Design, synthesis and anticancer evaluation of chalcone derivatives of oxazol-4-yl)-2-morpholinothiazole as anticancer agents
A new library of chalcone derivatives of oxazol-4-yl)-2-morpholinothiazole (10a-j) have been developed and synthesized. All these synthesized compounds were firmed by 1H NMR, 13C NMR and mass spectral data. Further, the in vitro anticancer effects of newly derived compounds (10a-j) were investigated...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623002163 |
| _version_ | 1797799001970442240 |
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| author | Muralidhar Reddy Rachala Thirumala Chary Maringanti Laxminarayana Eppakayala |
| author_facet | Muralidhar Reddy Rachala Thirumala Chary Maringanti Laxminarayana Eppakayala |
| author_sort | Muralidhar Reddy Rachala |
| collection | DOAJ |
| description | A new library of chalcone derivatives of oxazol-4-yl)-2-morpholinothiazole (10a-j) have been developed and synthesized. All these synthesized compounds were firmed by 1H NMR, 13C NMR and mass spectral data. Further, the in vitro anticancer effects of newly derived compounds (10a-j) were investigated towards four human cancer cell lines including PC3 and DU-145 (prostate cancer), A549 (lung cancer) & MCF-7 (breast cancer) through MTT assay, and was compared with etoposide which is positive control. Most of the evaluated compounds displayed excellent to moderate activities than etoposide. Among all, compounds 10a, 10b, 10c, 10d, 10e and 10f exhibited more potent activity. Predominantly, one compound 10d displayed superior anticancer activity. |
| first_indexed | 2024-03-13T04:12:23Z |
| format | Article |
| id | doaj.art-43f7e4b98f0a40c29e8a067958d78d7d |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-03-13T04:12:23Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-43f7e4b98f0a40c29e8a067958d78d7d2023-06-21T06:52:47ZengElsevierResults in Chemistry2211-71562023-01-015100977Design, synthesis and anticancer evaluation of chalcone derivatives of oxazol-4-yl)-2-morpholinothiazole as anticancer agentsMuralidhar Reddy Rachala0Thirumala Chary Maringanti1Laxminarayana Eppakayala2Vidya Jyothi Institute of Technology, Aziz Nagar Gate, Hyderabad 500 075, Telangana, India; Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad 500 085, Telangana, IndiaJawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad 500 085, Telangana, India; Corresponding author.Sreenidhi Institute of Science and Technology (Autonomous), Ghatkesar, 501301 Telangana, IndiaA new library of chalcone derivatives of oxazol-4-yl)-2-morpholinothiazole (10a-j) have been developed and synthesized. All these synthesized compounds were firmed by 1H NMR, 13C NMR and mass spectral data. Further, the in vitro anticancer effects of newly derived compounds (10a-j) were investigated towards four human cancer cell lines including PC3 and DU-145 (prostate cancer), A549 (lung cancer) & MCF-7 (breast cancer) through MTT assay, and was compared with etoposide which is positive control. Most of the evaluated compounds displayed excellent to moderate activities than etoposide. Among all, compounds 10a, 10b, 10c, 10d, 10e and 10f exhibited more potent activity. Predominantly, one compound 10d displayed superior anticancer activity.http://www.sciencedirect.com/science/article/pii/S2211715623002163TiazofurinThiazoleIsoliquiritigeninChalconeAnticancer activity |
| spellingShingle | Muralidhar Reddy Rachala Thirumala Chary Maringanti Laxminarayana Eppakayala Design, synthesis and anticancer evaluation of chalcone derivatives of oxazol-4-yl)-2-morpholinothiazole as anticancer agents Results in Chemistry Tiazofurin Thiazole Isoliquiritigenin Chalcone Anticancer activity |
| title | Design, synthesis and anticancer evaluation of chalcone derivatives of oxazol-4-yl)-2-morpholinothiazole as anticancer agents |
| title_full | Design, synthesis and anticancer evaluation of chalcone derivatives of oxazol-4-yl)-2-morpholinothiazole as anticancer agents |
| title_fullStr | Design, synthesis and anticancer evaluation of chalcone derivatives of oxazol-4-yl)-2-morpholinothiazole as anticancer agents |
| title_full_unstemmed | Design, synthesis and anticancer evaluation of chalcone derivatives of oxazol-4-yl)-2-morpholinothiazole as anticancer agents |
| title_short | Design, synthesis and anticancer evaluation of chalcone derivatives of oxazol-4-yl)-2-morpholinothiazole as anticancer agents |
| title_sort | design synthesis and anticancer evaluation of chalcone derivatives of oxazol 4 yl 2 morpholinothiazole as anticancer agents |
| topic | Tiazofurin Thiazole Isoliquiritigenin Chalcone Anticancer activity |
| url | http://www.sciencedirect.com/science/article/pii/S2211715623002163 |
| work_keys_str_mv | AT muralidharreddyrachala designsynthesisandanticancerevaluationofchalconederivativesofoxazol4yl2morpholinothiazoleasanticanceragents AT thirumalacharymaringanti designsynthesisandanticancerevaluationofchalconederivativesofoxazol4yl2morpholinothiazoleasanticanceragents AT laxminarayanaeppakayala designsynthesisandanticancerevaluationofchalconederivativesofoxazol4yl2morpholinothiazoleasanticanceragents |