Pharmacological Treatment of Alzheimer’s Disease: Insights from <i>Drosophila melanogaster</i>
Aging is an ineluctable law of life. During the process of aging, the occurrence of neurodegenerative disorders is prevalent in the elderly population and the predominant type of dementia is Alzheimer’s disease (AD). The clinical symptoms of AD include progressive memory loss and impairment of cogni...
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MDPI AG
2020-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/13/4621 |
| _version_ | 1797563866149814272 |
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| author | Xingyi Cheng Chaochun Song Yanjiao Du Uma Gaur Mingyao Yang |
| author_facet | Xingyi Cheng Chaochun Song Yanjiao Du Uma Gaur Mingyao Yang |
| author_sort | Xingyi Cheng |
| collection | DOAJ |
| description | Aging is an ineluctable law of life. During the process of aging, the occurrence of neurodegenerative disorders is prevalent in the elderly population and the predominant type of dementia is Alzheimer’s disease (AD). The clinical symptoms of AD include progressive memory loss and impairment of cognitive functions that interfere with daily life activities. The predominant neuropathological features in AD are extracellular β-amyloid (Aβ) plaque deposition and intracellular neurofibrillary tangles (NFTs) of hyperphosphorylated Tau. Because of its complex pathobiology, some tangible treatment can only ameliorate the symptoms, but not prevent the disease altogether. Numerous drugs during pre-clinical or clinical studies have shown no positive effect on the disease outcome. Therefore, understanding the basic pathophysiological mechanism of AD is imperative for the rational design of drugs that can be used to prevent this disease. <i>Drosophila</i> <i>melanogaster</i> has emerged as a highly efficient model system to explore the pathogenesis and treatment of AD. In this review we have summarized recent advancements in the pharmacological research on AD using <i>Drosophila</i> as a model species, discussed feasible treatment strategies and provided further reference for the mechanistic study and treatment of age-related AD. |
| first_indexed | 2024-03-10T18:48:17Z |
| format | Article |
| id | doaj.art-43f887c4b27f422082c5fecff85366f8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:48:17Z |
| publishDate | 2020-06-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-43f887c4b27f422082c5fecff85366f82023-11-20T05:18:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-06-012113462110.3390/ijms21134621Pharmacological Treatment of Alzheimer’s Disease: Insights from <i>Drosophila melanogaster</i>Xingyi Cheng0Chaochun Song1Yanjiao Du2Uma Gaur3Mingyao Yang4Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaAging is an ineluctable law of life. During the process of aging, the occurrence of neurodegenerative disorders is prevalent in the elderly population and the predominant type of dementia is Alzheimer’s disease (AD). The clinical symptoms of AD include progressive memory loss and impairment of cognitive functions that interfere with daily life activities. The predominant neuropathological features in AD are extracellular β-amyloid (Aβ) plaque deposition and intracellular neurofibrillary tangles (NFTs) of hyperphosphorylated Tau. Because of its complex pathobiology, some tangible treatment can only ameliorate the symptoms, but not prevent the disease altogether. Numerous drugs during pre-clinical or clinical studies have shown no positive effect on the disease outcome. Therefore, understanding the basic pathophysiological mechanism of AD is imperative for the rational design of drugs that can be used to prevent this disease. <i>Drosophila</i> <i>melanogaster</i> has emerged as a highly efficient model system to explore the pathogenesis and treatment of AD. In this review we have summarized recent advancements in the pharmacological research on AD using <i>Drosophila</i> as a model species, discussed feasible treatment strategies and provided further reference for the mechanistic study and treatment of age-related AD.https://www.mdpi.com/1422-0067/21/13/4621Alzheimer’s diseaseAD modelpharmacologysignaling pathways<i>Drosophila</i> |
| spellingShingle | Xingyi Cheng Chaochun Song Yanjiao Du Uma Gaur Mingyao Yang Pharmacological Treatment of Alzheimer’s Disease: Insights from <i>Drosophila melanogaster</i> International Journal of Molecular Sciences Alzheimer’s disease AD model pharmacology signaling pathways <i>Drosophila</i> |
| title | Pharmacological Treatment of Alzheimer’s Disease: Insights from <i>Drosophila melanogaster</i> |
| title_full | Pharmacological Treatment of Alzheimer’s Disease: Insights from <i>Drosophila melanogaster</i> |
| title_fullStr | Pharmacological Treatment of Alzheimer’s Disease: Insights from <i>Drosophila melanogaster</i> |
| title_full_unstemmed | Pharmacological Treatment of Alzheimer’s Disease: Insights from <i>Drosophila melanogaster</i> |
| title_short | Pharmacological Treatment of Alzheimer’s Disease: Insights from <i>Drosophila melanogaster</i> |
| title_sort | pharmacological treatment of alzheimer s disease insights from i drosophila melanogaster i |
| topic | Alzheimer’s disease AD model pharmacology signaling pathways <i>Drosophila</i> |
| url | https://www.mdpi.com/1422-0067/21/13/4621 |
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