Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer’s disease
IntroductionAerobic exercise has been shown to modify Alzheimer pathology in animal models, and in patients with multiple sclerosis to reduce neurofilament light (NfL), a biomarker of neurodegeneration.ObjectiveTo investigate whether a 16-week aerobic exercise program was able to reduce serum NfL in...
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1108191/full |
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| author | Kristian Steen Frederiksen Camilla Steen Jensen Peter Høgh Peter Høgh Robert Gergelyffy Gunhild Waldemar Gunhild Waldemar Birgitte Bo Andersen Hanne Gottrup Karsten Vestergaard Lene Wermuth Lene Wermuth Helle Bach Søndergaard Finn Sellebjerg Steen Gregers Hasselbalch Steen Gregers Hasselbalch Anja Hviid Simonsen |
| author_facet | Kristian Steen Frederiksen Camilla Steen Jensen Peter Høgh Peter Høgh Robert Gergelyffy Gunhild Waldemar Gunhild Waldemar Birgitte Bo Andersen Hanne Gottrup Karsten Vestergaard Lene Wermuth Lene Wermuth Helle Bach Søndergaard Finn Sellebjerg Steen Gregers Hasselbalch Steen Gregers Hasselbalch Anja Hviid Simonsen |
| author_sort | Kristian Steen Frederiksen |
| collection | DOAJ |
| description | IntroductionAerobic exercise has been shown to modify Alzheimer pathology in animal models, and in patients with multiple sclerosis to reduce neurofilament light (NfL), a biomarker of neurodegeneration.ObjectiveTo investigate whether a 16-week aerobic exercise program was able to reduce serum NfL in patients with mild Alzheimer’s disease (AD).MethodsThis is a secondary analysis of data from the multi-center Preserving Cognition, Quality of Life, Physical Health, and Functional Ability in Alzheimer’s disease: The Effect of Physical Exercise (ADEX) study. Participants were randomized to 16 weeks of moderate intensity aerobic exercise or usual care. Clinical assessment and measurement of serum NfL was done at baseline and after the intervention.ResultsA total of 136 participants were included in the analysis. Groups were comparable at baseline except for APOEε4 carriership which was higher in the usual care group (75.3 versus 60.2%; p = 0.04). There was no effect of the intervention on serum NfL [intervention: baseline NfL (pg/mL) 25.76, change from baseline 0.87; usual care: baseline 27.09, change from baseline −1.16, p = 0.09].ConclusionThe findings do not support an effect of the exercise intervention on a single measure of neurodegeneration in AD. Further studies are needed using other types and durations of exercise and other measures of neurodegeneration.Clinical trial registrationclinicaltrials.gov, identifier NCT01681602. |
| first_indexed | 2024-04-10T20:47:50Z |
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| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-10T20:47:50Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-4400f001c5694e46bc8f0e4ee4a1f6ef2023-01-24T05:06:05ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-01-011710.3389/fnins.2023.11081911108191Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer’s diseaseKristian Steen Frederiksen0Camilla Steen Jensen1Peter Høgh2Peter Høgh3Robert Gergelyffy4Gunhild Waldemar5Gunhild Waldemar6Birgitte Bo Andersen7Hanne Gottrup8Karsten Vestergaard9Lene Wermuth10Lene Wermuth11Helle Bach Søndergaard12Finn Sellebjerg13Steen Gregers Hasselbalch14Steen Gregers Hasselbalch15Anja Hviid Simonsen16Department of Neurology, Danish Dementia Research Center, Copenhagen University Hospital–Rigshospitalet, Copenhagen, DenmarkDepartment of Neurology, Danish Dementia Research Center, Copenhagen University Hospital–Rigshospitalet, Copenhagen, DenmarkDepartment of Neurology, Regional Dementia Research Centre, Zealand University Hospital, University of Copenhagen, Copenhagen, DenmarkDepartment of Clinical Medicine, Regional Dementia Research Centre, Zealand University Hospital, University of Copenhagen, Copenhagen, DenmarkDepartment of Geriatrics, Slagelse Hospital, Slagelse, DenmarkDepartment of Neurology, Danish Dementia Research Center, Copenhagen University Hospital–Rigshospitalet, Copenhagen, DenmarkDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Neurology, Danish Dementia Research Center, Copenhagen University Hospital–Rigshospitalet, Copenhagen, DenmarkDementia Clinic, Aarhus University Hospital, Aarhus, DenmarkDementia Clinic, Aalborg University Hospital, Aalborg, DenmarkDepartment of Neurology, Dementia Clinic, Slagelse Hospital, Slagelse, DenmarkDepartment of Regional Health Research, University of Southern Denmark, Odense, Denmark0Danish Multiple Sclerosis Center, Copenhagen University Hospital–Rigshospitalet, Glostrup, Denmark0Danish Multiple Sclerosis Center, Copenhagen University Hospital–Rigshospitalet, Glostrup, DenmarkDepartment of Neurology, Danish Dementia Research Center, Copenhagen University Hospital–Rigshospitalet, Copenhagen, DenmarkDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Neurology, Danish Dementia Research Center, Copenhagen University Hospital–Rigshospitalet, Copenhagen, DenmarkIntroductionAerobic exercise has been shown to modify Alzheimer pathology in animal models, and in patients with multiple sclerosis to reduce neurofilament light (NfL), a biomarker of neurodegeneration.ObjectiveTo investigate whether a 16-week aerobic exercise program was able to reduce serum NfL in patients with mild Alzheimer’s disease (AD).MethodsThis is a secondary analysis of data from the multi-center Preserving Cognition, Quality of Life, Physical Health, and Functional Ability in Alzheimer’s disease: The Effect of Physical Exercise (ADEX) study. Participants were randomized to 16 weeks of moderate intensity aerobic exercise or usual care. Clinical assessment and measurement of serum NfL was done at baseline and after the intervention.ResultsA total of 136 participants were included in the analysis. Groups were comparable at baseline except for APOEε4 carriership which was higher in the usual care group (75.3 versus 60.2%; p = 0.04). There was no effect of the intervention on serum NfL [intervention: baseline NfL (pg/mL) 25.76, change from baseline 0.87; usual care: baseline 27.09, change from baseline −1.16, p = 0.09].ConclusionThe findings do not support an effect of the exercise intervention on a single measure of neurodegeneration in AD. Further studies are needed using other types and durations of exercise and other measures of neurodegeneration.Clinical trial registrationclinicaltrials.gov, identifier NCT01681602.https://www.frontiersin.org/articles/10.3389/fnins.2023.1108191/fullexerciseAlzheimer’s diseasedementiainterventionneurofilament lightneurodegeneration |
| spellingShingle | Kristian Steen Frederiksen Camilla Steen Jensen Peter Høgh Peter Høgh Robert Gergelyffy Gunhild Waldemar Gunhild Waldemar Birgitte Bo Andersen Hanne Gottrup Karsten Vestergaard Lene Wermuth Lene Wermuth Helle Bach Søndergaard Finn Sellebjerg Steen Gregers Hasselbalch Steen Gregers Hasselbalch Anja Hviid Simonsen Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer’s disease Frontiers in Neuroscience exercise Alzheimer’s disease dementia intervention neurofilament light neurodegeneration |
| title | Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer’s disease |
| title_full | Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer’s disease |
| title_fullStr | Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer’s disease |
| title_full_unstemmed | Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer’s disease |
| title_short | Aerobic exercise does not affect serum neurofilament light in patients with mild Alzheimer’s disease |
| title_sort | aerobic exercise does not affect serum neurofilament light in patients with mild alzheimer s disease |
| topic | exercise Alzheimer’s disease dementia intervention neurofilament light neurodegeneration |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1108191/full |
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