DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer
Free circulating DNA, which is thought to be derived from the primary tumour, can be detected in the blood of patients with cancer. Detection of genetic and epigenetic alteration in this tumour DNA offers a potential source of development of prognostic and predictive biomarkers for cancer. One such...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2007-01-01
|
| Series: | Biomarker Insights |
| Subjects: | |
| Online Access: | http://la-press.com/article.php?article_id=500 |
| _version_ | 1818281621539782656 |
|---|---|
| author | Ruth E Board Lucy Knight Alastair Greystoke Fiona H Blackhall Andrew Hughes Caroline Dive5 Malcolm Ranson |
| author_facet | Ruth E Board Lucy Knight Alastair Greystoke Fiona H Blackhall Andrew Hughes Caroline Dive5 Malcolm Ranson |
| author_sort | Ruth E Board |
| collection | DOAJ |
| description | Free circulating DNA, which is thought to be derived from the primary tumour, can be detected in the blood of patients with cancer. Detection of genetic and epigenetic alteration in this tumour DNA offers a potential source of development of prognostic and predictive biomarkers for cancer. One such change is DNA methylation of the promotor region of tumour suppressor genes. This causes down regulation of tumour suppressor gene expression, a frequent event in carcinogenesis. Hypermethylation of the promotor region of a number of genes has been detected in many tumour types and more recently these changes have been detected in circulating tumour DNA. This review will summarise the literature detailing DNA methylation in circulating tumour DNA and discuss some of the current controversies and technical challenges facing its use as a potential biomarker for cancer. |
| first_indexed | 2024-12-13T00:08:02Z |
| format | Article |
| id | doaj.art-43e5b1fa303248ce8d8c0400ab51d17e |
| institution | Directory Open Access Journal |
| issn | 1177-2719 |
| language | English |
| last_indexed | 2024-12-13T00:08:02Z |
| publishDate | 2007-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Biomarker Insights |
| spelling | doaj.art-43e5b1fa303248ce8d8c0400ab51d17e2022-12-22T00:06:07ZengSAGE PublishingBiomarker Insights1177-27192007-01-012307319DNA Methylation in Circulating Tumour DNA as a Biomarker for CancerRuth E BoardLucy KnightAlastair GreystokeFiona H BlackhallAndrew HughesCaroline Dive5Malcolm RansonFree circulating DNA, which is thought to be derived from the primary tumour, can be detected in the blood of patients with cancer. Detection of genetic and epigenetic alteration in this tumour DNA offers a potential source of development of prognostic and predictive biomarkers for cancer. One such change is DNA methylation of the promotor region of tumour suppressor genes. This causes down regulation of tumour suppressor gene expression, a frequent event in carcinogenesis. Hypermethylation of the promotor region of a number of genes has been detected in many tumour types and more recently these changes have been detected in circulating tumour DNA. This review will summarise the literature detailing DNA methylation in circulating tumour DNA and discuss some of the current controversies and technical challenges facing its use as a potential biomarker for cancer.http://la-press.com/article.php?article_id=500DNA methylationbiomarkercirculating tumour DNAMSPMethyLight |
| spellingShingle | Ruth E Board Lucy Knight Alastair Greystoke Fiona H Blackhall Andrew Hughes Caroline Dive5 Malcolm Ranson DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer Biomarker Insights DNA methylation biomarker circulating tumour DNA MSP MethyLight |
| title | DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer |
| title_full | DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer |
| title_fullStr | DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer |
| title_full_unstemmed | DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer |
| title_short | DNA Methylation in Circulating Tumour DNA as a Biomarker for Cancer |
| title_sort | dna methylation in circulating tumour dna as a biomarker for cancer |
| topic | DNA methylation biomarker circulating tumour DNA MSP MethyLight |
| url | http://la-press.com/article.php?article_id=500 |
| work_keys_str_mv | AT rutheboard dnamethylationincirculatingtumourdnaasabiomarkerforcancer AT lucyknight dnamethylationincirculatingtumourdnaasabiomarkerforcancer AT alastairgreystoke dnamethylationincirculatingtumourdnaasabiomarkerforcancer AT fionahblackhall dnamethylationincirculatingtumourdnaasabiomarkerforcancer AT andrewhughes dnamethylationincirculatingtumourdnaasabiomarkerforcancer AT carolinedive5 dnamethylationincirculatingtumourdnaasabiomarkerforcancer AT malcolmranson dnamethylationincirculatingtumourdnaasabiomarkerforcancer |