Fecal calprotectin: a marker for clinical differentiation of microscopic colitis and irritable bowel syndrome
Ulrike von Arnim, Thomas Wex, Christine Ganzert, Christian Schulz, Peter Malfertheiner Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany Background: The aim of this study is to compare two methods for measuring fecal calpro...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-04-01
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| Series: | Clinical and Experimental Gastroenterology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/fecal-calprotectin-a-marker-for-clinical-differentiation-of-microscopi-peer-reviewed-article-CEG |
| _version_ | 1818345134614380544 |
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| author | von Arnim U Wex T Ganzert C Schulz C Malfertheiner P |
| author_facet | von Arnim U Wex T Ganzert C Schulz C Malfertheiner P |
| author_sort | von Arnim U |
| collection | DOAJ |
| description | Ulrike von Arnim, Thomas Wex, Christine Ganzert, Christian Schulz, Peter Malfertheiner Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany Background: The aim of this study is to compare two methods for measuring fecal calprotectin (FC) concentration and to evaluate the possibility of differentiation between microscopic colitis (MC) and irritable bowel syndrome (IBS). Methods: Twenty-three patients with MC (six patients with active disease and 17 patients retested in remission) and 20 patients with IBS were prospectively included in this study. Active disease state of MC was determined by clinical symptoms of >3 bowel movements per day and histological correlate. All patients underwent ileocolonoscopy, including segmental biopsy samples for histology. FC levels in stool samples were analyzed using a rapid test system (Quantum Blue®) and an enzyme-linked immunosorbent assay (ELISA). Results: FC levels were significantly higher in patients with active MC (median 48 µg/g [23–106]) compared to patients with IBS (median 2 µg/g [1–111.83]), P=0.0001 using an ELISA. FC level of patients with MC in remission was 22 µg/g (1–106.4), which is similar to those identified in patients with IBS. The difference of FC levels between active MC and IBS was not detected by the FC rapid test (P=0.635). Discussion: FC levels might serve as parameter for differentiation between patients with active MC and IBS. Since there is no surrogate marker available at present for MC, FC appears to be a candidate for differentiating MC from IBS. Conclusion: High FC levels, which were analyzed by ELISA, are a potential marker for patients with active MC compared to those with IBS. The FC rapid test was less suitable for this purpose. Keywords: microscopic colitis, fecal calprotectin, irritable bowel syndrome, IBS, diarrhea, chronic diarrhea |
| first_indexed | 2024-12-13T16:57:33Z |
| format | Article |
| id | doaj.art-44014eedf1ab41399c32a0ca8c5fdfdc |
| institution | Directory Open Access Journal |
| issn | 1178-7023 |
| language | English |
| last_indexed | 2024-12-13T16:57:33Z |
| publishDate | 2016-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical and Experimental Gastroenterology |
| spelling | doaj.art-44014eedf1ab41399c32a0ca8c5fdfdc2022-12-21T23:37:53ZengDove Medical PressClinical and Experimental Gastroenterology1178-70232016-04-012016Issue 19710326564Fecal calprotectin: a marker for clinical differentiation of microscopic colitis and irritable bowel syndromevon Arnim UWex TGanzert CSchulz CMalfertheiner PUlrike von Arnim, Thomas Wex, Christine Ganzert, Christian Schulz, Peter Malfertheiner Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany Background: The aim of this study is to compare two methods for measuring fecal calprotectin (FC) concentration and to evaluate the possibility of differentiation between microscopic colitis (MC) and irritable bowel syndrome (IBS). Methods: Twenty-three patients with MC (six patients with active disease and 17 patients retested in remission) and 20 patients with IBS were prospectively included in this study. Active disease state of MC was determined by clinical symptoms of >3 bowel movements per day and histological correlate. All patients underwent ileocolonoscopy, including segmental biopsy samples for histology. FC levels in stool samples were analyzed using a rapid test system (Quantum Blue®) and an enzyme-linked immunosorbent assay (ELISA). Results: FC levels were significantly higher in patients with active MC (median 48 µg/g [23–106]) compared to patients with IBS (median 2 µg/g [1–111.83]), P=0.0001 using an ELISA. FC level of patients with MC in remission was 22 µg/g (1–106.4), which is similar to those identified in patients with IBS. The difference of FC levels between active MC and IBS was not detected by the FC rapid test (P=0.635). Discussion: FC levels might serve as parameter for differentiation between patients with active MC and IBS. Since there is no surrogate marker available at present for MC, FC appears to be a candidate for differentiating MC from IBS. Conclusion: High FC levels, which were analyzed by ELISA, are a potential marker for patients with active MC compared to those with IBS. The FC rapid test was less suitable for this purpose. Keywords: microscopic colitis, fecal calprotectin, irritable bowel syndrome, IBS, diarrhea, chronic diarrheahttps://www.dovepress.com/fecal-calprotectin-a-marker-for-clinical-differentiation-of-microscopi-peer-reviewed-article-CEGmicroscopic colitisfecal calprotectinirritable bowel syndrome |
| spellingShingle | von Arnim U Wex T Ganzert C Schulz C Malfertheiner P Fecal calprotectin: a marker for clinical differentiation of microscopic colitis and irritable bowel syndrome Clinical and Experimental Gastroenterology microscopic colitis fecal calprotectin irritable bowel syndrome |
| title | Fecal calprotectin: a marker for clinical differentiation of microscopic colitis and irritable bowel syndrome |
| title_full | Fecal calprotectin: a marker for clinical differentiation of microscopic colitis and irritable bowel syndrome |
| title_fullStr | Fecal calprotectin: a marker for clinical differentiation of microscopic colitis and irritable bowel syndrome |
| title_full_unstemmed | Fecal calprotectin: a marker for clinical differentiation of microscopic colitis and irritable bowel syndrome |
| title_short | Fecal calprotectin: a marker for clinical differentiation of microscopic colitis and irritable bowel syndrome |
| title_sort | fecal calprotectin a marker for clinical differentiation of microscopic colitis and irritable bowel syndrome |
| topic | microscopic colitis fecal calprotectin irritable bowel syndrome |
| url | https://www.dovepress.com/fecal-calprotectin-a-marker-for-clinical-differentiation-of-microscopi-peer-reviewed-article-CEG |
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