The transcription factor Pou4f3 is essential for the survival of postnatal and adult mouse cochlear hair cells and normal hearing

The transcription factor Pou4f3 is essential for the survival of postnatal and adult mouse cochlear hair cells and normal hearing

IntroductionHair cells (HCs) of the cochlea are responsible for sound transduction and hearing perception in mammals. Genetic mutations in the transcription factor Pou4f3 cause non-syndromic autosomal dominant hearing loss in humans (DFNA15) which varies in the age of onset depending on the individu...

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Bibliographic Details
Main Authors: Jarnail Singh, Michelle R. Randle, Bradley J. Walters, Brandon C. Cox
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Pou4f3
DFNA15
hearing loss
hair cell maturation
hair cell survival
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1369282/full

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