Impact of premature ovarian failure on mortality and morbidity among Chinese women.
<h4>Objective</h4>To evaluate associations of premature ovarian failure (POF) with mortality and morbidity in Asian populations.<h4>Methods</h4>We identified 1,003 cases of POF among 36,402 postmenopausal women who participated in the Shanghai Women's Health Study, a pop...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089597&type=printable |
| _version_ | 1826799134966808576 |
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| author | Xiaoyan Wu Hui Cai Asha Kallianpur Honglan Li Gong Yang Jing Gao Yong-Bing Xiang Bu-Tian Ji Yu-Tang Wei Zheng Xiao-Ou Shu |
| author_facet | Xiaoyan Wu Hui Cai Asha Kallianpur Honglan Li Gong Yang Jing Gao Yong-Bing Xiang Bu-Tian Ji Yu-Tang Wei Zheng Xiao-Ou Shu |
| author_sort | Xiaoyan Wu |
| collection | DOAJ |
| description | <h4>Objective</h4>To evaluate associations of premature ovarian failure (POF) with mortality and morbidity in Asian populations.<h4>Methods</h4>We identified 1,003 cases of POF among 36,402 postmenopausal women who participated in the Shanghai Women's Health Study, a population-based cohort study. Cox regression and logistic regression models were applied in data analysis.<h4>Results</h4>After adjustment for potential confounding factors, we found that POF increased the risk of total and cancer-specific mortality (HR (95%CIs): 1.29 (1.08-1.54) and 1.38 (1.05-1.81), respectively). POF was also associated with high prevalence of autoimmune disease (OR (95%CI): 1.56 (1.04-2.35)) but decreased incidence of breast cancer (OR (95%CI): 0.59 (0.38-0.91)). Similar results were observed when hormone replacement therapy users were excluded from the analysis. POF is associated with high waist-to-hip ratio.<h4>Conclusions</h4>Our results suggest that women with POF experience increased mortality and that these women may benefit from heightened surveillance and appropriate interventions. |
| first_indexed | 2024-12-22T02:31:54Z |
| format | Article |
| id | doaj.art-43d019d1989c44a291b237fa53cb5953 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2025-03-17T00:30:16Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-43d019d1989c44a291b237fa53cb59532025-02-21T05:35:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e8959710.1371/journal.pone.0089597Impact of premature ovarian failure on mortality and morbidity among Chinese women.Xiaoyan WuHui CaiAsha KallianpurHonglan LiGong YangJing GaoYong-Bing XiangBu-Tian JiYu-TangWei ZhengXiao-Ou Shu<h4>Objective</h4>To evaluate associations of premature ovarian failure (POF) with mortality and morbidity in Asian populations.<h4>Methods</h4>We identified 1,003 cases of POF among 36,402 postmenopausal women who participated in the Shanghai Women's Health Study, a population-based cohort study. Cox regression and logistic regression models were applied in data analysis.<h4>Results</h4>After adjustment for potential confounding factors, we found that POF increased the risk of total and cancer-specific mortality (HR (95%CIs): 1.29 (1.08-1.54) and 1.38 (1.05-1.81), respectively). POF was also associated with high prevalence of autoimmune disease (OR (95%CI): 1.56 (1.04-2.35)) but decreased incidence of breast cancer (OR (95%CI): 0.59 (0.38-0.91)). Similar results were observed when hormone replacement therapy users were excluded from the analysis. POF is associated with high waist-to-hip ratio.<h4>Conclusions</h4>Our results suggest that women with POF experience increased mortality and that these women may benefit from heightened surveillance and appropriate interventions.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089597&type=printable |
| spellingShingle | Xiaoyan Wu Hui Cai Asha Kallianpur Honglan Li Gong Yang Jing Gao Yong-Bing Xiang Bu-Tian Ji Yu-Tang Wei Zheng Xiao-Ou Shu Impact of premature ovarian failure on mortality and morbidity among Chinese women. PLoS ONE |
| title | Impact of premature ovarian failure on mortality and morbidity among Chinese women. |
| title_full | Impact of premature ovarian failure on mortality and morbidity among Chinese women. |
| title_fullStr | Impact of premature ovarian failure on mortality and morbidity among Chinese women. |
| title_full_unstemmed | Impact of premature ovarian failure on mortality and morbidity among Chinese women. |
| title_short | Impact of premature ovarian failure on mortality and morbidity among Chinese women. |
| title_sort | impact of premature ovarian failure on mortality and morbidity among chinese women |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0089597&type=printable |
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