Analysis of prognostic factors for Tis-2N0M0 early glottic cancer with different treatment methods
Introduction: In many regions, laryngeal carcinoma is a common upper respiratory tract cancer, most commonly involving the glottic region. The treatment of early glottic cancer includes radiotherapy, open surgery and laryngeal laser microsurgery. However, the preferred treatment for early glottic ca...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Brazilian Journal of Otorhinolaryngology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1808869420301130 |
| _version_ | 1818219223211573248 |
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| author | Guanyu Wang Guodong Li Jianjun Wu Penghui Song |
| author_facet | Guanyu Wang Guodong Li Jianjun Wu Penghui Song |
| author_sort | Guanyu Wang |
| collection | DOAJ |
| description | Introduction: In many regions, laryngeal carcinoma is a common upper respiratory tract cancer, most commonly involving the glottic region. The treatment of early glottic cancer includes radiotherapy, open surgery and laryngeal laser microsurgery. However, the preferred treatment for early glottic cancer is still controversial. Objectives: To study the factors affecting the 5-year survival rate of Tis-2N0M0 early glottis cancer and to demonstrate the oncological safety of different treatments. Methods: 144 patients with early glottic cancer were analyzed retrospectively. All patients were clinically node negative. 53 patients underwent open surgery, transoral CO2 laser microsurgery in 46 cases and radiotherapy in 45 cases. The patients were followed up for 26 − 84 months, with an average follow-up period of 62.9 months. Results: The 5-year overall survival was 82.6%. The 5 year survival rates of open surgery, laser microsurgery and radiotherapy were 83.0%, 82.6% and 82.2%, respectively. There was no significant difference in 5-year survival rate among the three treatments (p = 0.987). In multivariate analysis, age, T-stage, pathological grading, and anterior commissure involvement were important prognostic factors for early glottic cancer. Conclusion: There was no significant difference in 5 year survival rate among patients treated by either radiotherapy, laser microsurgery or open surgery for early glottic cancer. We urge more attention to the age, T-stage, pathological grade, and anterior commissure involvement of the patients. |
| first_indexed | 2024-12-12T07:36:14Z |
| format | Article |
| id | doaj.art-43f5c8e3bf5148228e53cb1120d6ece8 |
| institution | Directory Open Access Journal |
| issn | 1808-8694 |
| language | English |
| last_indexed | 2024-12-12T07:36:14Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj.art-43f5c8e3bf5148228e53cb1120d6ece82022-12-22T00:32:55ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86942022-05-01883375380Analysis of prognostic factors for Tis-2N0M0 early glottic cancer with different treatment methodsGuanyu Wang0Guodong Li1Jianjun Wu2Penghui Song3Heping Hospital Affiliated to Changzhi Medical College, Department of Radiotherapy, Changzhi, ChinaShanxi Provincial People’s Hospital Affiliated to Shanxi Medical University, Department of Otolaryngology, Taiyuan, ChinaHeping Hospital Affiliated to Changzhi Medical College, Department of Radiotherapy, Changzhi, ChinaHeping Hospital Affiliated to Changzhi Medical College, Department of Radiotherapy, Changzhi, China; Corresponding author.Introduction: In many regions, laryngeal carcinoma is a common upper respiratory tract cancer, most commonly involving the glottic region. The treatment of early glottic cancer includes radiotherapy, open surgery and laryngeal laser microsurgery. However, the preferred treatment for early glottic cancer is still controversial. Objectives: To study the factors affecting the 5-year survival rate of Tis-2N0M0 early glottis cancer and to demonstrate the oncological safety of different treatments. Methods: 144 patients with early glottic cancer were analyzed retrospectively. All patients were clinically node negative. 53 patients underwent open surgery, transoral CO2 laser microsurgery in 46 cases and radiotherapy in 45 cases. The patients were followed up for 26 − 84 months, with an average follow-up period of 62.9 months. Results: The 5-year overall survival was 82.6%. The 5 year survival rates of open surgery, laser microsurgery and radiotherapy were 83.0%, 82.6% and 82.2%, respectively. There was no significant difference in 5-year survival rate among the three treatments (p = 0.987). In multivariate analysis, age, T-stage, pathological grading, and anterior commissure involvement were important prognostic factors for early glottic cancer. Conclusion: There was no significant difference in 5 year survival rate among patients treated by either radiotherapy, laser microsurgery or open surgery for early glottic cancer. We urge more attention to the age, T-stage, pathological grade, and anterior commissure involvement of the patients.http://www.sciencedirect.com/science/article/pii/S1808869420301130Glottic cancer5-year survival rateLaser microsurgeryRadiotherapyPrognostic factors |
| spellingShingle | Guanyu Wang Guodong Li Jianjun Wu Penghui Song Analysis of prognostic factors for Tis-2N0M0 early glottic cancer with different treatment methods Brazilian Journal of Otorhinolaryngology Glottic cancer 5-year survival rate Laser microsurgery Radiotherapy Prognostic factors |
| title | Analysis of prognostic factors for Tis-2N0M0 early glottic cancer with different treatment methods |
| title_full | Analysis of prognostic factors for Tis-2N0M0 early glottic cancer with different treatment methods |
| title_fullStr | Analysis of prognostic factors for Tis-2N0M0 early glottic cancer with different treatment methods |
| title_full_unstemmed | Analysis of prognostic factors for Tis-2N0M0 early glottic cancer with different treatment methods |
| title_short | Analysis of prognostic factors for Tis-2N0M0 early glottic cancer with different treatment methods |
| title_sort | analysis of prognostic factors for tis 2n0m0 early glottic cancer with different treatment methods |
| topic | Glottic cancer 5-year survival rate Laser microsurgery Radiotherapy Prognostic factors |
| url | http://www.sciencedirect.com/science/article/pii/S1808869420301130 |
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