lee Wonsuk Choi Jinseok Kim Junesun Kim Sung-Min Park |
| author_sort | Wonok Kang |
| collection | DOAJ |
| description | Spinal cord stimulation (SCS) is an emerging therapeutic option for patients with neuropathic pain due to spinal cord injury (SCI). Numerous studies on pain relief effects with SCS have been conducted and demonstrated promising results while the mechanisms of analgesic effect during SCS remain unclear. However, an experimental system that enables large-scale long-term animal studies is still an unmet need for those mechanistic studies. This study proposed a fully wireless neurostimulation system that can efficiently support a long-term animal study for neuropathic pain relief. The developed system consists of an implantable stimulator, an animal cage with an external charging coil, and a wireless communication interface. The proposed device has the feature of remotely controlling stimulation parameters via radio-frequency (RF) communication and wirelessly charging via magnetic induction in freely moving rats. Users can program stimulation parameters such as pulse width, intensity, and duration through an interface on a computer. The stimulator was packaged with biocompatible epoxy to ensure long-term durability under in vivo conditions. Animal experiments using SCI rats were conducted to demonstrate the functionality of the device, including long-term usability and therapeutic effects. The developed system can be tailored to individual user needs with commercially available components, thus providing a cost-effective solution for large-scale long-term animal studies on neuropathic pain relief. |
| first_indexed | 2024-03-11T22:34:20Z |
| format | Article |
| id | doaj.art-43cfae93735e4b639d01efe0c3e9e42f |
| institution | Directory Open Access Journal |
| issn | 1558-0210 |
| language | English |
| last_indexed | 2024-03-11T22:34:20Z |
| publishDate | 2023-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| spelling | doaj.art-43cfae93735e4b639d01efe0c3e9e42f2023-09-22T23:00:04ZengIEEEIEEE Transactions on Neural Systems and Rehabilitation Engineering1558-02102023-01-01313711372110.1109/TNSRE.2023.331537110251464Fully Implantable Neurostimulation System for Long-Term Behavioral Animal StudyWonok Kang0https://orcid.org/0000-0001-8372-4140Jinseung Lee1Wonsuk Choi2https://orcid.org/0000-0002-8224-5807Jinseok Kim3https://orcid.org/0000-0002-4778-8144Junesun Kim4Sung-Min Park5https://orcid.org/0000-0002-8359-8110Department of Health Science, and the Transdisciplinary Major in Learning Health Systems, Department of Healthcare Science, Graduate School, Rehabilitation Science Program, Korea University, Seoul, South KoreaCenter for Bionics, Korea Institute of Science and Technology, Seoul, South KoreaSchool of Biomedical Engineering, Korea University, Seoul, South KoreaSchool of Biomedical Engineering, Korea University, Seoul, South KoreaDepartment of Health Science, the Transdisciplinary Major in Learning Health Systems, Department of Healthcare Science, Graduate School, and the Department of Health and Environmental Science, Undergraduate School, Rehabilitation Science Program, Korea University, Seoul, South KoreaDepartment of Convergence IT Engineering, the Department of Electrical Engineering, the Department of Mechanical Engineering, and the Medical Device Innovation Center, Pohang University of Science and Technology, Pohang, South KoreaSpinal cord stimulation (SCS) is an emerging therapeutic option for patients with neuropathic pain due to spinal cord injury (SCI). Numerous studies on pain relief effects with SCS have been conducted and demonstrated promising results while the mechanisms of analgesic effect during SCS remain unclear. However, an experimental system that enables large-scale long-term animal studies is still an unmet need for those mechanistic studies. This study proposed a fully wireless neurostimulation system that can efficiently support a long-term animal study for neuropathic pain relief. The developed system consists of an implantable stimulator, an animal cage with an external charging coil, and a wireless communication interface. The proposed device has the feature of remotely controlling stimulation parameters via radio-frequency (RF) communication and wirelessly charging via magnetic induction in freely moving rats. Users can program stimulation parameters such as pulse width, intensity, and duration through an interface on a computer. The stimulator was packaged with biocompatible epoxy to ensure long-term durability under in vivo conditions. Animal experiments using SCI rats were conducted to demonstrate the functionality of the device, including long-term usability and therapeutic effects. The developed system can be tailored to individual user needs with commercially available components, thus providing a cost-effective solution for large-scale long-term animal studies on neuropathic pain relief.https://ieeexplore.ieee.org/document/10251464/Spinal cord stimulation (SCS)spinal cord injury (SCI)pain reliefimplantable stimulatorsurvival study |
| spellingShingle | Wonok Kang Jinseung Lee Wonsuk Choi Jinseok Kim Junesun Kim Sung-Min Park Fully Implantable Neurostimulation System for Long-Term Behavioral Animal Study IEEE Transactions on Neural Systems and Rehabilitation Engineering Spinal cord stimulation (SCS) spinal cord injury (SCI) pain relief implantable stimulator survival study |
| title | Fully Implantable Neurostimulation System for Long-Term Behavioral Animal Study |
| title_full | Fully Implantable Neurostimulation System for Long-Term Behavioral Animal Study |
| title_fullStr | Fully Implantable Neurostimulation System for Long-Term Behavioral Animal Study |
| title_full_unstemmed | Fully Implantable Neurostimulation System for Long-Term Behavioral Animal Study |
| title_short | Fully Implantable Neurostimulation System for Long-Term Behavioral Animal Study |
| title_sort | fully implantable neurostimulation system for long term behavioral animal study |
| topic | Spinal cord stimulation (SCS) spinal cord injury (SCI) pain relief implantable stimulator survival study |
| url | https://ieeexplore.ieee.org/document/10251464/ |
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