Early Alterations of RNA Binding Protein (RBP) Homeostasis and ER Stress-Mediated Autophagy Contributes to Progressive Retinal Degeneration in the <i>rd10</i> Mouse Model of Retinitis Pigmentosa (RP)

Early Alterations of RNA Binding Protein (RBP) Homeostasis and ER Stress-Mediated Autophagy Contributes to Progressive Retinal Degeneration in the <i>rd10</i> Mouse Model of Retinitis Pigmentosa (RP)

The retinal degeneration 10 (<i>rd10</i>) mouse model is widely used to study retinitis pigmentosa (RP) pathomechanisms. It offers a rather unique opportunity to study trans-neuronal degeneration because the cell populations in question are separated anatomically and the mutated <i>...

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Bibliographic Details
Main Authors: Alfred Yamoah, Priyanka Tripathi, Haihong Guo, Leonie Scheve, Peter Walter, Sandra Johnen, Frank Müller, Joachim Weis, Anand Goswami
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
<i>rd10</i> retina
ER-Ca<sup>2+</sup> homeostasis
ER chaperones
autophagy
RBP aggregation
neurodegeneration
Online Access:https://www.mdpi.com/2073-4409/12/7/1094

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