Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all Suidae (Kemin Europa N.V)
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of endo‐1,4‐β‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) as a zootechnical feed additive (functional group: digestibility enhancers) for al...
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | EFSA Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.2903/j.efsa.2024.8579 |
| _version_ | 1797261633055096832 |
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| author | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Roberto Edoardo Villa Ruud Woutersen Noël Dierick Montserrat Anguita Jaume Galobart Matteo Lorenzo Innocenti Jordi Ortuño Jordi Tarres‐Call Joana P. Firmino |
| author_facet | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Roberto Edoardo Villa Ruud Woutersen Noël Dierick Montserrat Anguita Jaume Galobart Matteo Lorenzo Innocenti Jordi Ortuño Jordi Tarres‐Call Joana P. Firmino |
| author_sort | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
| collection | DOAJ |
| description | Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of endo‐1,4‐β‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) as a zootechnical feed additive (functional group: digestibility enhancers) for all Suidae at a recommended minimum level of 90,000 U/kg complete feed for pigs in the growing period and 45,000 U/kg complete feed for sows. The production strain is considered suitable for the qualified presumption of safety (QPS) approach to safety assessment. The FEEDAP Panel concluded that the additive is safe at the minimum recommended use level for all growing Suidae and all sows in the lactating phase. Xygest™ HT was considered safe for the consumers and for the environment when used in feed for all Suidae. The additive was considered not to be irritant to eyes and skin, but was considered as a dermal and respiratory sensitiser. In the absence of sufficient data, the FEEDAP Panel was not in the position to conclude on the efficacy of Xygest™ HT for all Suidae. |
| first_indexed | 2024-03-07T19:20:50Z |
| format | Article |
| id | doaj.art-43d1ef87aff94e5eae5869178daa2104 |
| institution | Directory Open Access Journal |
| issn | 1831-4732 |
| language | English |
| last_indexed | 2024-04-24T23:44:19Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj.art-43d1ef87aff94e5eae5869178daa21042024-03-15T08:30:36ZengWileyEFSA Journal1831-47322024-02-01222n/an/a10.2903/j.efsa.2024.8579Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all Suidae (Kemin Europa N.V)EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Vasileios BampidisGiovanna AzimontiMaria de Lourdes BastosHenrik ChristensenMojca DurjavaBirgit DusemundMaryline KoubaMarta López‐AlonsoSecundino López PuenteFrancesca MarconBaltasar MayoAlena PechováMariana PetkovaFernando RamosRoberto Edoardo VillaRuud WoutersenNoël DierickMontserrat AnguitaJaume GalobartMatteo Lorenzo InnocentiJordi OrtuñoJordi Tarres‐CallJoana P. FirminoAbstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of endo‐1,4‐β‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) as a zootechnical feed additive (functional group: digestibility enhancers) for all Suidae at a recommended minimum level of 90,000 U/kg complete feed for pigs in the growing period and 45,000 U/kg complete feed for sows. The production strain is considered suitable for the qualified presumption of safety (QPS) approach to safety assessment. The FEEDAP Panel concluded that the additive is safe at the minimum recommended use level for all growing Suidae and all sows in the lactating phase. Xygest™ HT was considered safe for the consumers and for the environment when used in feed for all Suidae. The additive was considered not to be irritant to eyes and skin, but was considered as a dermal and respiratory sensitiser. In the absence of sufficient data, the FEEDAP Panel was not in the position to conclude on the efficacy of Xygest™ HT for all Suidae.https://doi.org/10.2903/j.efsa.2024.8579digestibility enhancersefficacyKomagataella phaffii ATCC PTA 127053safetySuidaeXygest™ HT |
| spellingShingle | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Mojca Durjava Birgit Dusemund Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Roberto Edoardo Villa Ruud Woutersen Noël Dierick Montserrat Anguita Jaume Galobart Matteo Lorenzo Innocenti Jordi Ortuño Jordi Tarres‐Call Joana P. Firmino Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all Suidae (Kemin Europa N.V) EFSA Journal digestibility enhancers efficacy Komagataella phaffii ATCC PTA 127053 safety Suidae Xygest™ HT |
| title | Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all Suidae (Kemin Europa N.V) |
| title_full | Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all Suidae (Kemin Europa N.V) |
| title_fullStr | Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all Suidae (Kemin Europa N.V) |
| title_full_unstemmed | Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all Suidae (Kemin Europa N.V) |
| title_short | Safety and efficacy of a feed additive consisting of endo‐1,4‐β‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all Suidae (Kemin Europa N.V) |
| title_sort | safety and efficacy of a feed additive consisting of endo 1 4 β xylanase produced by komagataella phaffii atcc pta 127053 xygest™ ht for all suidae kemin europa n v |
| topic | digestibility enhancers efficacy Komagataella phaffii ATCC PTA 127053 safety Suidae Xygest™ HT |
| url | https://doi.org/10.2903/j.efsa.2024.8579 |
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