Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function

Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function

Abstract All irreversible Bruton tyrosine kinase (Btk) inhibitors including ibrutinib and acalabrutinib induce platelet dysfunction and increased bleeding risk. New reversible Btk inhibitors were developed, like MK‐1026. The mechanism underlying increased bleeding tendency with Btk inhibitors remain...

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Bibliographic Details
Main Authors: Bibian M.E. Tullemans, Mieke F.A. Karel, Valentine Léopold, Marieke S. ten Brink, Constance C.F.M.J. Baaten, Sanne L. Maas, Alex F. deVos, Johannes A. Eble, Marten R. Nijziel, Emiel P.C. van derVorst, Judith M.E.M. Cosemans, Johan W.M. Heemskerk, Theodora A.M. Claushuis, Marijke J.E. Kuijpers
Format: Article
Language:English
Published: Wiley 2021-11-01
Series:eJHaem
Subjects:
bleeding
Bruton tyrosine kinase
CLEC‐2
glycoprotein VI
platelets
von Willebrand Factor
Online Access:https://doi.org/10.1002/jha2.269

Internet

https://doi.org/10.1002/jha2.269

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