Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke

Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke

Abstract Background Ischemic stroke is a medical emergency that primarily affects the elderly. A complex immune response in the post-stroke brain constitutes a key component of stroke pathophysiology. This study aimed to determine how stroke affects immune cell populations in the aged brain based on...

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Bibliographic Details
Main Authors: Xuan Li, Jingjun Lyu, Ran Li, Vaibhav Jain, Yuntian Shen, Ángela del Águila, Ulrike Hoffmann, Huaxin Sheng, Wei Yang
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Transcriptome
scRNA-seq
Late reperfusion
Microglia
Neutrophil
Online Access:https://doi.org/10.1186/s12974-022-02447-5

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