Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity

Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity

A key feature of advanced brain aging includes structural defects of intracortical myelin that are associated with secondary neuroinflammation. A similar pathology is seen in specific myelin mutant mice that model ‘advanced brain aging’ and exhibit a range of behavioral abnormalities. However, the c...

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Bibliographic Details
Main Authors: Sahab Arinrad, Constanze Depp, Sophie B Siems, Andrew Octavian Sasmita, Maria A Eichel, Anja Ronnenberg, Kurt Hammerschmidt, Katja A Lüders, Hauke B Werner, Hannelore Ehrenreich, Klaus-Armin Nave
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
myelin
mouse mutant
oligodendrocytes
glia function
disease model
executive functions
Online Access:https://elifesciences.org/articles/70792

Internet

https://elifesciences.org/articles/70792

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