Cellular Biomarkers of Rejection in Lung Transplant: The Usefulness of Eosinophil and Lymphocyte Counts
There is increasing interest in the development of biomarkers of acute cellular rejection (ACR) and chronic allograft dysfunction (CLAD) in lung transplant recipients. However, few studies have focused on the predictive value of cellular biomarkers usually available in routine clinical practice such...
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| Format: | Article |
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Publicaciones Permanyer
2023-07-01
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| Series: | Barcelona Respiratory Network Reviews |
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| Online Access: | https://www.brnreviews.com/frame_esp.php?id=235 |
| _version_ | 1797486835366100992 |
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| author | Piedad Ussetti Silvia Aguado Rosalía Laporta |
| author_facet | Piedad Ussetti Silvia Aguado Rosalía Laporta |
| author_sort | Piedad Ussetti |
| collection | DOAJ |
| description | There is increasing interest in the development of biomarkers of acute cellular rejection (ACR) and chronic allograft dysfunction (CLAD) in lung transplant recipients. However, few studies have focused on the predictive value of cellular biomarkers usually available in routine clinical practice such as eosinophils (EOS) and lymphocytes.
Peripheral blood eosinophilia has been associated with ACR in kidney, heart and liver transplant recipients. There are few studies in relation to EOS counts in lung transplants. In our experience, the increase in EOS in peripheral blood may be a warning sign of rejection that advises to expand the assessment with a bronchoscopy (FBS), transbronchial biopsy (TBB) and bronchoalveolar lavage (BAL).
Lymphocytes are essential cells in the development of ACR. The increase in lymphocytes in the BAL fluid (BALF) may be indicative of ACR, especially if it is associated with a simultaneous increase in the EOS count in the peripheral blood.
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| first_indexed | 2024-03-09T23:38:50Z |
| format | Article |
| id | doaj.art-43fdaa1025bf445a99b6330d10c7b2ff |
| institution | Directory Open Access Journal |
| issn | 2462-3172 |
| language | English |
| last_indexed | 2024-03-09T23:38:50Z |
| publishDate | 2023-07-01 |
| publisher | Publicaciones Permanyer |
| record_format | Article |
| series | Barcelona Respiratory Network Reviews |
| spelling | doaj.art-43fdaa1025bf445a99b6330d10c7b2ff2023-11-23T16:54:44ZengPublicaciones PermanyerBarcelona Respiratory Network Reviews2462-31722023-07-019310.23866/BRNRev:2023-M0094Cellular Biomarkers of Rejection in Lung Transplant: The Usefulness of Eosinophil and Lymphocyte CountsPiedad Ussetti0Silvia Aguado1Rosalía Laporta2Servicio de Neumología, Hospital Puerta de Hierro, Madrid, SpainServicio de Neumología, Hospital Puerta de Hierro, Madrid, SpainServicio de Neumología, Hospital Puerta de Hierro, Madrid, SpainThere is increasing interest in the development of biomarkers of acute cellular rejection (ACR) and chronic allograft dysfunction (CLAD) in lung transplant recipients. However, few studies have focused on the predictive value of cellular biomarkers usually available in routine clinical practice such as eosinophils (EOS) and lymphocytes. Peripheral blood eosinophilia has been associated with ACR in kidney, heart and liver transplant recipients. There are few studies in relation to EOS counts in lung transplants. In our experience, the increase in EOS in peripheral blood may be a warning sign of rejection that advises to expand the assessment with a bronchoscopy (FBS), transbronchial biopsy (TBB) and bronchoalveolar lavage (BAL). Lymphocytes are essential cells in the development of ACR. The increase in lymphocytes in the BAL fluid (BALF) may be indicative of ACR, especially if it is associated with a simultaneous increase in the EOS count in the peripheral blood. https://www.brnreviews.com/frame_esp.php?id=235Acute rejection. Bronchoalveolar lavage (BAL). Eosinophils. Lymphocytes. Peripheral blood. |
| spellingShingle | Piedad Ussetti Silvia Aguado Rosalía Laporta Cellular Biomarkers of Rejection in Lung Transplant: The Usefulness of Eosinophil and Lymphocyte Counts Barcelona Respiratory Network Reviews Acute rejection. Bronchoalveolar lavage (BAL). Eosinophils. Lymphocytes. Peripheral blood. |
| title | Cellular Biomarkers of Rejection in Lung Transplant: The Usefulness of Eosinophil and Lymphocyte Counts |
| title_full | Cellular Biomarkers of Rejection in Lung Transplant: The Usefulness of Eosinophil and Lymphocyte Counts |
| title_fullStr | Cellular Biomarkers of Rejection in Lung Transplant: The Usefulness of Eosinophil and Lymphocyte Counts |
| title_full_unstemmed | Cellular Biomarkers of Rejection in Lung Transplant: The Usefulness of Eosinophil and Lymphocyte Counts |
| title_short | Cellular Biomarkers of Rejection in Lung Transplant: The Usefulness of Eosinophil and Lymphocyte Counts |
| title_sort | cellular biomarkers of rejection in lung transplant the usefulness of eosinophil and lymphocyte counts |
| topic | Acute rejection. Bronchoalveolar lavage (BAL). Eosinophils. Lymphocytes. Peripheral blood. |
| url | https://www.brnreviews.com/frame_esp.php?id=235 |
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