The Diverse Roles of TNNI3K in Cardiac Disease and Potential for Treatment
In the two decades since the discovery of TNNI3K it has been implicated in multiple cardiac phenotypes and physiological processes. TNNI3K is an understudied kinase, which is mainly expressed in the heart. Human genetic variants in <i>TNNI3K</i> are associated with supraventricular arrhy...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/12/6422 |
| _version_ | 1797530043380924416 |
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| author | Caroline Pham Noelia Muñoz-Martín Elisabeth M. Lodder |
| author_facet | Caroline Pham Noelia Muñoz-Martín Elisabeth M. Lodder |
| author_sort | Caroline Pham |
| collection | DOAJ |
| description | In the two decades since the discovery of TNNI3K it has been implicated in multiple cardiac phenotypes and physiological processes. TNNI3K is an understudied kinase, which is mainly expressed in the heart. Human genetic variants in <i>TNNI3K</i> are associated with supraventricular arrhythmias, conduction disease, and cardiomyopathy. Furthermore, studies in mice implicate the gene in cardiac hypertrophy, cardiac regeneration, and recovery after ischemia/reperfusion injury. Several new papers on TNNI3K have been published since the last overview, broadening the clinical perspective of <i>TNNI3K</i> variants and our understanding of the underlying molecular biology. We here provide an overview of the role of TNNI3K in cardiomyopathy and arrhythmia covering both a clinical perspective and basic science advancements. In addition, we review the potential of TNNI3K as a target for clinical treatments in different cardiac diseases. |
| first_indexed | 2024-03-10T10:22:18Z |
| format | Article |
| id | doaj.art-44036d14c4bd431188babc2b7e98aac0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:22:18Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-44036d14c4bd431188babc2b7e98aac02023-11-22T00:15:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012212642210.3390/ijms22126422The Diverse Roles of TNNI3K in Cardiac Disease and Potential for TreatmentCaroline Pham0Noelia Muñoz-Martín1Elisabeth M. Lodder2Department of Clinical and Experimental Cardiology, Heart Center, University of Amsterdam, Amsterdam UMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Clinical and Experimental Cardiology, Heart Center, University of Amsterdam, Amsterdam UMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Clinical and Experimental Cardiology, Heart Center, University of Amsterdam, Amsterdam UMC, 1105 AZ Amsterdam, The NetherlandsIn the two decades since the discovery of TNNI3K it has been implicated in multiple cardiac phenotypes and physiological processes. TNNI3K is an understudied kinase, which is mainly expressed in the heart. Human genetic variants in <i>TNNI3K</i> are associated with supraventricular arrhythmias, conduction disease, and cardiomyopathy. Furthermore, studies in mice implicate the gene in cardiac hypertrophy, cardiac regeneration, and recovery after ischemia/reperfusion injury. Several new papers on TNNI3K have been published since the last overview, broadening the clinical perspective of <i>TNNI3K</i> variants and our understanding of the underlying molecular biology. We here provide an overview of the role of TNNI3K in cardiomyopathy and arrhythmia covering both a clinical perspective and basic science advancements. In addition, we review the potential of TNNI3K as a target for clinical treatments in different cardiac diseases.https://www.mdpi.com/1422-0067/22/12/6422TNNI3Ksupraventricular arrhythmiascardiomyopathycardiac regenerationconduction diseasehypertrophy |
| spellingShingle | Caroline Pham Noelia Muñoz-Martín Elisabeth M. Lodder The Diverse Roles of TNNI3K in Cardiac Disease and Potential for Treatment International Journal of Molecular Sciences TNNI3K supraventricular arrhythmias cardiomyopathy cardiac regeneration conduction disease hypertrophy |
| title | The Diverse Roles of TNNI3K in Cardiac Disease and Potential for Treatment |
| title_full | The Diverse Roles of TNNI3K in Cardiac Disease and Potential for Treatment |
| title_fullStr | The Diverse Roles of TNNI3K in Cardiac Disease and Potential for Treatment |
| title_full_unstemmed | The Diverse Roles of TNNI3K in Cardiac Disease and Potential for Treatment |
| title_short | The Diverse Roles of TNNI3K in Cardiac Disease and Potential for Treatment |
| title_sort | diverse roles of tnni3k in cardiac disease and potential for treatment |
| topic | TNNI3K supraventricular arrhythmias cardiomyopathy cardiac regeneration conduction disease hypertrophy |
| url | https://www.mdpi.com/1422-0067/22/12/6422 |
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