HIF1α-dependent hypoxia response in myeloid cells requires IRE1α

HIF1α-dependent hypoxia response in myeloid cells requires IRE1α

Abstract Cellular adaptation to low oxygen tension triggers primitive pathways that ensure proper cell function. Conditions of hypoxia and low glucose are characteristic of injured tissues and hence successive waves of inflammatory cells must be suited to function under low oxygen tension and metabo...

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Bibliographic Details
Main Authors: Gaëlle Mawambo, Malika Oubaha, Yusuke Ichiyama, Guillaume Blot, Sergio Crespo-Garcia, Agnieszka Dejda, François Binet, Roberto Diaz-Marin, Christina Sawchyn, Mikhail Sergeev, Rachel Juneau, Randal J. Kaufman, El Bachir Affar, Frédérick A. Mallette, Ariel M. Wilson, Przemyslaw Sapieha
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Neuroinflammation
Subjects:
HIF1α
Retina
Angiogenesis
Inflammation
IRE1α
Myeloid
Online Access:https://doi.org/10.1186/s12974-023-02793-y

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