Astrocytes: The Stars in Neurodegeneration?

Astrocytes: The Stars in Neurodegeneration?

Today, neurodegenerative disorders like Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) affect millions of people worldwide, and as the average human lifespan increases, similarly grows the number of patients. For many decades...

Full description

Bibliographic Details
Main Authors:	Katarina Stoklund Dittlau, Kristine Freude
Format:	Article
Language:	English
Published:	MDPI AG 2024-02-01
Series:	Biomolecules
Subjects:	astrocyte neurodegeneration reactivity non-cell autonomous cell autonomous cross-disease
Online Access:	https://www.mdpi.com/2218-273X/14/3/289

Similar Items

Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons
by: Y. X. Li, et al.
Published: (2018-09-01)

The Many Faces of Astrocytes in Alzheimer's Disease
by: Michael D. Monterey, et al.
Published: (2021-08-01)

Beta-Secretase 1 Underlies Reactive Astrocytes and Endothelial Disruption in Neurodegeneration
by: María Victoria Chacón-Quintero, et al.
Published: (2021-05-01)

Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective
by: Patrycja Mulica, et al.
Published: (2021-05-01)

Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons
by: Fabiola Rojas, et al.
Published: (2023-07-01)

Astrocytes in Neurodegeneration: Inspiration From Genetics
by: Jingxuan Huang, et al.
Published: (2022-06-01)

Why should we care about astrocytes in a motor neuron disease?
by: Katarina Stoklund Dittlau, et al.
Published: (2023-01-01)

Astrocytes in stroke-induced neurodegeneration: a timeline
by: Eileen Collyer, et al.
Published: (2023-09-01)

Roles of neuropathology-associated reactive astrocytes: a systematic review
by: Jill M. Lawrence, et al.
Published: (2023-03-01)

The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease
by: Aurelie de Rus Jacquet, et al.
Published: (2021-09-01)

FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms
by: Katarina Stoklund Dittlau, et al.
Published: (2023-01-01)

Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration
by: Rene Solano Fonseca, et al.
Published: (2021-09-01)

Cholesterol Dysmetabolism in Alzheimer’s Disease: A Starring Role for Astrocytes?
by: Erica Staurenghi, et al.
Published: (2021-11-01)

The Complement System: A Powerful Modulator and Effector of Astrocyte Function in the Healthy and Diseased Central Nervous System
by: Marcela Pekna, et al.
Published: (2021-07-01)

Role of astrocytes in neuronal energetic production and its relationship with neurodegeneration
by: Gloria Patricia Cardona Gomez
Published: (2015-03-01)

Astrocytes of the eye and optic nerve: heterogeneous populations with unique functions mediate axonal resilience and vulnerability to glaucoma
by: Paul F. Cullen, et al.
Published: (2023-07-01)

Astrocytes as a Therapeutic Target in Alzheimer’s Disease–Comprehensive Review and Recent Developments
by: Mateo Rodríguez-Giraldo, et al.
Published: (2022-11-01)

The Multifaceted Neurotoxicity of Astrocytes in Ageing and Age-Related Neurodegenerative Diseases: A Translational Perspective
by: David S. Bouvier, et al.
Published: (2022-03-01)

Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity
by: Elizabeth E. Evans, et al.
Published: (2022-08-01)

SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegeneration
by: Surya Chandra Rao Thumu, et al.
Published: (2024-01-01)

Mitochondrial Permeability Transition, Cell Death and Neurodegeneration
by: Artyom Y. Baev, et al.
Published: (2024-04-01)

Interleukin-1β Protects Neurons against Oxidant-Induced Injury via the Promotion of Astrocyte Glutathione Production
by: Twinkle Chowdhury, et al.
Published: (2018-07-01)

Non-Cell Autonomous and Epigenetic Mechanisms of Huntington’s Disease
by: Chaebin Kim, et al.
Published: (2021-11-01)

Astrocyte elevated gene-1 regulates astrocyte responses to neural injury: implications for reactive astrogliosis and neurodegeneration
by: Vartak-Sharma Neha, et al.
Published: (2012-08-01)

Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension
by: Shruthi Karnam, et al.
Published: (2024-04-01)

Glia in Neurodegeneration: The Housekeeper, the Defender and the Perpetrator
by: Carrie Sheeler, et al.
Published: (2020-12-01)

Siponimod (BAF312) Activates Nrf2 While Hampering NFκB in Human Astrocytes, and Protects From Astrocyte-Induced Neurodegeneration
by: Emanuela Colombo, et al.
Published: (2020-04-01)

Microglia and astrocyte dysfunction in parkinson's disease
by: Tae-In Kam, et al.
Published: (2020-10-01)

Astrocytic modulation of Blood Brain Barrier: Perspectives on Parkinson´s Disease
by: Ricardo eCabezas, et al.
Published: (2014-08-01)

Does neuroinflammation turn on the flame in Alzheimer's disease? Focus on astrocytes
by: Luca eSteardo, et al.
Published: (2015-07-01)

Editorial: Neuroinflammation and neurodegeneration from bench to bedside
by: Wael M. Y. Mohamed, et al.
Published: (2023-10-01)

Astrocytes and Aging
by: Alexandra L. Palmer, et al.
Published: (2018-10-01)

Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson’s disease
by: Eric Wildon Kostuk, et al.
Published: (2018-05-01)

Astrocyte remodeling without gliosis precedes optic nerve axonopathy
by: Melissa L. Cooper, et al.
Published: (2018-05-01)

Stress-Induced Depression and Alzheimer’s Disease: Focus on Astrocytes
by: Oleg V. Dolotov, et al.
Published: (2022-04-01)

Role of Senescent Astrocytes in Health and Disease
by: Jacopo Meldolesi
Published: (2023-05-01)

Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis
by: Markley Silva Oliveira Junior, et al.
Published: (2024-01-01)

Autonomic Changes in Juvenile-Onset Huntington’s Disease
by: Jordan L. Schultz, et al.
Published: (2020-08-01)

Beyond the GFAP-Astrocyte Protein Markers in the Brain
by: Agnieszka M. Jurga, et al.
Published: (2021-09-01)

The Relevance of Astrocytic Cell Culture Models for Neuroinflammation in Neurodegeneration Research
by: André Maciel Preato, et al.
Published: (2024-02-01)