Neuroanatomical and neurocognitive changes associated with subjective cognitive decline
IntroductionSubjective Cognitive Decline (SCD) can progress to mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia and thus may represent a preclinical stage of the AD continuum. However, evidence about structural changes observed in the brain during SCD remains inconsistent.Materi...
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1094799/full |
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| author | Miguel Ángel Rivas-Fernández Miguel Ángel Rivas-Fernández Mónica Lindín Mónica Lindín Montserrat Zurrón Montserrat Zurrón Fernando Díaz Fernando Díaz Cristina Lojo-Seoane Cristina Lojo-Seoane Arturo X. Pereiro Arturo X. Pereiro Santiago Galdo-Álvarez Santiago Galdo-Álvarez |
| author_facet | Miguel Ángel Rivas-Fernández Miguel Ángel Rivas-Fernández Mónica Lindín Mónica Lindín Montserrat Zurrón Montserrat Zurrón Fernando Díaz Fernando Díaz Cristina Lojo-Seoane Cristina Lojo-Seoane Arturo X. Pereiro Arturo X. Pereiro Santiago Galdo-Álvarez Santiago Galdo-Álvarez |
| author_sort | Miguel Ángel Rivas-Fernández |
| collection | DOAJ |
| description | IntroductionSubjective Cognitive Decline (SCD) can progress to mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia and thus may represent a preclinical stage of the AD continuum. However, evidence about structural changes observed in the brain during SCD remains inconsistent.Materials and methodsThis cross-sectional study aimed to evaluate, in subjects recruited from the CompAS project, neurocognitive and neurostructural differences between a group of forty-nine control subjects and forty-nine individuals who met the diagnostic criteria for SCD and exhibited high levels of subjective cognitive complaints (SCCs). Structural magnetic resonance imaging was used to compare neuroanatomical differences in brain volume and cortical thickness between both groups.ResultsRelative to the control group, the SCD group displayed structural changes involving frontal, parietal, and medial temporal lobe regions of critical importance in AD etiology and functionally related to several cognitive domains, including executive control, attention, memory, and language.ConclusionDespite the absence of clinical deficits, SCD may constitute a preclinical entity with a similar (although subtle) pattern of neuroanatomical changes to that observed in individuals with amnestic MCI or AD dementia. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T18:22:10Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-4400d66ed1d343faafecac976c5a418b2023-02-02T07:06:03ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-02-011010.3389/fmed.2023.10947991094799Neuroanatomical and neurocognitive changes associated with subjective cognitive declineMiguel Ángel Rivas-Fernández0Miguel Ángel Rivas-Fernández1Mónica Lindín2Mónica Lindín3Montserrat Zurrón4Montserrat Zurrón5Fernando Díaz6Fernando Díaz7Cristina Lojo-Seoane8Cristina Lojo-Seoane9Arturo X. Pereiro10Arturo X. Pereiro11Santiago Galdo-Álvarez12Santiago Galdo-Álvarez13Department of Clinical Psychology and Psychobiology, Universidade de Santiago de Compostela, Santiago de Compostela, SpainCognitive Neuroscience Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, SpainDepartment of Clinical Psychology and Psychobiology, Universidade de Santiago de Compostela, Santiago de Compostela, SpainCognitive Neuroscience Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, SpainDepartment of Clinical Psychology and Psychobiology, Universidade de Santiago de Compostela, Santiago de Compostela, SpainCognitive Neuroscience Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, SpainDepartment of Clinical Psychology and Psychobiology, Universidade de Santiago de Compostela, Santiago de Compostela, SpainCognitive Neuroscience Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, SpainCognitive Neuroscience Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, SpainDepartment of Developmental and Educational Psychology, Universidade de Santiago de Compostela, Santiago de Compostela, SpainCognitive Neuroscience Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, SpainDepartment of Developmental and Educational Psychology, Universidade de Santiago de Compostela, Santiago de Compostela, SpainDepartment of Clinical Psychology and Psychobiology, Universidade de Santiago de Compostela, Santiago de Compostela, SpainCognitive Neuroscience Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, SpainIntroductionSubjective Cognitive Decline (SCD) can progress to mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia and thus may represent a preclinical stage of the AD continuum. However, evidence about structural changes observed in the brain during SCD remains inconsistent.Materials and methodsThis cross-sectional study aimed to evaluate, in subjects recruited from the CompAS project, neurocognitive and neurostructural differences between a group of forty-nine control subjects and forty-nine individuals who met the diagnostic criteria for SCD and exhibited high levels of subjective cognitive complaints (SCCs). Structural magnetic resonance imaging was used to compare neuroanatomical differences in brain volume and cortical thickness between both groups.ResultsRelative to the control group, the SCD group displayed structural changes involving frontal, parietal, and medial temporal lobe regions of critical importance in AD etiology and functionally related to several cognitive domains, including executive control, attention, memory, and language.ConclusionDespite the absence of clinical deficits, SCD may constitute a preclinical entity with a similar (although subtle) pattern of neuroanatomical changes to that observed in individuals with amnestic MCI or AD dementia.https://www.frontiersin.org/articles/10.3389/fmed.2023.1094799/fullAlzheimer’s diseasesubjective cognitive decline (SCD)structural magnetic resonance imagingbrain structural changessubjective cognitive complaints |
| spellingShingle | Miguel Ángel Rivas-Fernández Miguel Ángel Rivas-Fernández Mónica Lindín Mónica Lindín Montserrat Zurrón Montserrat Zurrón Fernando Díaz Fernando Díaz Cristina Lojo-Seoane Cristina Lojo-Seoane Arturo X. Pereiro Arturo X. Pereiro Santiago Galdo-Álvarez Santiago Galdo-Álvarez Neuroanatomical and neurocognitive changes associated with subjective cognitive decline Frontiers in Medicine Alzheimer’s disease subjective cognitive decline (SCD) structural magnetic resonance imaging brain structural changes subjective cognitive complaints |
| title | Neuroanatomical and neurocognitive changes associated with subjective cognitive decline |
| title_full | Neuroanatomical and neurocognitive changes associated with subjective cognitive decline |
| title_fullStr | Neuroanatomical and neurocognitive changes associated with subjective cognitive decline |
| title_full_unstemmed | Neuroanatomical and neurocognitive changes associated with subjective cognitive decline |
| title_short | Neuroanatomical and neurocognitive changes associated with subjective cognitive decline |
| title_sort | neuroanatomical and neurocognitive changes associated with subjective cognitive decline |
| topic | Alzheimer’s disease subjective cognitive decline (SCD) structural magnetic resonance imaging brain structural changes subjective cognitive complaints |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1094799/full |
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