Therapeutic drug monitoring of vancomycin in an obese patient with renal insufficiency
We report the pharmacokinetics of vancomycin in an obese patient with renal insufficiency using pharmacokinetic equations, and comparing them with actual levels. A 47-year-old man with morbid obesity had a complicated hospital course with acute renal failure. Due to sputum growth of coagulase-negati...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Journal of Anaesthesiology Clinical Pharmacology |
| Subjects: | |
| Online Access: | http://www.joacp.org/article.asp?issn=0970-9185;year=2011;volume=27;issue=4;spage=531;epage=533;aulast=Abuhasna |
| _version_ | 1818160084851621888 |
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| author | Said Abuhasna Amer H Al Jundi |
| author_facet | Said Abuhasna Amer H Al Jundi |
| author_sort | Said Abuhasna |
| collection | DOAJ |
| description | We report the pharmacokinetics of vancomycin in an obese patient with renal insufficiency using pharmacokinetic equations, and comparing them with actual levels. A 47-year-old man with morbid obesity had a complicated hospital course with acute renal failure. Due to sputum growth of coagulase-negative Staphylococcus aureus, vancomycin 1500 mg intravenously twice daily was given empirically. Peak and trough plasma concentrations were drawn at steady state. Based on levels, true pharmacokinetic parameters for the patient were calculated using equations. This revealed that calculating individual pharmacokinetic parameters using equations may be a valid tool for dosing vancomycin in obese patients with renal insufficiency. |
| first_indexed | 2024-12-11T15:56:16Z |
| format | Article |
| id | doaj.art-43ff452e24e140269883f882b267efcf |
| institution | Directory Open Access Journal |
| issn | 0970-9185 |
| language | English |
| last_indexed | 2024-12-11T15:56:16Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Anaesthesiology Clinical Pharmacology |
| spelling | doaj.art-43ff452e24e140269883f882b267efcf2022-12-22T00:59:26ZengWolters Kluwer Medknow PublicationsJournal of Anaesthesiology Clinical Pharmacology0970-91852011-01-0127453153310.4103/0970-9185.86601Therapeutic drug monitoring of vancomycin in an obese patient with renal insufficiencySaid AbuhasnaAmer H Al JundiWe report the pharmacokinetics of vancomycin in an obese patient with renal insufficiency using pharmacokinetic equations, and comparing them with actual levels. A 47-year-old man with morbid obesity had a complicated hospital course with acute renal failure. Due to sputum growth of coagulase-negative Staphylococcus aureus, vancomycin 1500 mg intravenously twice daily was given empirically. Peak and trough plasma concentrations were drawn at steady state. Based on levels, true pharmacokinetic parameters for the patient were calculated using equations. This revealed that calculating individual pharmacokinetic parameters using equations may be a valid tool for dosing vancomycin in obese patients with renal insufficiency.http://www.joacp.org/article.asp?issn=0970-9185;year=2011;volume=27;issue=4;spage=531;epage=533;aulast=AbuhasnaObeserenal insufficiencyvancomycin therapeutic drug monitoring |
| spellingShingle | Said Abuhasna Amer H Al Jundi Therapeutic drug monitoring of vancomycin in an obese patient with renal insufficiency Journal of Anaesthesiology Clinical Pharmacology Obese renal insufficiency vancomycin therapeutic drug monitoring |
| title | Therapeutic drug monitoring of vancomycin in an obese patient with renal insufficiency |
| title_full | Therapeutic drug monitoring of vancomycin in an obese patient with renal insufficiency |
| title_fullStr | Therapeutic drug monitoring of vancomycin in an obese patient with renal insufficiency |
| title_full_unstemmed | Therapeutic drug monitoring of vancomycin in an obese patient with renal insufficiency |
| title_short | Therapeutic drug monitoring of vancomycin in an obese patient with renal insufficiency |
| title_sort | therapeutic drug monitoring of vancomycin in an obese patient with renal insufficiency |
| topic | Obese renal insufficiency vancomycin therapeutic drug monitoring |
| url | http://www.joacp.org/article.asp?issn=0970-9185;year=2011;volume=27;issue=4;spage=531;epage=533;aulast=Abuhasna |
| work_keys_str_mv | AT saidabuhasna therapeuticdrugmonitoringofvancomycininanobesepatientwithrenalinsufficiency AT amerhaljundi therapeuticdrugmonitoringofvancomycininanobesepatientwithrenalinsufficiency |