Application of Mesenchymal Stem Cells During Machine Perfusion: An Emerging Novel Strategy for Organ Preservation
Although solid organ transplantation remains the definitive management for patients with end-stage organ failure, this ultimate treatment has been limited by the number of acceptable donor organs. Therefore, efforts have been made to expand the donor pool by utilizing marginal organs from donation a...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-12-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.713920/full |
| _version_ | 1819103329539588096 |
|---|---|
| author | Jiale Li Qinbao Peng Ronghua Yang Kunsheng Li Peng Zhu Yufeng Zhu Pengyu Zhou Gábor Szabó Gábor Szabó Shaoyi Zheng |
| author_facet | Jiale Li Qinbao Peng Ronghua Yang Kunsheng Li Peng Zhu Yufeng Zhu Pengyu Zhou Gábor Szabó Gábor Szabó Shaoyi Zheng |
| author_sort | Jiale Li |
| collection | DOAJ |
| description | Although solid organ transplantation remains the definitive management for patients with end-stage organ failure, this ultimate treatment has been limited by the number of acceptable donor organs. Therefore, efforts have been made to expand the donor pool by utilizing marginal organs from donation after circulatory death or extended criteria donors. However, marginal organs are susceptible to ischemia-reperfusion injury (IRI) and entail higher requirements for organ preservation. Recently, machine perfusion has emerged as a novel preservation strategy for marginal grafts. This technique continually perfuses the organs to mimic the physiologic condition, allows the evaluation of pretransplant graft function, and more excitingly facilitates organ reconditioning during perfusion with pharmacological, gene, and stem cell therapy. As mesenchymal stem cells (MSCs) have anti-oxidative, immunomodulatory, and regenerative properties, mounting studies have demonstrated the therapeutic effects of MSCs on organ IRI and solid organ transplantation. Therefore, MSCs are promising candidates for organ reconditioning during machine perfusion. This review provides an overview of the application of MSCs combined with machine perfusion for lung, kidney, liver, and heart preservation and reconditioning. Promising preclinical results highlight the potential clinical translation of this innovative strategy to improve the quality of marginal grafts. |
| first_indexed | 2024-12-22T01:48:44Z |
| format | Article |
| id | doaj.art-43f07b504e3045bc8875c31d8ba97a2f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T01:48:44Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-43f07b504e3045bc8875c31d8ba97a2f2022-12-21T18:42:59ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-12-011210.3389/fimmu.2021.713920713920Application of Mesenchymal Stem Cells During Machine Perfusion: An Emerging Novel Strategy for Organ PreservationJiale Li0Qinbao Peng1Ronghua Yang2Kunsheng Li3Peng Zhu4Yufeng Zhu5Pengyu Zhou6Gábor Szabó7Gábor Szabó8Shaoyi Zheng9Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Burn Surgery and Skin Regeneration, The First People’s Hospital of Foshan, Foshan, ChinaDepartment of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, ChinaDepartment of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaLaboratory Animal Research Center, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, GermanyDepartment of Cardiac Surgery, University Hospital Halle (Saale), Halle, GermanyDepartment of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaAlthough solid organ transplantation remains the definitive management for patients with end-stage organ failure, this ultimate treatment has been limited by the number of acceptable donor organs. Therefore, efforts have been made to expand the donor pool by utilizing marginal organs from donation after circulatory death or extended criteria donors. However, marginal organs are susceptible to ischemia-reperfusion injury (IRI) and entail higher requirements for organ preservation. Recently, machine perfusion has emerged as a novel preservation strategy for marginal grafts. This technique continually perfuses the organs to mimic the physiologic condition, allows the evaluation of pretransplant graft function, and more excitingly facilitates organ reconditioning during perfusion with pharmacological, gene, and stem cell therapy. As mesenchymal stem cells (MSCs) have anti-oxidative, immunomodulatory, and regenerative properties, mounting studies have demonstrated the therapeutic effects of MSCs on organ IRI and solid organ transplantation. Therefore, MSCs are promising candidates for organ reconditioning during machine perfusion. This review provides an overview of the application of MSCs combined with machine perfusion for lung, kidney, liver, and heart preservation and reconditioning. Promising preclinical results highlight the potential clinical translation of this innovative strategy to improve the quality of marginal grafts.https://www.frontiersin.org/articles/10.3389/fimmu.2021.713920/fullmesenchymal stem cellsmachine perfusionischemia-reperfusion injuryorgan preservationtransplantation |
| spellingShingle | Jiale Li Qinbao Peng Ronghua Yang Kunsheng Li Peng Zhu Yufeng Zhu Pengyu Zhou Gábor Szabó Gábor Szabó Shaoyi Zheng Application of Mesenchymal Stem Cells During Machine Perfusion: An Emerging Novel Strategy for Organ Preservation Frontiers in Immunology mesenchymal stem cells machine perfusion ischemia-reperfusion injury organ preservation transplantation |
| title | Application of Mesenchymal Stem Cells During Machine Perfusion: An Emerging Novel Strategy for Organ Preservation |
| title_full | Application of Mesenchymal Stem Cells During Machine Perfusion: An Emerging Novel Strategy for Organ Preservation |
| title_fullStr | Application of Mesenchymal Stem Cells During Machine Perfusion: An Emerging Novel Strategy for Organ Preservation |
| title_full_unstemmed | Application of Mesenchymal Stem Cells During Machine Perfusion: An Emerging Novel Strategy for Organ Preservation |
| title_short | Application of Mesenchymal Stem Cells During Machine Perfusion: An Emerging Novel Strategy for Organ Preservation |
| title_sort | application of mesenchymal stem cells during machine perfusion an emerging novel strategy for organ preservation |
| topic | mesenchymal stem cells machine perfusion ischemia-reperfusion injury organ preservation transplantation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.713920/full |
| work_keys_str_mv | AT jialeli applicationofmesenchymalstemcellsduringmachineperfusionanemergingnovelstrategyfororganpreservation AT qinbaopeng applicationofmesenchymalstemcellsduringmachineperfusionanemergingnovelstrategyfororganpreservation AT ronghuayang applicationofmesenchymalstemcellsduringmachineperfusionanemergingnovelstrategyfororganpreservation AT kunshengli applicationofmesenchymalstemcellsduringmachineperfusionanemergingnovelstrategyfororganpreservation AT pengzhu applicationofmesenchymalstemcellsduringmachineperfusionanemergingnovelstrategyfororganpreservation AT yufengzhu applicationofmesenchymalstemcellsduringmachineperfusionanemergingnovelstrategyfororganpreservation AT pengyuzhou applicationofmesenchymalstemcellsduringmachineperfusionanemergingnovelstrategyfororganpreservation AT gaborszabo applicationofmesenchymalstemcellsduringmachineperfusionanemergingnovelstrategyfororganpreservation AT gaborszabo applicationofmesenchymalstemcellsduringmachineperfusionanemergingnovelstrategyfororganpreservation AT shaoyizheng applicationofmesenchymalstemcellsduringmachineperfusionanemergingnovelstrategyfororganpreservation |