Body height in young adult men and risk of dementia later in adult life
This study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939–1959 and examined at the conscript board...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-02-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/51168 |
| _version_ | 1811199505325883392 |
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| author | Terese Sara Høj Jørgensen Gunhild Tidemann Okholm Kaare Christensen Thorkild IA Sørensen Merere Osler |
| author_facet | Terese Sara Høj Jørgensen Gunhild Tidemann Okholm Kaare Christensen Thorkild IA Sørensen Merere Osler |
| author_sort | Terese Sara Høj Jørgensen |
| collection | DOAJ |
| description | This study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939–1959 and examined at the conscript board were followed in Danish nationwide registers (1969–2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial factors including partly shared genetics. In total, 10,599 men were diagnosed with dementia. The association between one z-score difference in body height and dementia (HR: 0.90, 95% CI: 0.89;0.90) was inverse and weakened slightly after adjustment for intelligence test scores and educational level. The associations persisted in within-brother analysis and revealed a stronger, but less precise, point estimate than the cohort analysis of brothers. The twin analysis showed similar, but imprecise estimates. |
| first_indexed | 2024-04-12T01:49:14Z |
| format | Article |
| id | doaj.art-43dc85f3acfc4c20b8c2af939cf008db |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:49:14Z |
| publishDate | 2020-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-43dc85f3acfc4c20b8c2af939cf008db2022-12-22T03:52:58ZengeLife Sciences Publications LtdeLife2050-084X2020-02-01910.7554/eLife.51168Body height in young adult men and risk of dementia later in adult lifeTerese Sara Høj Jørgensen0https://orcid.org/0000-0003-1450-4472Gunhild Tidemann Okholm1Kaare Christensen2Thorkild IA Sørensen3https://orcid.org/0000-0003-4821-430XMerere Osler4https://orcid.org/0000-0002-6921-220XCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDanish Aging Research Center, Department of Public Health, University of Southern Denmark, Copenhagen, DenmarkDepartment of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkThis study examined the relationship between body height and dementia and explored the impact of intelligence level, educational attainment, early life environment and familial factors. A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939–1959 and examined at the conscript board were followed in Danish nationwide registers (1969–2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial factors including partly shared genetics. In total, 10,599 men were diagnosed with dementia. The association between one z-score difference in body height and dementia (HR: 0.90, 95% CI: 0.89;0.90) was inverse and weakened slightly after adjustment for intelligence test scores and educational level. The associations persisted in within-brother analysis and revealed a stronger, but less precise, point estimate than the cohort analysis of brothers. The twin analysis showed similar, but imprecise estimates.https://elifesciences.org/articles/51168dementiabody heightcognitive reservecohort studysibling design |
| spellingShingle | Terese Sara Høj Jørgensen Gunhild Tidemann Okholm Kaare Christensen Thorkild IA Sørensen Merere Osler Body height in young adult men and risk of dementia later in adult life eLife dementia body height cognitive reserve cohort study sibling design |
| title | Body height in young adult men and risk of dementia later in adult life |
| title_full | Body height in young adult men and risk of dementia later in adult life |
| title_fullStr | Body height in young adult men and risk of dementia later in adult life |
| title_full_unstemmed | Body height in young adult men and risk of dementia later in adult life |
| title_short | Body height in young adult men and risk of dementia later in adult life |
| title_sort | body height in young adult men and risk of dementia later in adult life |
| topic | dementia body height cognitive reserve cohort study sibling design |
| url | https://elifesciences.org/articles/51168 |
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