Secondary cancers after carbon‐ion radiotherapy and photon beam radiotherapy for uterine cervical cancer: A comparative study
Abstract Background There are limited studies on the risk of secondary cancers after carbon‐ion radiotherapy (CIRT). We assessed the incidence of secondary cancers in patients treated with CIRT for cervical cancer. We also evaluated the incidence of secondary cancers in patients who received standar...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.4622 |
| _version_ | 1818469676755189760 |
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| author | Yuki Nitta Hiroto Murata Noriyuki Okonogi Kazutoshi Murata Masaru Wakatsuki Kumiko Karasawa Shingo Kato Shigeru Yamada Takashi Nakano Hiroshi Tsuji |
| author_facet | Yuki Nitta Hiroto Murata Noriyuki Okonogi Kazutoshi Murata Masaru Wakatsuki Kumiko Karasawa Shingo Kato Shigeru Yamada Takashi Nakano Hiroshi Tsuji |
| author_sort | Yuki Nitta |
| collection | DOAJ |
| description | Abstract Background There are limited studies on the risk of secondary cancers after carbon‐ion radiotherapy (CIRT). We assessed the incidence of secondary cancers in patients treated with CIRT for cervical cancer. We also evaluated the incidence of secondary cancers in patients who received standard photon radiotherapy (RT) throughout the same period. Methods This retrospective study included patients with cervical cancer who underwent curative RT at our hospital. All cancers discovered for the first time after RT were classified as secondary cancers. To compare the risk of secondary cancers among cervical cancer survivors to the general population, standardized incidence ratios (SIRs) were calculated. Results The analysis included a total of 197 and 417 patients in the CIRT and photon RT groups, respectively. The total person‐years during the observation period were 1052.4 in the CIRT group and 2481.5 in the photon RT group. The SIR for all secondary cancers was 1.1 (95% confidence interval [CI], 0.6–2.1) in the CIRT group and 1.4 (95% CI, 1.0–2.1) in the photon RT group. The 10‐year cumulative incidence of all secondary cancers was 9.5% (95% CI, 4.0–21.5) in the CIRT group and 9.4% (95% CI, 6.2–14.1) in the photon RT group. The CIRT and photon RT groups were not significantly different in incidence (p = 0.268). Conclusions The incidence of secondary cancers after CIRT for cervical cancer was similar to that after photon RT. Validation of our findings after long‐term observation is warranted. |
| first_indexed | 2024-04-13T21:26:49Z |
| format | Article |
| id | doaj.art-4400de774f2e41bda1f927ec0e99e9ca |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-13T21:26:49Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-4400de774f2e41bda1f927ec0e99e9ca2022-12-22T02:29:17ZengWileyCancer Medicine2045-76342022-06-0111122445245410.1002/cam4.4622Secondary cancers after carbon‐ion radiotherapy and photon beam radiotherapy for uterine cervical cancer: A comparative studyYuki Nitta0Hiroto Murata1Noriyuki Okonogi2Kazutoshi Murata3Masaru Wakatsuki4Kumiko Karasawa5Shingo Kato6Shigeru Yamada7Takashi Nakano8Hiroshi Tsuji9QST Hospital, National Institutes for Quantum Science and Technology Chiba JapanQST Hospital, National Institutes for Quantum Science and Technology Chiba JapanQST Hospital, National Institutes for Quantum Science and Technology Chiba JapanQST Hospital, National Institutes for Quantum Science and Technology Chiba JapanQST Hospital, National Institutes for Quantum Science and Technology Chiba JapanDepartment of Radiation Oncology Tokyo Women's Medical University School of Medicine Tokyo JapanDepartment of Radiation Oncology Saitama Medical University International Medical Center Hidaka JapanQST Hospital, National Institutes for Quantum Science and Technology Chiba JapanQuantum Medical Science Directorate National Institutes for Quantum Science and Technology Chiba JapanQST Hospital, National Institutes for Quantum Science and Technology Chiba JapanAbstract Background There are limited studies on the risk of secondary cancers after carbon‐ion radiotherapy (CIRT). We assessed the incidence of secondary cancers in patients treated with CIRT for cervical cancer. We also evaluated the incidence of secondary cancers in patients who received standard photon radiotherapy (RT) throughout the same period. Methods This retrospective study included patients with cervical cancer who underwent curative RT at our hospital. All cancers discovered for the first time after RT were classified as secondary cancers. To compare the risk of secondary cancers among cervical cancer survivors to the general population, standardized incidence ratios (SIRs) were calculated. Results The analysis included a total of 197 and 417 patients in the CIRT and photon RT groups, respectively. The total person‐years during the observation period were 1052.4 in the CIRT group and 2481.5 in the photon RT group. The SIR for all secondary cancers was 1.1 (95% confidence interval [CI], 0.6–2.1) in the CIRT group and 1.4 (95% CI, 1.0–2.1) in the photon RT group. The 10‐year cumulative incidence of all secondary cancers was 9.5% (95% CI, 4.0–21.5) in the CIRT group and 9.4% (95% CI, 6.2–14.1) in the photon RT group. The CIRT and photon RT groups were not significantly different in incidence (p = 0.268). Conclusions The incidence of secondary cancers after CIRT for cervical cancer was similar to that after photon RT. Validation of our findings after long‐term observation is warranted.https://doi.org/10.1002/cam4.4622carbon‐ion radiotherapychemoradiotherapyneoplasmsradiation oncologysecond primaryuterine cervical neoplasms |
| spellingShingle | Yuki Nitta Hiroto Murata Noriyuki Okonogi Kazutoshi Murata Masaru Wakatsuki Kumiko Karasawa Shingo Kato Shigeru Yamada Takashi Nakano Hiroshi Tsuji Secondary cancers after carbon‐ion radiotherapy and photon beam radiotherapy for uterine cervical cancer: A comparative study Cancer Medicine carbon‐ion radiotherapy chemoradiotherapy neoplasms radiation oncology second primary uterine cervical neoplasms |
| title | Secondary cancers after carbon‐ion radiotherapy and photon beam radiotherapy for uterine cervical cancer: A comparative study |
| title_full | Secondary cancers after carbon‐ion radiotherapy and photon beam radiotherapy for uterine cervical cancer: A comparative study |
| title_fullStr | Secondary cancers after carbon‐ion radiotherapy and photon beam radiotherapy for uterine cervical cancer: A comparative study |
| title_full_unstemmed | Secondary cancers after carbon‐ion radiotherapy and photon beam radiotherapy for uterine cervical cancer: A comparative study |
| title_short | Secondary cancers after carbon‐ion radiotherapy and photon beam radiotherapy for uterine cervical cancer: A comparative study |
| title_sort | secondary cancers after carbon ion radiotherapy and photon beam radiotherapy for uterine cervical cancer a comparative study |
| topic | carbon‐ion radiotherapy chemoradiotherapy neoplasms radiation oncology second primary uterine cervical neoplasms |
| url | https://doi.org/10.1002/cam4.4622 |
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