Therapeutic Advancements in Metal and Metal Oxide Nanoparticle-Based Radiosensitization for Head and Neck Cancer Therapy
Although radiation therapy (RT) is one of the mainstays of head and neck cancer (HNC) treatment, innovative approaches are needed to further improve treatment outcomes. A significant challenge has been to design delivery strategies that focus high doses of radiation on the tumor tissue while minimiz...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/3/514 |
| _version_ | 1797488838542622720 |
|---|---|
| author | Poornima Dubey Mathieu Sertorio Vinita Takiar |
| author_facet | Poornima Dubey Mathieu Sertorio Vinita Takiar |
| author_sort | Poornima Dubey |
| collection | DOAJ |
| description | Although radiation therapy (RT) is one of the mainstays of head and neck cancer (HNC) treatment, innovative approaches are needed to further improve treatment outcomes. A significant challenge has been to design delivery strategies that focus high doses of radiation on the tumor tissue while minimizing damage to surrounding structures. In the last decade, there has been increasing interest in harnessing high atomic number materials (Z-elements) as nanoparticle radiosensitizers that can also be specifically directed to the tumor bed. Metallic nanoparticles typically display chemical inertness in cellular and subcellular systems but serve as significant radioenhancers for synergistic tumor cell killing in the presence of ionizing radiation. In this review, we discuss the current research and therapeutic efficacy of metal nanoparticle (MNP)-based radiosensitizers, specifically in the treatment of HNC with an emphasis on gold- (AuNPs), gadolinium- (AGdIX), and silver- (Ag) based nanoparticles together with the metallic oxide-based hafnium (Hf), zinc (ZnO) and iron (SPION) nanoparticles. Both in vitro and in vivo systems for different ionizing radiations including photons and protons were reviewed. Finally, the current status of preclinical and clinical studies using MNP-enhanced radiation therapy is discussed. |
| first_indexed | 2024-03-10T00:08:00Z |
| format | Article |
| id | doaj.art-43e4ea2393f44d2a93dfc88e540f28c7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:08:00Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-43e4ea2393f44d2a93dfc88e540f28c72023-11-23T16:04:05ZengMDPI AGCancers2072-66942022-01-0114351410.3390/cancers14030514Therapeutic Advancements in Metal and Metal Oxide Nanoparticle-Based Radiosensitization for Head and Neck Cancer TherapyPoornima Dubey0Mathieu Sertorio1Vinita Takiar2Department of Radiation Oncology, University of Cincinnati Barrett Cancer Center, 234 Goodman Street, ML 0757, Cincinnati, OH 45267, USADepartment of Radiation Oncology, University of Cincinnati Barrett Cancer Center, 234 Goodman Street, ML 0757, Cincinnati, OH 45267, USADepartment of Radiation Oncology, University of Cincinnati Barrett Cancer Center, 234 Goodman Street, ML 0757, Cincinnati, OH 45267, USAAlthough radiation therapy (RT) is one of the mainstays of head and neck cancer (HNC) treatment, innovative approaches are needed to further improve treatment outcomes. A significant challenge has been to design delivery strategies that focus high doses of radiation on the tumor tissue while minimizing damage to surrounding structures. In the last decade, there has been increasing interest in harnessing high atomic number materials (Z-elements) as nanoparticle radiosensitizers that can also be specifically directed to the tumor bed. Metallic nanoparticles typically display chemical inertness in cellular and subcellular systems but serve as significant radioenhancers for synergistic tumor cell killing in the presence of ionizing radiation. In this review, we discuss the current research and therapeutic efficacy of metal nanoparticle (MNP)-based radiosensitizers, specifically in the treatment of HNC with an emphasis on gold- (AuNPs), gadolinium- (AGdIX), and silver- (Ag) based nanoparticles together with the metallic oxide-based hafnium (Hf), zinc (ZnO) and iron (SPION) nanoparticles. Both in vitro and in vivo systems for different ionizing radiations including photons and protons were reviewed. Finally, the current status of preclinical and clinical studies using MNP-enhanced radiation therapy is discussed.https://www.mdpi.com/2072-6694/14/3/514head and neck cancer (HNC)radiosensitizermetal nanoparticle (MNP)metal oxide nanoparticleclinical translationnanoparticles |
| spellingShingle | Poornima Dubey Mathieu Sertorio Vinita Takiar Therapeutic Advancements in Metal and Metal Oxide Nanoparticle-Based Radiosensitization for Head and Neck Cancer Therapy Cancers head and neck cancer (HNC) radiosensitizer metal nanoparticle (MNP) metal oxide nanoparticle clinical translation nanoparticles |
| title | Therapeutic Advancements in Metal and Metal Oxide Nanoparticle-Based Radiosensitization for Head and Neck Cancer Therapy |
| title_full | Therapeutic Advancements in Metal and Metal Oxide Nanoparticle-Based Radiosensitization for Head and Neck Cancer Therapy |
| title_fullStr | Therapeutic Advancements in Metal and Metal Oxide Nanoparticle-Based Radiosensitization for Head and Neck Cancer Therapy |
| title_full_unstemmed | Therapeutic Advancements in Metal and Metal Oxide Nanoparticle-Based Radiosensitization for Head and Neck Cancer Therapy |
| title_short | Therapeutic Advancements in Metal and Metal Oxide Nanoparticle-Based Radiosensitization for Head and Neck Cancer Therapy |
| title_sort | therapeutic advancements in metal and metal oxide nanoparticle based radiosensitization for head and neck cancer therapy |
| topic | head and neck cancer (HNC) radiosensitizer metal nanoparticle (MNP) metal oxide nanoparticle clinical translation nanoparticles |
| url | https://www.mdpi.com/2072-6694/14/3/514 |
| work_keys_str_mv | AT poornimadubey therapeuticadvancementsinmetalandmetaloxidenanoparticlebasedradiosensitizationforheadandneckcancertherapy AT mathieusertorio therapeuticadvancementsinmetalandmetaloxidenanoparticlebasedradiosensitizationforheadandneckcancertherapy AT vinitatakiar therapeuticadvancementsinmetalandmetaloxidenanoparticlebasedradiosensitizationforheadandneckcancertherapy |