Use of probiotics in patients with chronic kidney disease on hemodialysis: a randomized clinical trial
ABSTRACT Introduction: Supplementation with probiotics for patients with chronic kidney disease (CKD) may be associated with decreased systemic inflammation. Objective: To assess the impact of oral supplementation with probiotics for patients with CKD on hemodialysis. Method: This double-blind ra...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Nefrologia
2022-09-01
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| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022005045403&tlng=pt |
| _version_ | 1818065186126299136 |
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| author | Érica Maria Rodrigues de Araújo Gdayllon Cavalcante Meneses Antônio Augusto Ferreira Carioca Alice Maria Costa Martins Elizabeth De Francesco Daher Geraldo Bezerra da Silva Junior |
| author_facet | Érica Maria Rodrigues de Araújo Gdayllon Cavalcante Meneses Antônio Augusto Ferreira Carioca Alice Maria Costa Martins Elizabeth De Francesco Daher Geraldo Bezerra da Silva Junior |
| author_sort | Érica Maria Rodrigues de Araújo |
| collection | DOAJ |
| description | ABSTRACT Introduction: Supplementation with probiotics for patients with chronic kidney disease (CKD) may be associated with decreased systemic inflammation. Objective: To assess the impact of oral supplementation with probiotics for patients with CKD on hemodialysis. Method: This double-blind randomized clinical trial included 70 patients on hemodialysis; 32 were given oral supplementation with probiotics and 38 were in the placebo group. Blood samples were collected at the start of the study and patients were given oral supplementation with probiotics or placebo for three months. The probiotic supplement comprised four strains of encapsulated Gram-positive bacteria: Lactobacillus Plantarum A87, Lactobacillus rhamnosus, Bifidobacterium bifidum A218 and Bifidobacterium longum A101. Patients were given one capsule per day for 3 months. Blood samples were taken throughout the study to check for inflammatory biomarkers. Non-traditional biomarkers Syndecan-1, IFN-y, NGAL, and cystatin C were measured using an ELISA kit, along with biochemical parameters CRP, calcium, phosphorus, potassium, PTH, GPT, hematocrit, hemoglobin, glucose, and urea. Results: Patients given supplementation with probiotics had significant decreases in serum levels of syndecan-1 (239 ± 113 to 184 ± 106 ng/mL, p = 0.005); blood glucose levels also decreased significantly (162 ± 112 to 146 ± 74 mg/dL, p = 0.02). Conclusion: Administration of probiotics to patients with advanced CKD was associated with decreases in syndecan-1 and blood glucose levels, indicating potential improvements in metabolism and decreased systemic inflammation. |
| first_indexed | 2024-12-10T14:47:53Z |
| format | Article |
| id | doaj.art-43d47d462a6c4e7895d0c42ed95f26af |
| institution | Directory Open Access Journal |
| issn | 2175-8239 |
| language | English |
| last_indexed | 2024-12-10T14:47:53Z |
| publishDate | 2022-09-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj.art-43d47d462a6c4e7895d0c42ed95f26af2022-12-22T01:44:31ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392022-09-0110.1590/2175-8239-jbn-2022-0021enUse of probiotics in patients with chronic kidney disease on hemodialysis: a randomized clinical trialÉrica Maria Rodrigues de Araújohttps://orcid.org/0000-0002-1686-5274Gdayllon Cavalcante Meneseshttps://orcid.org/0000-0002-0160-5728Antônio Augusto Ferreira Cariocahttps://orcid.org/0000-0002-1194-562XAlice Maria Costa Martinshttps://orcid.org/0000-0001-8160-2027Elizabeth De Francesco Daherhttps://orcid.org/0000-0003-4189-1738Geraldo Bezerra da Silva Juniorhttps://orcid.org/0000-0002-8971-0994ABSTRACT Introduction: Supplementation with probiotics for patients with chronic kidney disease (CKD) may be associated with decreased systemic inflammation. Objective: To assess the impact of oral supplementation with probiotics for patients with CKD on hemodialysis. Method: This double-blind randomized clinical trial included 70 patients on hemodialysis; 32 were given oral supplementation with probiotics and 38 were in the placebo group. Blood samples were collected at the start of the study and patients were given oral supplementation with probiotics or placebo for three months. The probiotic supplement comprised four strains of encapsulated Gram-positive bacteria: Lactobacillus Plantarum A87, Lactobacillus rhamnosus, Bifidobacterium bifidum A218 and Bifidobacterium longum A101. Patients were given one capsule per day for 3 months. Blood samples were taken throughout the study to check for inflammatory biomarkers. Non-traditional biomarkers Syndecan-1, IFN-y, NGAL, and cystatin C were measured using an ELISA kit, along with biochemical parameters CRP, calcium, phosphorus, potassium, PTH, GPT, hematocrit, hemoglobin, glucose, and urea. Results: Patients given supplementation with probiotics had significant decreases in serum levels of syndecan-1 (239 ± 113 to 184 ± 106 ng/mL, p = 0.005); blood glucose levels also decreased significantly (162 ± 112 to 146 ± 74 mg/dL, p = 0.02). Conclusion: Administration of probiotics to patients with advanced CKD was associated with decreases in syndecan-1 and blood glucose levels, indicating potential improvements in metabolism and decreased systemic inflammation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022005045403&tlng=ptRenal Insufficiency, ChronicProbioticsGastrointestinal MicrobiomeInflammationBiomarkers |
| spellingShingle | Érica Maria Rodrigues de Araújo Gdayllon Cavalcante Meneses Antônio Augusto Ferreira Carioca Alice Maria Costa Martins Elizabeth De Francesco Daher Geraldo Bezerra da Silva Junior Use of probiotics in patients with chronic kidney disease on hemodialysis: a randomized clinical trial Brazilian Journal of Nephrology Renal Insufficiency, Chronic Probiotics Gastrointestinal Microbiome Inflammation Biomarkers |
| title | Use of probiotics in patients with chronic kidney disease on hemodialysis: a randomized clinical trial |
| title_full | Use of probiotics in patients with chronic kidney disease on hemodialysis: a randomized clinical trial |
| title_fullStr | Use of probiotics in patients with chronic kidney disease on hemodialysis: a randomized clinical trial |
| title_full_unstemmed | Use of probiotics in patients with chronic kidney disease on hemodialysis: a randomized clinical trial |
| title_short | Use of probiotics in patients with chronic kidney disease on hemodialysis: a randomized clinical trial |
| title_sort | use of probiotics in patients with chronic kidney disease on hemodialysis a randomized clinical trial |
| topic | Renal Insufficiency, Chronic Probiotics Gastrointestinal Microbiome Inflammation Biomarkers |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002022005045403&tlng=pt |
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