Effectiveness of tacrolimus ointment for dupilumab‐resistant facial erythema
Abstract Some patients treated with dupilumab for atopic dermatitis (AD) develop resistance on their face, despite achieving good response on other body parts. The pathomechanisms of dupilumab‐resistant facial erythema (DRFE) are unclear and its treatment is challenging. We report a case of DRFE res...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-12-01
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| Series: | JEADV Clinical Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jvc2.70 |
| _version_ | 1811213488785195008 |
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| author | Takeshi Fukumoto Chikako Nishigori |
| author_facet | Takeshi Fukumoto Chikako Nishigori |
| author_sort | Takeshi Fukumoto |
| collection | DOAJ |
| description | Abstract Some patients treated with dupilumab for atopic dermatitis (AD) develop resistance on their face, despite achieving good response on other body parts. The pathomechanisms of dupilumab‐resistant facial erythema (DRFE) are unclear and its treatment is challenging. We report a case of DRFE resistant to topical corticosteroids and delgocitinib that was successfully treated with tacrolimus ointment. Tacrolimus ointment was not effective for his facial AD before dupilumab initiation but was effective for DRFE, suggesting that DRFE has a different pathomechanism from AD. |
| first_indexed | 2024-04-12T05:47:37Z |
| format | Article |
| id | doaj.art-43e7809bc6cf4c3a9924bb6234e0395d |
| institution | Directory Open Access Journal |
| issn | 2768-6566 |
| language | English |
| last_indexed | 2024-04-12T05:47:37Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | JEADV Clinical Practice |
| spelling | doaj.art-43e7809bc6cf4c3a9924bb6234e0395d2022-12-22T03:45:24ZengWileyJEADV Clinical Practice2768-65662022-12-011442742910.1002/jvc2.70Effectiveness of tacrolimus ointment for dupilumab‐resistant facial erythemaTakeshi Fukumoto0Chikako Nishigori1Division of Dermatology, Department of Internal Related Kobe University Graduate School of Medicine Kobe JapanDivision of Dermatology, Department of Internal Related Kobe University Graduate School of Medicine Kobe JapanAbstract Some patients treated with dupilumab for atopic dermatitis (AD) develop resistance on their face, despite achieving good response on other body parts. The pathomechanisms of dupilumab‐resistant facial erythema (DRFE) are unclear and its treatment is challenging. We report a case of DRFE resistant to topical corticosteroids and delgocitinib that was successfully treated with tacrolimus ointment. Tacrolimus ointment was not effective for his facial AD before dupilumab initiation but was effective for DRFE, suggesting that DRFE has a different pathomechanism from AD.https://doi.org/10.1002/jvc2.70dermoscopydupilumabdupilumab‐resistant facial erythemaMalasseziatacrolimus ointment |
| spellingShingle | Takeshi Fukumoto Chikako Nishigori Effectiveness of tacrolimus ointment for dupilumab‐resistant facial erythema JEADV Clinical Practice dermoscopy dupilumab dupilumab‐resistant facial erythema Malassezia tacrolimus ointment |
| title | Effectiveness of tacrolimus ointment for dupilumab‐resistant facial erythema |
| title_full | Effectiveness of tacrolimus ointment for dupilumab‐resistant facial erythema |
| title_fullStr | Effectiveness of tacrolimus ointment for dupilumab‐resistant facial erythema |
| title_full_unstemmed | Effectiveness of tacrolimus ointment for dupilumab‐resistant facial erythema |
| title_short | Effectiveness of tacrolimus ointment for dupilumab‐resistant facial erythema |
| title_sort | effectiveness of tacrolimus ointment for dupilumab resistant facial erythema |
| topic | dermoscopy dupilumab dupilumab‐resistant facial erythema Malassezia tacrolimus ointment |
| url | https://doi.org/10.1002/jvc2.70 |
| work_keys_str_mv | AT takeshifukumoto effectivenessoftacrolimusointmentfordupilumabresistantfacialerythema AT chikakonishigori effectivenessoftacrolimusointmentfordupilumabresistantfacialerythema |