Serum Concentrations of Antigen-Specific IgG4 in Patients with Japanese Cedar Pollinosis
Purpose: To elucidate the usefulness of Japanese cedar pollen (JCP)-specific antigen-specific immunoglobulin (IgG) 4 as a biomarker for predicting the efficacy of sublingual immunotherapy for cedar pollen-induced allergic rhinitis. Methods: We divided a total of 105 cases with Japanese cedar pollino...
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MDPI AG
2021-07-01
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| Series: | Allergies |
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| Online Access: | https://www.mdpi.com/2313-5786/1/3/13 |
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| author | Shiori Kitaya Nobuo Ohta Atsushi Yuta Yukiko Ogawa Yusuke Suzuki Seiya Ichihara Ryoukichi Ikeda Tadao Enomoto Hideaki Kouzaki Takeshi Shimizu Junya Ono Kenji Izuhara Yoshitaka Okamoto |
| author_facet | Shiori Kitaya Nobuo Ohta Atsushi Yuta Yukiko Ogawa Yusuke Suzuki Seiya Ichihara Ryoukichi Ikeda Tadao Enomoto Hideaki Kouzaki Takeshi Shimizu Junya Ono Kenji Izuhara Yoshitaka Okamoto |
| author_sort | Shiori Kitaya |
| collection | DOAJ |
| description | Purpose: To elucidate the usefulness of Japanese cedar pollen (JCP)-specific antigen-specific immunoglobulin (IgG) 4 as a biomarker for predicting the efficacy of sublingual immunotherapy for cedar pollen-induced allergic rhinitis. Methods: We divided a total of 105 cases with Japanese cedar pollinosis into three groups: “SLIT Successful,” SLIT Unsatisfactory,” and “SCIT” groups. The SLIT group patients were treated with JCP Droplet (Torii Pharmaceutical Co. Ltd., Tokyo, Japan) for one year from 2015 and were divided into two groups, the SLIT Successful group or the SLIT Unsatisfactory group. The SLIT Successful group (<i>n</i> = 16) were subjects treated by SLIT only, who were able to experience control of their naso-ocular symptoms without the need for antiallergic rescue agents during the peak season of atmospheric pollen. The SLIT Unsatisfactory group (<i>n</i> = 76) comprised subjects treated with SLIT only, who did not respond successfully, and were administered with rescue agents to control their naso-ocular symptoms. The SCIT group had been treated with standardized JCP extract (Torii Pharmaceutical Co., Ltd., Tokyo, Japan) for three years from 2012, and were also able to experience control of their symptoms during the peak pollen season without the need for antiallergic rescue agents. We determined the serum level of JCP-specific immunoglobulin E (IgE), IgG, and IgG4 used in the 3gAllergy-specific IgE assay (3gAllergy). The serum levels of periostin and SCCA2 were measured using established ELISA procedures (clones SS18A and SS17B; Shino-Test, Japan) following the manufacturer’s instructions. We then made ROC curves for each group and assessed which index was best able to predict the efficacy of sublingual immunotherapy. Results: Serum JCP-specific IgE was significantly lower in the SCIT group than in the SLIT Successful group and the SLIT Unsatisfactory group (<i>p</i> < 0.05). Serum JCP-specific IgG was significantly higher in the SCIT group and the SLIT Successful group than in the SLIT Unsatisfactory group (<i>p</i> < 0.05). Serum JCP-specific IgG4 was also significantly higher in the SCIT group and the SLIT Successful group than in the SLIT Unsatisfactory group (<i>p</i> < 0.05). There was no significant difference among serum levels of periostin in the SCIT group, the SLIT Successful group, or the SLIT Unsatisfactory group. There was also no significant difference in SCCA2 among the three groups. In terms of ROC curves, a serum JCP-specific IgG4 value greater than 989.5 UA/mL showed the best sensitivity (93.3%) and specificity (94.7%) (<i>p</i> < 0.05) among other parameters. Conclusions: The serum JCP-specific IgG4 level is significantly correlated with the clinical efficacy of SLIT. Serum JCP-specific IgG4 cutoff levels greater than 989.5 UA/mL were correlated with an effective clinical response to SLIT, with a sensitivity of 93.3% and a specificity of 94.7%. |
| first_indexed | 2024-03-10T07:57:56Z |
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| institution | Directory Open Access Journal |
| issn | 2313-5786 |
| language | English |
| last_indexed | 2024-03-10T07:57:56Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Allergies |
| spelling | doaj.art-440721c4e09544e99bf5143c9b93518e2023-11-22T11:40:33ZengMDPI AGAllergies2313-57862021-07-011314014910.3390/allergies1030013Serum Concentrations of Antigen-Specific IgG4 in Patients with Japanese Cedar PollinosisShiori Kitaya0Nobuo Ohta1Atsushi Yuta2Yukiko Ogawa3Yusuke Suzuki4Seiya Ichihara5Ryoukichi Ikeda6Tadao Enomoto7Hideaki Kouzaki8Takeshi Shimizu9Junya Ono10Kenji Izuhara11Yoshitaka Okamoto12Department of Otolaryngology, Head and Neck Surgery, Tohoku University Hospital 1-1, Seiryomachi, Aoba-ku, Sendai 980-8574, JapanDivision of Otolaryngology, Tohoku Medical and Pharmaceutical University Hospital 1-12-1, Fukumuro, Miyagino-ku, Sendai 983-8512, JapanYuta Clinic, 2-3 Syuseicho, Tsu 514-0837, JapanYuta Clinic, 2-3 Syuseicho, Tsu 514-0837, JapanDepartment of Otolaryngology, Head and Neck Surgery, Yamagata University Faculty of Medicine, 2-2-2 Iidanishi, Yamagata 990-9585, JapanDivision of Otolaryngology, Tohoku Medical and Pharmaceutical University Hospital 1-12-1, Fukumuro, Miyagino-ku, Sendai 983-8512, JapanDepartment of Otolaryngology, Head and Neck Surgery, Tohoku University Hospital 1-1, Seiryomachi, Aoba-ku, Sendai 980-8574, JapanDepartment of Otolaryngology, Head and Neck Surgery, Tottori University Faculty of Medicine, 86 Nishimachi, Yonago 683-8503, JapanDepartment of Otolaryngology, Head and Neck Surgery, Shiga University of Medical Science, Setatsukinowacho, Otsu 520-2192, JapanDepartment of Otolaryngology, Head and Neck Surgery, Shiga University of Medical Science, Setatsukinowacho, Otsu 520-2192, JapanShino-Test Corporation, 2-29-14 Onodai Minami-ku, Sagamihara 252-0331, JapanDivision of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, JapanDepartment of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanPurpose: To elucidate the usefulness of Japanese cedar pollen (JCP)-specific antigen-specific immunoglobulin (IgG) 4 as a biomarker for predicting the efficacy of sublingual immunotherapy for cedar pollen-induced allergic rhinitis. Methods: We divided a total of 105 cases with Japanese cedar pollinosis into three groups: “SLIT Successful,” SLIT Unsatisfactory,” and “SCIT” groups. The SLIT group patients were treated with JCP Droplet (Torii Pharmaceutical Co. Ltd., Tokyo, Japan) for one year from 2015 and were divided into two groups, the SLIT Successful group or the SLIT Unsatisfactory group. The SLIT Successful group (<i>n</i> = 16) were subjects treated by SLIT only, who were able to experience control of their naso-ocular symptoms without the need for antiallergic rescue agents during the peak season of atmospheric pollen. The SLIT Unsatisfactory group (<i>n</i> = 76) comprised subjects treated with SLIT only, who did not respond successfully, and were administered with rescue agents to control their naso-ocular symptoms. The SCIT group had been treated with standardized JCP extract (Torii Pharmaceutical Co., Ltd., Tokyo, Japan) for three years from 2012, and were also able to experience control of their symptoms during the peak pollen season without the need for antiallergic rescue agents. We determined the serum level of JCP-specific immunoglobulin E (IgE), IgG, and IgG4 used in the 3gAllergy-specific IgE assay (3gAllergy). The serum levels of periostin and SCCA2 were measured using established ELISA procedures (clones SS18A and SS17B; Shino-Test, Japan) following the manufacturer’s instructions. We then made ROC curves for each group and assessed which index was best able to predict the efficacy of sublingual immunotherapy. Results: Serum JCP-specific IgE was significantly lower in the SCIT group than in the SLIT Successful group and the SLIT Unsatisfactory group (<i>p</i> < 0.05). Serum JCP-specific IgG was significantly higher in the SCIT group and the SLIT Successful group than in the SLIT Unsatisfactory group (<i>p</i> < 0.05). Serum JCP-specific IgG4 was also significantly higher in the SCIT group and the SLIT Successful group than in the SLIT Unsatisfactory group (<i>p</i> < 0.05). There was no significant difference among serum levels of periostin in the SCIT group, the SLIT Successful group, or the SLIT Unsatisfactory group. There was also no significant difference in SCCA2 among the three groups. In terms of ROC curves, a serum JCP-specific IgG4 value greater than 989.5 UA/mL showed the best sensitivity (93.3%) and specificity (94.7%) (<i>p</i> < 0.05) among other parameters. Conclusions: The serum JCP-specific IgG4 level is significantly correlated with the clinical efficacy of SLIT. Serum JCP-specific IgG4 cutoff levels greater than 989.5 UA/mL were correlated with an effective clinical response to SLIT, with a sensitivity of 93.3% and a specificity of 94.7%.https://www.mdpi.com/2313-5786/1/3/13sublingual immunotherapyJapanese cedar pollinosisIgG4subcutaneous immunotherapyperiostin |
| spellingShingle | Shiori Kitaya Nobuo Ohta Atsushi Yuta Yukiko Ogawa Yusuke Suzuki Seiya Ichihara Ryoukichi Ikeda Tadao Enomoto Hideaki Kouzaki Takeshi Shimizu Junya Ono Kenji Izuhara Yoshitaka Okamoto Serum Concentrations of Antigen-Specific IgG4 in Patients with Japanese Cedar Pollinosis Allergies sublingual immunotherapy Japanese cedar pollinosis IgG4 subcutaneous immunotherapy periostin |
| title | Serum Concentrations of Antigen-Specific IgG4 in Patients with Japanese Cedar Pollinosis |
| title_full | Serum Concentrations of Antigen-Specific IgG4 in Patients with Japanese Cedar Pollinosis |
| title_fullStr | Serum Concentrations of Antigen-Specific IgG4 in Patients with Japanese Cedar Pollinosis |
| title_full_unstemmed | Serum Concentrations of Antigen-Specific IgG4 in Patients with Japanese Cedar Pollinosis |
| title_short | Serum Concentrations of Antigen-Specific IgG4 in Patients with Japanese Cedar Pollinosis |
| title_sort | serum concentrations of antigen specific igg4 in patients with japanese cedar pollinosis |
| topic | sublingual immunotherapy Japanese cedar pollinosis IgG4 subcutaneous immunotherapy periostin |
| url | https://www.mdpi.com/2313-5786/1/3/13 |
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