olubility Enhancement for Dietheyldithiocarbamate-Zinc for Lung Cancer Treatment
Diethyldithiocarbamate zinc (Zn(DDC)2), has shown promising antineoplastic effects against a wide variety of cancers. However, this application was hindered by its poor water solubility. Therefore, complexation with cyclodextrin was used to enhance the solubility. Five different concentrations of 2-...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Huddersfield Press
2022-11-01
|
| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/id/1147/ |
| _version_ | 1797825306163150848 |
|---|---|
| author | Ayse Kaya Niusha Ansari-Fard Dan Alves Basel Arafat Havovi Chichger Mohammad Najlah |
| author_facet | Ayse Kaya Niusha Ansari-Fard Dan Alves Basel Arafat Havovi Chichger Mohammad Najlah |
| author_sort | Ayse Kaya |
| collection | DOAJ |
| description | Diethyldithiocarbamate zinc (Zn(DDC)2), has shown promising antineoplastic effects against a wide variety of cancers. However, this application was hindered by its poor water solubility. Therefore, complexation with cyclodextrin was used to enhance the solubility. Five different concentrations of 2-hydroxyl beta-cyclodextrin (HP) and ether beta-cyclodextrin (SBE) were used. CD-Zn(DDC)2 solutions were freez-dried for further characterisation using DSC, TGA and FT-IR. The phase solubility study showed a significant water-solubility enchantment of Zn(DDC)2, and the characterisation studies confirmed the formation of inclusion complexes CD-Zn(DDC)2. Overall, CDs have improved Zn(DDC)2 solubility significantly and showed a promising anticancer activity against lung cancer cells. Hence, CD-Zn(DDC)2 complexes have a great potential for further studies against cancer. |
| first_indexed | 2024-03-13T10:52:04Z |
| format | Article |
| id | doaj.art-44080c58d1964a19bf8db3285ab557d3 |
| institution | Directory Open Access Journal |
| issn | 2058-8356 |
| language | English |
| last_indexed | 2024-03-13T10:52:04Z |
| publishDate | 2022-11-01 |
| publisher | University of Huddersfield Press |
| record_format | Article |
| series | British Journal of Pharmacy |
| spelling | doaj.art-44080c58d1964a19bf8db3285ab557d32023-05-17T10:13:30ZengUniversity of Huddersfield PressBritish Journal of Pharmacy2058-83562022-11-017210.5920/bjpharm.1147olubility Enhancement for Dietheyldithiocarbamate-Zinc for Lung Cancer TreatmentAyse Kaya 0Niusha Ansari-Fard1Dan Alves2Basel Arafat 3Havovi Chichger4Mohammad Najlah5Anglia Ruskin UniversityAnglia Ruskin UniversityAnglia Ruskin UniversityAnglia Ruskin UniversityAnglia Ruskin UniversityAnglia Ruskin UniversityDiethyldithiocarbamate zinc (Zn(DDC)2), has shown promising antineoplastic effects against a wide variety of cancers. However, this application was hindered by its poor water solubility. Therefore, complexation with cyclodextrin was used to enhance the solubility. Five different concentrations of 2-hydroxyl beta-cyclodextrin (HP) and ether beta-cyclodextrin (SBE) were used. CD-Zn(DDC)2 solutions were freez-dried for further characterisation using DSC, TGA and FT-IR. The phase solubility study showed a significant water-solubility enchantment of Zn(DDC)2, and the characterisation studies confirmed the formation of inclusion complexes CD-Zn(DDC)2. Overall, CDs have improved Zn(DDC)2 solubility significantly and showed a promising anticancer activity against lung cancer cells. Hence, CD-Zn(DDC)2 complexes have a great potential for further studies against cancer. https://www.bjpharm.org.uk/article/id/1147/diethyldithiocarbamate-zinccyclodextrinssolubilityinclusion complexeslung cancer |
| spellingShingle | Ayse Kaya Niusha Ansari-Fard Dan Alves Basel Arafat Havovi Chichger Mohammad Najlah olubility Enhancement for Dietheyldithiocarbamate-Zinc for Lung Cancer Treatment British Journal of Pharmacy diethyldithiocarbamate-zinc cyclodextrins solubility inclusion complexes lung cancer |
| title | olubility Enhancement for Dietheyldithiocarbamate-Zinc for Lung Cancer Treatment |
| title_full | olubility Enhancement for Dietheyldithiocarbamate-Zinc for Lung Cancer Treatment |
| title_fullStr | olubility Enhancement for Dietheyldithiocarbamate-Zinc for Lung Cancer Treatment |
| title_full_unstemmed | olubility Enhancement for Dietheyldithiocarbamate-Zinc for Lung Cancer Treatment |
| title_short | olubility Enhancement for Dietheyldithiocarbamate-Zinc for Lung Cancer Treatment |
| title_sort | olubility enhancement for dietheyldithiocarbamate zinc for lung cancer treatment |
| topic | diethyldithiocarbamate-zinc cyclodextrins solubility inclusion complexes lung cancer |
| url | https://www.bjpharm.org.uk/article/id/1147/ |
| work_keys_str_mv | AT aysekaya olubilityenhancementfordietheyldithiocarbamatezincforlungcancertreatment AT niushaansarifard olubilityenhancementfordietheyldithiocarbamatezincforlungcancertreatment AT danalves olubilityenhancementfordietheyldithiocarbamatezincforlungcancertreatment AT baselarafat olubilityenhancementfordietheyldithiocarbamatezincforlungcancertreatment AT havovichichger olubilityenhancementfordietheyldithiocarbamatezincforlungcancertreatment AT mohammadnajlah olubilityenhancementfordietheyldithiocarbamatezincforlungcancertreatment |