Autocrine prostaglandin E2 signaling promotes tumor cell survival and proliferation in childhood neuroblastoma.
BACKGROUND: Prostaglandin E(2) (PGE(2)) is an important mediator in tumor-promoting inflammation. High expression of cyclooxygenase-2 (COX-2) has been detected in the embryonic childhood tumor neuroblastoma, and treatment with COX inhibitors significantly reduces tumor growth. Here, we have investig...
Main Authors: | Agnes Rasmuson, Anna Kock, Ole Martin Fuskevåg, Björn Kruspig, Jaione Simón-Santamaría, Vladimir Gogvadze, John Inge Johnsen, Per Kogner, Baldur Sveinbjörnsson |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3261878?pdf=render |
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