Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight
In this study, the association between maternal age at menarche (AAM)-related polymorphisms and offspring birth weight (BW) was studied. The work was performed on a sample of 716 pregnant women and their newborns. All pregnant women underwent genotyping of 50 SNPs of AAM candidate genes. Regression...
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MDPI AG
2023-07-01
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| author | Yuliya Reshetnikova Maria Churnosova Vadim Stepanov Anna Bocharova Victoria Serebrova Ekaterina Trifonova Irina Ponomarenko Inna Sorokina Olga Efremova Valentina Orlova Irina Batlutskaya Marina Ponomarenko Vladimir Churnosov Natalya Eliseeva Inna Aristova Alexey Polonikov Evgeny Reshetnikov Mikhail Churnosov |
| author_facet | Yuliya Reshetnikova Maria Churnosova Vadim Stepanov Anna Bocharova Victoria Serebrova Ekaterina Trifonova Irina Ponomarenko Inna Sorokina Olga Efremova Valentina Orlova Irina Batlutskaya Marina Ponomarenko Vladimir Churnosov Natalya Eliseeva Inna Aristova Alexey Polonikov Evgeny Reshetnikov Mikhail Churnosov |
| author_sort | Yuliya Reshetnikova |
| collection | DOAJ |
| description | In this study, the association between maternal age at menarche (AAM)-related polymorphisms and offspring birth weight (BW) was studied. The work was performed on a sample of 716 pregnant women and their newborns. All pregnant women underwent genotyping of 50 SNPs of AAM candidate genes. Regression methods (linear and Model-Based Multifactor Dimensionality Reduction (MB-MDR)) with permutation procedures (the indicator p<sub>perm</sub> was calculated) were used to identify the correlation between SNPs and newborn weight (transformed BW values were analyzed) and in silico bioinformatic examination was applied to assess the intended functionality of BW-associated loci. Four AAM-related genetic variants were BW-associated including genes such as <i>POMC</i> (rs7589318) (β<sub>additive</sub> = 0.202/p<sub>perm</sub> = 0.015), <i>KDM3B</i> (rs757647) (β<sub>recessive</sub> = 0.323/p<sub>perm</sub> = 0.005), <i>INHBA</i> (rs1079866) (β<sub>additive</sub> = 0.110/p<sub>perm</sub> = 0.014) and <i>NKX2-1</i> (rs999460) (β<i><sub>recessive</sub></i> = −0.176/p<sub>perm</sub> = 0.015). Ten BW-significant models of interSNPs interactions (p<sub>perm</sub> ≤ 0.001) were identified for 20 polymorphisms. SNPs rs7538038 <i>KISS1</i>, rs713586 <i>RBJ</i>, rs12324955 <i>FTO</i> and rs713586 <i>RBJ</i>–rs12324955 <i>FTO</i> two-locus interaction were included in the largest number of BW-associated models (30% models each). BW-associated AAM-linked 22 SNPs and 350 proxy loci were functionally related to 49 genes relevant to pathways such as the hormone biosynthesis/process and female/male gonad development. In conclusion, maternal AMM-related genes polymorphism is associated with the offspring BW. |
| first_indexed | 2024-03-11T00:53:41Z |
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| publishDate | 2023-07-01 |
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| spelling | doaj.art-43f478e820604b9aa29f5be3ad947e0b2023-11-18T20:09:43ZengMDPI AGLife2075-17292023-07-01137152510.3390/life13071525Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth WeightYuliya Reshetnikova0Maria Churnosova1Vadim Stepanov2Anna Bocharova3Victoria Serebrova4Ekaterina Trifonova5Irina Ponomarenko6Inna Sorokina7Olga Efremova8Valentina Orlova9Irina Batlutskaya10Marina Ponomarenko11Vladimir Churnosov12Natalya Eliseeva13Inna Aristova14Alexey Polonikov15Evgeny Reshetnikov16Mikhail Churnosov17Department of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaResearch Institute for Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634050 Tomsk, RussiaResearch Institute for Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634050 Tomsk, RussiaResearch Institute for Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634050 Tomsk, RussiaResearch Institute for Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634050 Tomsk, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaIn this study, the association between maternal age at menarche (AAM)-related polymorphisms and offspring birth weight (BW) was studied. The work was performed on a sample of 716 pregnant women and their newborns. All pregnant women underwent genotyping of 50 SNPs of AAM candidate genes. Regression methods (linear and Model-Based Multifactor Dimensionality Reduction (MB-MDR)) with permutation procedures (the indicator p<sub>perm</sub> was calculated) were used to identify the correlation between SNPs and newborn weight (transformed BW values were analyzed) and in silico bioinformatic examination was applied to assess the intended functionality of BW-associated loci. Four AAM-related genetic variants were BW-associated including genes such as <i>POMC</i> (rs7589318) (β<sub>additive</sub> = 0.202/p<sub>perm</sub> = 0.015), <i>KDM3B</i> (rs757647) (β<sub>recessive</sub> = 0.323/p<sub>perm</sub> = 0.005), <i>INHBA</i> (rs1079866) (β<sub>additive</sub> = 0.110/p<sub>perm</sub> = 0.014) and <i>NKX2-1</i> (rs999460) (β<i><sub>recessive</sub></i> = −0.176/p<sub>perm</sub> = 0.015). Ten BW-significant models of interSNPs interactions (p<sub>perm</sub> ≤ 0.001) were identified for 20 polymorphisms. SNPs rs7538038 <i>KISS1</i>, rs713586 <i>RBJ</i>, rs12324955 <i>FTO</i> and rs713586 <i>RBJ</i>–rs12324955 <i>FTO</i> two-locus interaction were included in the largest number of BW-associated models (30% models each). BW-associated AAM-linked 22 SNPs and 350 proxy loci were functionally related to 49 genes relevant to pathways such as the hormone biosynthesis/process and female/male gonad development. In conclusion, maternal AMM-related genes polymorphism is associated with the offspring BW.https://www.mdpi.com/2075-1729/13/7/1525birth weightsingle nucleotide polymorphismassociationage of menarche |
| spellingShingle | Yuliya Reshetnikova Maria Churnosova Vadim Stepanov Anna Bocharova Victoria Serebrova Ekaterina Trifonova Irina Ponomarenko Inna Sorokina Olga Efremova Valentina Orlova Irina Batlutskaya Marina Ponomarenko Vladimir Churnosov Natalya Eliseeva Inna Aristova Alexey Polonikov Evgeny Reshetnikov Mikhail Churnosov Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight Life birth weight single nucleotide polymorphism association age of menarche |
| title | Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight |
| title_full | Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight |
| title_fullStr | Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight |
| title_full_unstemmed | Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight |
| title_short | Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight |
| title_sort | maternal age at menarche gene polymorphisms are associated with offspring birth weight |
| topic | birth weight single nucleotide polymorphism association age of menarche |
| url | https://www.mdpi.com/2075-1729/13/7/1525 |
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