High Molecular Weight ACTH-Precursor Presence in a Metastatic Pancreatic Neuroendocrine Tumor Causing Severe Ectopic Cushing's Syndrome: A Case Report

High Molecular Weight ACTH-Precursor Presence in a Metastatic Pancreatic Neuroendocrine Tumor Causing Severe Ectopic Cushing's Syndrome: A Case Report

Ectopic ACTH-secretion causing Cushing's syndrome is unusual and its diagnosis is frequently challenging. The presence of high-molecular-weight precursors throughout pro-opiomelanocortin (POMC) translation by these tumors is often not reported. We present the case of a 49-year-old woman with a...

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Bibliographic Details
Main Authors: Roopa Mehta, César Ernesto Lam-Chung, José Miguel Hinojosa-Amaya, Paola Roldán-Sarmiento, Maria Fernanda Guillen-Placencia, Gerladine Villanueva-Rodriguez, Oscar Alfredo Juarez-Leon, Jefsi Leon-Domínguez, Mariana Grajales-Gómez, Jose Luis Ventura-Gallegos, Andrés León-Suárez, Francisco J. Gómez-Pérez, Daniel Cuevas-Ramos
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Endocrinology
Subjects:
ACTH
ectopic
neuroendocrine tumor
cushing syndrome
case report
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00557/full

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