Gene drives as a new quality in GMO releases—a comparative technology characterization
Compared to previous releases of genetically modified organisms (GMOs) which were primarily plants, gene drives represent a paradigm shift in the handling of GMOs: Current regulation of the release of GMOs assumes that for specific periods of time a certain amount of GMOs will be released in a parti...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2019-05-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/6793.pdf |
| _version_ | 1827608166577209344 |
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| author | Johannes L. Frieß Arnim von Gleich Bernd Giese |
| author_facet | Johannes L. Frieß Arnim von Gleich Bernd Giese |
| author_sort | Johannes L. Frieß |
| collection | DOAJ |
| description | Compared to previous releases of genetically modified organisms (GMOs) which were primarily plants, gene drives represent a paradigm shift in the handling of GMOs: Current regulation of the release of GMOs assumes that for specific periods of time a certain amount of GMOs will be released in a particular region. However, now a type of genetic technology arises whose innermost principle lies in exceeding these limits—the transformation or even eradication of wild populations. The invasive character of gene drives demands a thorough analysis of their functionalities, reliability and potential impact. But such investigations are hindered by the fact that an experimental field test would hardly be reversible. Therefore, an appropriate prospective assessment is of utmost importance for an estimation of the risk potential associated with the application of gene drives. This work is meant to support the inevitable characterization of gene drives by a comparative approach of prospective technology assessment with a focus on potential sources of risk. Therein, the hazard and exposure potential as well as uncertainties with regard to the performance of synthetic gene drives are addressed. Moreover, a quantitative analysis of their invasiveness should enable a differentiated evaluation of their power to transform wild populations. |
| first_indexed | 2024-03-09T07:06:09Z |
| format | Article |
| id | doaj.art-43d95b99804e4bb48c3939f4ab63108a |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:06:09Z |
| publishDate | 2019-05-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-43d95b99804e4bb48c3939f4ab63108a2023-12-03T09:30:06ZengPeerJ Inc.PeerJ2167-83592019-05-017e679310.7717/peerj.6793Gene drives as a new quality in GMO releases—a comparative technology characterizationJohannes L. Frieß0Arnim von Gleich1Bernd Giese2Institute for Safety/Security and Risk Sciences, University of Natural Resources and Life Sciences, Vienna (BOKU), AustriaDepartment of Technology Design and Development, Faculty of Production Engineering, University of Bremen, GermanyInstitute for Safety/Security and Risk Sciences, University of Natural Resources and Life Sciences, Vienna (BOKU), AustriaCompared to previous releases of genetically modified organisms (GMOs) which were primarily plants, gene drives represent a paradigm shift in the handling of GMOs: Current regulation of the release of GMOs assumes that for specific periods of time a certain amount of GMOs will be released in a particular region. However, now a type of genetic technology arises whose innermost principle lies in exceeding these limits—the transformation or even eradication of wild populations. The invasive character of gene drives demands a thorough analysis of their functionalities, reliability and potential impact. But such investigations are hindered by the fact that an experimental field test would hardly be reversible. Therefore, an appropriate prospective assessment is of utmost importance for an estimation of the risk potential associated with the application of gene drives. This work is meant to support the inevitable characterization of gene drives by a comparative approach of prospective technology assessment with a focus on potential sources of risk. Therein, the hazard and exposure potential as well as uncertainties with regard to the performance of synthetic gene drives are addressed. Moreover, a quantitative analysis of their invasiveness should enable a differentiated evaluation of their power to transform wild populations.https://peerj.com/articles/6793.pdfGene driveTechnology characterizationGMO releasesProspective technology assessmentExposureHazard |
| spellingShingle | Johannes L. Frieß Arnim von Gleich Bernd Giese Gene drives as a new quality in GMO releases—a comparative technology characterization PeerJ Gene drive Technology characterization GMO releases Prospective technology assessment Exposure Hazard |
| title | Gene drives as a new quality in GMO releases—a comparative technology characterization |
| title_full | Gene drives as a new quality in GMO releases—a comparative technology characterization |
| title_fullStr | Gene drives as a new quality in GMO releases—a comparative technology characterization |
| title_full_unstemmed | Gene drives as a new quality in GMO releases—a comparative technology characterization |
| title_short | Gene drives as a new quality in GMO releases—a comparative technology characterization |
| title_sort | gene drives as a new quality in gmo releases a comparative technology characterization |
| topic | Gene drive Technology characterization GMO releases Prospective technology assessment Exposure Hazard |
| url | https://peerj.com/articles/6793.pdf |
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