Combinations of Hydrostatic Pressure and Shear Stress Time-dependently Decrease E-selectin, VCAM-1 and ICAM-1 Expression Induced by Tumor Necrosis Factor-Alpha in Cultured Endothelial Cells

Combinations of Hydrostatic Pressure and Shear Stress Time-dependently Decrease E-selectin, VCAM-1 and ICAM-1 Expression Induced by Tumor Necrosis Factor-Alpha in Cultured Endothelial Cells

Endothelial cells (ECs) are constantly subjected to shear stress, a tangential stress generated by blood flow, and hydrostatic pressure, a normal stress generated by blood pressure. Using a perfusion system that enables the independent control of flow volume and pressure, we investigated the effect...

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Bibliographic Details
Main Authors: Hiromichi NAKADATE, Eiichi SEKIZUKA, Shigeru AOMURA, Haruyuki MINAMITANI
Format: Article
Language:English
Published: The Japan Society of Mechanical Engineers 2012-03-01
Series:Journal of Biomechanical Science and Engineering
Subjects:
endothelial cells
hydrostatic pressure
shear stress
e-selectin
vcam-1
icam-1
tnf-α
immunofluorescence
Online Access:https://www.jstage.jst.go.jp/article/jbse/7/2/7_2_118/_pdf/-char/en

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