Organic Fluorophores for 1064 nm Excited NIR-II Fluorescence Imaging
Second near-infrared window (NIR-II) fluorescence imaging has shown great potential in the field of bioimaging. However, the excitation wavelengths of most NIR-II fluorescence dyes are in the first near-infrared (NIR-I) region, which leads to limited imaging depth and resolution. To address such iss...
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| Format: | Article |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2021.769655/full |
| _version_ | 1819043710107648000 |
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| author | Wenqi Wang Xiaowen He Mingzhi Du Chen Xie Wen Zhou Wei Huang Quli Fan |
| author_facet | Wenqi Wang Xiaowen He Mingzhi Du Chen Xie Wen Zhou Wei Huang Quli Fan |
| author_sort | Wenqi Wang |
| collection | DOAJ |
| description | Second near-infrared window (NIR-II) fluorescence imaging has shown great potential in the field of bioimaging. However, the excitation wavelengths of most NIR-II fluorescence dyes are in the first near-infrared (NIR-I) region, which leads to limited imaging depth and resolution. To address such issue, NIR-II fluorescence dyes with 1,064 nm excitation have been developed and applied for in vivo imaging. Compared with NIR-I wavelength excited dyes, 1,064 nm excited dyes exhibit a higher tissue penetration depth and resolution. The improved performance makes these dyes have much broader imaging applications. In this mini review, we summarize recent advances in 1,064 nm excited NIR-II fluorescence fluorophores for bioimaging. Two kinds of organic fluorophores, small molecule dye and semiconducting polymer (SP), are reviewed. The general properties of these fluorophores are first introduced. Small molecule dyes with different chemical structures for variety of bioimaging applications are then discussed, followed by the introduction of SPs for NIR-II phototheranostics. Finally, the conclusion and future perspective of this field is given. |
| first_indexed | 2024-12-21T10:01:06Z |
| format | Article |
| id | doaj.art-43f513d9babd4d47bf265cd1e6362b1f |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-21T10:01:06Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Chemistry |
| spelling | doaj.art-43f513d9babd4d47bf265cd1e6362b1f2022-12-21T19:07:57ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-11-01910.3389/fchem.2021.769655769655Organic Fluorophores for 1064 nm Excited NIR-II Fluorescence ImagingWenqi Wang0Xiaowen He1Mingzhi Du2Chen Xie3Wen Zhou4Wei Huang5Quli Fan6Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing, ChinaKey Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing, ChinaKey Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing, ChinaKey Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing, ChinaKey Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing, ChinaFrontiers Science Center for Flexible Electronics (FSCFE), MIIT Key Laboratory of Flexible Electronics (KLoFE), Northwestern Polytechnical University, Xi’an, ChinaKey Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing, ChinaSecond near-infrared window (NIR-II) fluorescence imaging has shown great potential in the field of bioimaging. However, the excitation wavelengths of most NIR-II fluorescence dyes are in the first near-infrared (NIR-I) region, which leads to limited imaging depth and resolution. To address such issue, NIR-II fluorescence dyes with 1,064 nm excitation have been developed and applied for in vivo imaging. Compared with NIR-I wavelength excited dyes, 1,064 nm excited dyes exhibit a higher tissue penetration depth and resolution. The improved performance makes these dyes have much broader imaging applications. In this mini review, we summarize recent advances in 1,064 nm excited NIR-II fluorescence fluorophores for bioimaging. Two kinds of organic fluorophores, small molecule dye and semiconducting polymer (SP), are reviewed. The general properties of these fluorophores are first introduced. Small molecule dyes with different chemical structures for variety of bioimaging applications are then discussed, followed by the introduction of SPs for NIR-II phototheranostics. Finally, the conclusion and future perspective of this field is given.https://www.frontiersin.org/articles/10.3389/fchem.2021.769655/fullNIR-II fluorescence imaging1,064 nm excitationphotothermal therapyphototheranosticsorganic fluorophores |
| spellingShingle | Wenqi Wang Xiaowen He Mingzhi Du Chen Xie Wen Zhou Wei Huang Quli Fan Organic Fluorophores for 1064 nm Excited NIR-II Fluorescence Imaging Frontiers in Chemistry NIR-II fluorescence imaging 1,064 nm excitation photothermal therapy phototheranostics organic fluorophores |
| title | Organic Fluorophores for 1064 nm Excited NIR-II Fluorescence Imaging |
| title_full | Organic Fluorophores for 1064 nm Excited NIR-II Fluorescence Imaging |
| title_fullStr | Organic Fluorophores for 1064 nm Excited NIR-II Fluorescence Imaging |
| title_full_unstemmed | Organic Fluorophores for 1064 nm Excited NIR-II Fluorescence Imaging |
| title_short | Organic Fluorophores for 1064 nm Excited NIR-II Fluorescence Imaging |
| title_sort | organic fluorophores for 1064 nm excited nir ii fluorescence imaging |
| topic | NIR-II fluorescence imaging 1,064 nm excitation photothermal therapy phototheranostics organic fluorophores |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2021.769655/full |
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