Long non-coding RNAs as potential novel prognostic biomarkers in colorectal cancer
Colorectal cancer (CRC) is the fourth most common cause of death worldwide. Surgery is usually the first line of treatment for patients with CRC but many tumors with similar histopathological features show significantly different clinical outcomes. The discovery of robust prognostic biomarkers in pa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-04-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00054/full |
| _version_ | 1828491669271478272 |
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| author | Ester eSaus Ester eSaus Anna eBrunet-Vega Susana eIraola-Guzmán Susana eIraola-Guzmán Cinta ePegueroles Cinta ePegueroles Toni eGabaldón Toni eGabaldón Toni eGabaldón Carles ePericay |
| author_facet | Ester eSaus Ester eSaus Anna eBrunet-Vega Susana eIraola-Guzmán Susana eIraola-Guzmán Cinta ePegueroles Cinta ePegueroles Toni eGabaldón Toni eGabaldón Toni eGabaldón Carles ePericay |
| author_sort | Ester eSaus |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the fourth most common cause of death worldwide. Surgery is usually the first line of treatment for patients with CRC but many tumors with similar histopathological features show significantly different clinical outcomes. The discovery of robust prognostic biomarkers in patients with CRC is imperative to achieve more effective treatment strategies and improve patient’s care. Recent progress in next generation sequencing methods and transcriptome analysis has revealed that a much larger part of the genome is transcribed into RNA than previously assumed. Collectively referred to as non-coding RNAs (ncRNAs), some of these RNA molecules such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have been shown to be altered and to play critical roles in tumor biology. This discovery leads to exciting possibilities for personalized cancer diagnosis, and therapy. Many lncRNAs are tissue and cancer-type specific and have already revealed to be useful as prognostic markers. In this review, we focus on recent findings concerning aberrant expression of lncRNAs in CRC tumors and emphasize their prognostic potential in CRC. Further studies focused on the mechanisms of action of lncRNAs will contribute to the development of novel biomarkers for diagnosis and disease progression. |
| first_indexed | 2024-12-11T11:06:46Z |
| format | Article |
| id | doaj.art-43f19dc529174f12b53e38c813a1aa90 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-11T11:06:46Z |
| publishDate | 2016-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-43f19dc529174f12b53e38c813a1aa902022-12-22T01:09:40ZengFrontiers Media S.A.Frontiers in Genetics1664-80212016-04-01710.3389/fgene.2016.00054175734Long non-coding RNAs as potential novel prognostic biomarkers in colorectal cancerEster eSaus0Ester eSaus1Anna eBrunet-Vega2Susana eIraola-Guzmán3Susana eIraola-Guzmán4Cinta ePegueroles5Cinta ePegueroles6Toni eGabaldón7Toni eGabaldón8Toni eGabaldón9Carles ePericay10Centre for Genomic Regulation (CRG)Universitat Pompeu Fabra (UPF)Corporació Sanitària Parc Taulí - University Institute UABCentre for Genomic Regulation (CRG)Universitat Pompeu Fabra (UPF)Centre for Genomic Regulation (CRG)Universitat Pompeu Fabra (UPF)Centre for Genomic Regulation (CRG)Universitat Pompeu Fabra (UPF)Institució Catalana de Recerca i Estudis Avançats (ICREA)Corporació Sanitària Parc Taulí - University Institue UABColorectal cancer (CRC) is the fourth most common cause of death worldwide. Surgery is usually the first line of treatment for patients with CRC but many tumors with similar histopathological features show significantly different clinical outcomes. The discovery of robust prognostic biomarkers in patients with CRC is imperative to achieve more effective treatment strategies and improve patient’s care. Recent progress in next generation sequencing methods and transcriptome analysis has revealed that a much larger part of the genome is transcribed into RNA than previously assumed. Collectively referred to as non-coding RNAs (ncRNAs), some of these RNA molecules such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have been shown to be altered and to play critical roles in tumor biology. This discovery leads to exciting possibilities for personalized cancer diagnosis, and therapy. Many lncRNAs are tissue and cancer-type specific and have already revealed to be useful as prognostic markers. In this review, we focus on recent findings concerning aberrant expression of lncRNAs in CRC tumors and emphasize their prognostic potential in CRC. Further studies focused on the mechanisms of action of lncRNAs will contribute to the development of novel biomarkers for diagnosis and disease progression.http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00054/fullbiomarkercolorectal cancerncRNAlong non-coding RNAprognostic marker |
| spellingShingle | Ester eSaus Ester eSaus Anna eBrunet-Vega Susana eIraola-Guzmán Susana eIraola-Guzmán Cinta ePegueroles Cinta ePegueroles Toni eGabaldón Toni eGabaldón Toni eGabaldón Carles ePericay Long non-coding RNAs as potential novel prognostic biomarkers in colorectal cancer Frontiers in Genetics biomarker colorectal cancer ncRNA long non-coding RNA prognostic marker |
| title | Long non-coding RNAs as potential novel prognostic biomarkers in colorectal cancer |
| title_full | Long non-coding RNAs as potential novel prognostic biomarkers in colorectal cancer |
| title_fullStr | Long non-coding RNAs as potential novel prognostic biomarkers in colorectal cancer |
| title_full_unstemmed | Long non-coding RNAs as potential novel prognostic biomarkers in colorectal cancer |
| title_short | Long non-coding RNAs as potential novel prognostic biomarkers in colorectal cancer |
| title_sort | long non coding rnas as potential novel prognostic biomarkers in colorectal cancer |
| topic | biomarker colorectal cancer ncRNA long non-coding RNA prognostic marker |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00054/full |
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