World Health Organization Classification of Tumors of the Central Nervous System 5th Edition (WHO CNS5): What's new?
The latest fifth edition of the World Health Organization classification of central nervous system tumors (WHO CNS5) has been built on the prior WHO 2016 classification as well as recommendations put forward by seven updates of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=5;spage=5;epage=13;aulast=Mahajan |
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| author | Swati Mahajan Vaishali Suri Saumya Sahu Mehar C Sharma Chitra Sarkar |
| author_facet | Swati Mahajan Vaishali Suri Saumya Sahu Mehar C Sharma Chitra Sarkar |
| author_sort | Swati Mahajan |
| collection | DOAJ |
| description | The latest fifth edition of the World Health Organization classification of central nervous system tumors (WHO CNS5) has been built on the prior WHO 2016 classification as well as recommendations put forward by seven updates of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT). Various new tumor types and subtypes have been recognized which are of clinical significance. Tumor groups have been restructured and the nomenclature of some tumor types has also been revised. The use of terms 'entity' and 'variant' have been replaced by 'type' and 'subtype'. Significant changes have been introduced in the grading of tumors viz. use of Arabic numerals, grading within individual tumor types and combined histological and molecular grading. The terms 'Not otherwise specified' and 'Not elsewhere classified' can now be used for all tumor types. WHO CNS5 also for the first time endorses the use of DNA methylation profiling for the diagnosis of some tumor types/subtypes. Finally, the importance of combining histology with molecular parameters is emphasized for the “layered reporting” and “integrated diagnosis”, which will provide valuable diagnostic, prognostic, and predictive information, as well as for some entities, suggest targeted therapies. |
| first_indexed | 2024-12-12T13:39:02Z |
| format | Article |
| id | doaj.art-43d1823c27d140bfa804a13e970746f5 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-12T13:39:02Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-43d1823c27d140bfa804a13e970746f52022-12-22T00:22:51ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292022-01-0165551310.4103/ijpm.ijpm_48_22World Health Organization Classification of Tumors of the Central Nervous System 5th Edition (WHO CNS5): What's new?Swati MahajanVaishali SuriSaumya SahuMehar C SharmaChitra SarkarThe latest fifth edition of the World Health Organization classification of central nervous system tumors (WHO CNS5) has been built on the prior WHO 2016 classification as well as recommendations put forward by seven updates of the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT). Various new tumor types and subtypes have been recognized which are of clinical significance. Tumor groups have been restructured and the nomenclature of some tumor types has also been revised. The use of terms 'entity' and 'variant' have been replaced by 'type' and 'subtype'. Significant changes have been introduced in the grading of tumors viz. use of Arabic numerals, grading within individual tumor types and combined histological and molecular grading. The terms 'Not otherwise specified' and 'Not elsewhere classified' can now be used for all tumor types. WHO CNS5 also for the first time endorses the use of DNA methylation profiling for the diagnosis of some tumor types/subtypes. Finally, the importance of combining histology with molecular parameters is emphasized for the “layered reporting” and “integrated diagnosis”, which will provide valuable diagnostic, prognostic, and predictive information, as well as for some entities, suggest targeted therapies.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=5;spage=5;epage=13;aulast=Mahajan5th editioncnsupdateswho |
| spellingShingle | Swati Mahajan Vaishali Suri Saumya Sahu Mehar C Sharma Chitra Sarkar World Health Organization Classification of Tumors of the Central Nervous System 5th Edition (WHO CNS5): What's new? Indian Journal of Pathology and Microbiology 5th edition cns updates who |
| title | World Health Organization Classification of Tumors of the Central Nervous System 5th Edition (WHO CNS5): What's new? |
| title_full | World Health Organization Classification of Tumors of the Central Nervous System 5th Edition (WHO CNS5): What's new? |
| title_fullStr | World Health Organization Classification of Tumors of the Central Nervous System 5th Edition (WHO CNS5): What's new? |
| title_full_unstemmed | World Health Organization Classification of Tumors of the Central Nervous System 5th Edition (WHO CNS5): What's new? |
| title_short | World Health Organization Classification of Tumors of the Central Nervous System 5th Edition (WHO CNS5): What's new? |
| title_sort | world health organization classification of tumors of the central nervous system 5th edition who cns5 what s new |
| topic | 5th edition cns updates who |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=5;spage=5;epage=13;aulast=Mahajan |
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