Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality

Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality

Single domain antibodies (sdAbs) have proven to be valuable probes for molecular imaging. In order to produce such probes, one strategy is the functionalization of the reactive amine side chain of lysines with a chelator, resulting in a mixture of compounds with a different degree of conjugation. In...

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Bibliographic Details
Main Authors: Henri Baudhuin, Janik Puttemans, Heleen Hanssens, Philippe Vanwolleghem, Sophie Hernot, Geert Raes, Catarina Xavier, Tony Lahoutte, Pieterjan Debie
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceuticals
Subjects:
bioconjugation
ion exchange chromatography
molecular imaging
radiopharmaceutical
tracer optimization
kidney clearance
Online Access:https://www.mdpi.com/1424-8247/14/5/407

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