Joint modelling of multivariate longitudinal clinical laboratory safety outcomes, concomitant medication and clinical adverse events: application to artemisinin-based treatment during pregnancy clinical trial

Joint modelling of multivariate longitudinal clinical laboratory safety outcomes, concomitant medication and clinical adverse events: application to artemisinin-based treatment during pregnancy clinical trial

Abstract Background In drug trials, clinical adverse events (AEs), concomitant medication and laboratory safety outcomes are repeatedly collected to support drug safety evidence. Despite the potential correlation of these outcomes, they are typically analysed separately, potentially leading to misin...

Full description

Bibliographic Details
Main Authors: Noel Patson, Mavuto Mukaka, Umberto D’Alessandro, Gertrude Chapotera, Victor Mwapasa, Don Mathanga, Lawrence Kazembe, Miriam K. Laufer, Tobias Chirwa
Format: Article
Language:English
Published: BMC 2021-10-01
Series:BMC Medical Research Methodology
Subjects:
Adverse events
Randomised controlled trials
Joint model
Drug safety
Concomitant medication
Online Access:https://doi.org/10.1186/s12874-021-01412-9

Similar Items

Similar Items