Variation in mouse chemical signals is genetically controlled and environmentally modulated
Abstract In most mammals and particularly in mice, chemical communication relies on the detection of ethologically relevant fitness-related cues from other individuals. In mice, urine is the primary source of these signals, so we employed proteomics and metabolomics to identify key components of che...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-35450-8 |
| _version_ | 1827939962849329152 |
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| author | Romana Stopková Tereza Matějková Alica Dodoková Pavel Talacko Petr Zacek Radislav Sedlacek Jaroslav Piálek Pavel Stopka |
| author_facet | Romana Stopková Tereza Matějková Alica Dodoková Pavel Talacko Petr Zacek Radislav Sedlacek Jaroslav Piálek Pavel Stopka |
| author_sort | Romana Stopková |
| collection | DOAJ |
| description | Abstract In most mammals and particularly in mice, chemical communication relies on the detection of ethologically relevant fitness-related cues from other individuals. In mice, urine is the primary source of these signals, so we employed proteomics and metabolomics to identify key components of chemical signalling. We show that there is a correspondence between urinary volatiles and proteins in the representation of genetic background, sex and environment in two house mouse subspecies Mus musculus musculus and M. m. domesticus. We found that environment has a strong influence upon proteomic and metabolomic variation and that volatile mixtures better represent males while females have surprisingly more sex-biased proteins. Using machine learning and combined-omics techniques, we identified mixtures of metabolites and proteins that are associated with biological features. |
| first_indexed | 2024-03-13T09:02:29Z |
| format | Article |
| id | doaj.art-43e690c8fb874a0ca6bd05e5bae5f715 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T09:02:29Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-43e690c8fb874a0ca6bd05e5bae5f7152023-05-28T11:14:02ZengNature PortfolioScientific Reports2045-23222023-05-0113111310.1038/s41598-023-35450-8Variation in mouse chemical signals is genetically controlled and environmentally modulatedRomana Stopková0Tereza Matějková1Alica Dodoková2Pavel Talacko3Petr Zacek4Radislav Sedlacek5Jaroslav Piálek6Pavel Stopka7Department of Zoology, Faculty of Science, BIOCEV, Charles UniversityDepartment of Zoology, Faculty of Science, BIOCEV, Charles UniversityDepartment of Zoology, Faculty of Science, BIOCEV, Charles UniversityDepartment of Zoology, Faculty of Science, BIOCEV, Charles UniversityDepartment of Zoology, Faculty of Science, BIOCEV, Charles UniversityCzech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of SciencesResearch Facility Studenec, Institute of Vertebrate Biology, Czech Academy of SciencesDepartment of Zoology, Faculty of Science, BIOCEV, Charles UniversityAbstract In most mammals and particularly in mice, chemical communication relies on the detection of ethologically relevant fitness-related cues from other individuals. In mice, urine is the primary source of these signals, so we employed proteomics and metabolomics to identify key components of chemical signalling. We show that there is a correspondence between urinary volatiles and proteins in the representation of genetic background, sex and environment in two house mouse subspecies Mus musculus musculus and M. m. domesticus. We found that environment has a strong influence upon proteomic and metabolomic variation and that volatile mixtures better represent males while females have surprisingly more sex-biased proteins. Using machine learning and combined-omics techniques, we identified mixtures of metabolites and proteins that are associated with biological features.https://doi.org/10.1038/s41598-023-35450-8 |
| spellingShingle | Romana Stopková Tereza Matějková Alica Dodoková Pavel Talacko Petr Zacek Radislav Sedlacek Jaroslav Piálek Pavel Stopka Variation in mouse chemical signals is genetically controlled and environmentally modulated Scientific Reports |
| title | Variation in mouse chemical signals is genetically controlled and environmentally modulated |
| title_full | Variation in mouse chemical signals is genetically controlled and environmentally modulated |
| title_fullStr | Variation in mouse chemical signals is genetically controlled and environmentally modulated |
| title_full_unstemmed | Variation in mouse chemical signals is genetically controlled and environmentally modulated |
| title_short | Variation in mouse chemical signals is genetically controlled and environmentally modulated |
| title_sort | variation in mouse chemical signals is genetically controlled and environmentally modulated |
| url | https://doi.org/10.1038/s41598-023-35450-8 |
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